5 Questions
What happens to the enzyme when an inhibitor is bound?
The enzyme is inactivated
Does the presence of substrate affect the inactivation of the enzyme by an inhibitor?
No, it has no impact on inactivation
How does the binding of an inhibitor affect the enzyme's activity?
Decreases enzyme activity
In the presence of an inhibitor, what happens to the enzyme-substrate complex?
It dissociates more slowly
What effect does the binding of an inhibitor have on substrate binding to the enzyme?
Slows down substrate binding
Study Notes
Enzyme Inhibition
- Competitive inhibition prevents the substrate from binding to the enzyme's active site.
- High substrate concentrations can overcome competitive inhibition by replacing the inhibitor from the enzyme's active site.
Irreversible Inhibitors
- Irreversible inhibitors are molecules that permanently inactivate an enzyme.
- Kinetics of irreversible inhibitors:
- Vmax (maximum reaction rate) decreases.
- Km (Michaelis constant) remains unaffected.
Test your knowledge on how competitive inhibition affects enzyme-substrate reactions and how high substrate concentration can displace inhibitors from the active site.
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