Enzymes: Concepts Lecture 9 BCMB 401 Spring 2024

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What is the main function of a catalyst in a chemical reaction?

Accelerates the reaction rate without being consumed

What percentage of proteins in a typical cell are enzymes?

10-20%

Which type of molecules are coenzymes often derived from?

Vitamins

What provides the specificity of enzyme-substrate interactions?

The shape of the enzyme active site

What parameter determines whether a biological reaction will occur spontaneously?

$ΔG_{ ext{o}}$ (standard biological free energy)

Which type of reaction requires energy input?

Endergonic

What do enzymes alter in a reaction?

Reaction rate

What is the relationship between the standard free energy change and the equilibrium constant as per the text?

Inversely proportional

What is the effect of enzymes on the equilibrium point of a reaction?

Does not affect the equilibrium point

Which factor determines the reaction equilibrium according to the text?

Free energy difference

What does ΔG°' being path independent mean?

It is not influenced by the reaction pathway

What does ΔG‡ represent in a reaction?

Energy needed to reach the transition state

How do enzymes lower the activation energy of a reaction?

By distorting the substrate

What is the role of the active site in enzymes?

To bind reversibly to substrate molecules

Why do enzymes exhibit high specificity at their active sites?

As a result of chemical complementarity

What is the main function of enzyme-substrate interactions at the active site?

To stabilize the transition state

Why are hydrogen bonds between an enzyme and substrate significant?

They strengthen enzyme-substrate interactions

What is one way enzymes can lower activation energy?

By making favorable interactions with the transition state

Which molecular structure is X‡ along a reaction pathway?

Transition state

This quiz covers the concepts of enzymes as biological catalysts, including their role in accelerating reaction rates without being consumed. Topics include enzyme specificity, the prevalence of enzymes as proteins in cells, and examples like carbonic anhydrase.

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