Ephedrine HCl pKa and Proton Donating/Acceptor Properties Quiz

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What is one of the factors that play a crucial role in the biological activity of drugs?

3D shape of the molecule (correct)

Type of packaging used for the drug

Color of the drug

Country of origin of the drug

How is the fit of drugs onto macromolecules described in the text?

Continuous process (correct)

All-or-none process

Random process

Intermittent process

What can cause significant changes in biological activity?

Changing the brand name

Very slight changes in structure (correct)

Radical changes in color

Increasing the packaging size

What concept was used to explain why certain structural features produce predictable pharmacological actions?

Lock-and-key concept Signup and view all the answers

What does the pKa represent in physicochemical measurements?

Negative logarithm of the equilibrium constant Signup and view all the answers

In which direction does the equilibrium lie for a strong acid with a low pKa in water?

To the right Signup and view all the answers

What does a high pKa value imply for a weak acid in water?

Equilibrium lies to the left Signup and view all the answers

Why does hydrochloric acid with a Ka of 1.26 x 10^6 have essentially no unreacted HCl left in solution?

Large product of conjugate acid and base concentrations Signup and view all the answers

Why is tropicamide buffered near pH 4 for eye drop administration?

To minimize discomfort for the patient Signup and view all the answers

Which atom in indomethacin has acid-base properties in aqueous media?

Pyridine nitrogen Signup and view all the answers

Why is indomethacin preferred in a suspension dosage form buffered at pH 4 to 5?

To maintain its water solubility Signup and view all the answers

What is the dosage form of indomethacin used for intravenous administration to premature infants?

Salt form Signup and view all the answers

What is the general rule for determining a very weak acid?

pKa 8 to 10 Signup and view all the answers

In terms of ionization, how does ephedrine HCl compare to free ephedrine?

Ephedrine HCl is a poor proton acceptor, while free ephedrine is a strong proton donor. Signup and view all the answers

How can the drug's pKa value be utilized with respect to solubility in different media?

To increase solubility in water Signup and view all the answers

How are acids categorized based on ionic form and conjugate base properties?

HA acids transform into un-ionized conjugate bases, while BH+ acids change to polar conjugate bases. Signup and view all the answers

A chemical with a pKa value greater than 12 would result in which of the following properties?

Very weak acidic properties in water Signup and view all the answers

If a chemical has a pKa of 5, what can be inferred about its conjugate base properties?

Weak acidic properties in water Signup and view all the answers

Which type of acid would transition from un-ionized acids to ionized conjugate bases?

HA acids Signup and view all the answers

How does free ephedrine (conjugate base) behave in terms of accepting protons?

It is an excellent proton donor Signup and view all the answers