Podcast
Questions and Answers
What is one of the factors that play a crucial role in the biological activity of drugs?
What is one of the factors that play a crucial role in the biological activity of drugs?
- 3D shape of the molecule (correct)
- Type of packaging used for the drug
- Color of the drug
- Country of origin of the drug
How is the fit of drugs onto macromolecules described in the text?
How is the fit of drugs onto macromolecules described in the text?
- Continuous process (correct)
- All-or-none process
- Random process
- Intermittent process
What can cause significant changes in biological activity?
What can cause significant changes in biological activity?
- Changing the brand name
- Very slight changes in structure (correct)
- Radical changes in color
- Increasing the packaging size
What concept was used to explain why certain structural features produce predictable pharmacological actions?
What concept was used to explain why certain structural features produce predictable pharmacological actions?
What does the pKa represent in physicochemical measurements?
What does the pKa represent in physicochemical measurements?
In which direction does the equilibrium lie for a strong acid with a low pKa in water?
In which direction does the equilibrium lie for a strong acid with a low pKa in water?
What does a high pKa value imply for a weak acid in water?
What does a high pKa value imply for a weak acid in water?
Why does hydrochloric acid with a Ka of 1.26 x 10^6 have essentially no unreacted HCl left in solution?
Why does hydrochloric acid with a Ka of 1.26 x 10^6 have essentially no unreacted HCl left in solution?
Why is tropicamide buffered near pH 4 for eye drop administration?
Why is tropicamide buffered near pH 4 for eye drop administration?
Which atom in indomethacin has acid-base properties in aqueous media?
Which atom in indomethacin has acid-base properties in aqueous media?
Why is indomethacin preferred in a suspension dosage form buffered at pH 4 to 5?
Why is indomethacin preferred in a suspension dosage form buffered at pH 4 to 5?
What is the dosage form of indomethacin used for intravenous administration to premature infants?
What is the dosage form of indomethacin used for intravenous administration to premature infants?
What is the general rule for determining a very weak acid?
What is the general rule for determining a very weak acid?
In terms of ionization, how does ephedrine HCl compare to free ephedrine?
In terms of ionization, how does ephedrine HCl compare to free ephedrine?
How can the drug's pKa value be utilized with respect to solubility in different media?
How can the drug's pKa value be utilized with respect to solubility in different media?
How are acids categorized based on ionic form and conjugate base properties?
How are acids categorized based on ionic form and conjugate base properties?
A chemical with a pKa value greater than 12 would result in which of the following properties?
A chemical with a pKa value greater than 12 would result in which of the following properties?
If a chemical has a pKa of 5, what can be inferred about its conjugate base properties?
If a chemical has a pKa of 5, what can be inferred about its conjugate base properties?
Which type of acid would transition from un-ionized acids to ionized conjugate bases?
Which type of acid would transition from un-ionized acids to ionized conjugate bases?
How does free ephedrine (conjugate base) behave in terms of accepting protons?
How does free ephedrine (conjugate base) behave in terms of accepting protons?
