Introduction to Epigenetics: Histone Modifications & DNA Methylation Quiz
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Questions and Answers

What are histone modifications?

  • Reversible chemical modifications to histone tails (correct)
  • Methylation of DNA
  • Changes in the nucleotide sequence
  • Phosphorylation of DNA
  • Which enzyme is responsible for adding acetyl groups to histones?

  • Histone methyltransferase (HMT)
  • Histone acetyltransferase (HAT) (correct)
  • Histone deacetylase (HDAC)
  • DNA Methyltransferase (DNMT)
  • What is the function of H3K27ac modification?

  • Associated with gene expression (correct)
  • Associated with repetitive sequences
  • Associated with gene silencing
  • Associated with DNA damage
  • What is the role of DNA methyltransferase (DNMT1)?

    <p>Maintain DNA methylation patterns</p> Signup and view all the answers

    What is the significance of CpG islands in promoters?

    <p>Prevent DNA methylation</p> Signup and view all the answers

    What is the main function of histone deacetylase (HDAC)?

    <p>To remove acetyl groups from histones, leading to gene repression</p> Signup and view all the answers

    What is the role of DNA methyltransferase (DNMT1) in the process of epigenetics?

    <p>It adds methyl groups to DNA, leading to gene repression</p> Signup and view all the answers

    What is the significance of H3K4me1 histone modification?

    <p>It is associated with gene expression and serves as an activating mark</p> Signup and view all the answers

    What are the main targets of DNA methylation in the genome?

    <p>CpG islands in promoters</p> Signup and view all the answers

    What is the main function of histone acetyltransferase (HAT) in epigenetics?

    <p>To add acetyl groups to histones, leading to gene activation</p> Signup and view all the answers

    Which of the following best describes epigenetics?

    <p>Heritable chemical modifications to the genome or its scaffold that do not involve changes in nucleotide sequence</p> Signup and view all the answers

    What is the function of histone acetyltransferase (HAT) in epigenetics?

    <p>Adding acetyl groups to histones</p> Signup and view all the answers

    Which modification signature serves as a code for newly replicated DNA, DNA damage, and gene silencing or expression?

    <p>H3K4me1</p> Signup and view all the answers

    What is the main role of DNA Methyltransferase (DNMT1) in epigenetics?

    <p>Maintaining DNA methylation patterns</p> Signup and view all the answers

    What are CpG islands primarily associated with in the genome?

    <p>Gene silencing</p> Signup and view all the answers

    Study Notes

    Histone Modifications

    • Histone modifications are epigenetic changes that alter chromatin structure and gene expression without altering the DNA sequence.

    Histone Acetylation

    • Histone acetyltransferase (HAT) is the enzyme responsible for adding acetyl groups to histones.
    • The main function of HAT in epigenetics is to relax chromatin structure, allowing for transcriptional activation.
    • H3K27ac modification is a mark of active gene expression and is associated with enhancers and promoters.

    DNA Methylation

    • DNA methyltransferase (DNMT1) is the enzyme responsible for adding methyl groups to CpG dinucleotides.
    • The main function of DNMT1 in epigenetics is to maintain DNA methylation patterns during DNA replication and repair.
    • CpG islands are primarily associated with gene promoters and are usually unmethylated, allowing for gene expression.
    • The main targets of DNA methylation in the genome are CpG-rich regions, including gene promoters and enhancers.

    Histone Deacetylation

    • Histone deacetylase (HDAC) is the enzyme responsible for removing acetyl groups from histones.
    • The main function of HDAC in epigenetics is to compact chromatin structure, leading to transcriptional repression.

    Epigenetic Significance

    • Epigenetics is the study of heritable changes in gene function that occur without a change in the DNA sequence.
    • The modification signature of histone modifications, including H3K4me1, serves as a code for newly replicated DNA, DNA damage, and gene silencing or expression.
    • H3K4me1 is a mark of active gene expression and is associated with enhancers and promoters.

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    Description

    Test your knowledge on epigenetics, histone modifications, and DNA methylation through this quiz. Explore concepts like chemical modifications to the genome, histone modifications, reversible modifications, and enzymes involved in the process.

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