10 Questions
What is the result of a substrate being converted into a product at an accelerated rate in an enzyme reaction?
Decreased activation energy
Which type of enzyme inhibitors act only on one enzyme or a small group of enzymes?
Specific inhibitors
What is the characteristic of irreversible inhibitors?
They bond covalently to a particular group at the enzyme
What is the main goal of most drug therapy based on enzyme inhibition?
Inhibiting the activity of the enzymes
Which model describes how an enzyme undergoes a conformational change to optimally interact with the substrate?
Induced fit model
Which type of irreversible inhibitor is considered unsuitable for therapeutic purposes?
Noncompetitive inhibitors
What is the main characteristic that distinguishes competitive inhibitors from noncompetitive inhibitors?
Binding to the active site of the enzyme
Which type of inhibitor binds to a site away from the active site, causing conformational changes in the enzyme?
Allosteric inhibitors
What does an increase in plasma concentrations of enzymes indicate?
Increased rate of release from tissues due to tissue damage
Which inhibitor competes for the active site with the substrate and can be reversed by increasing the substrate concentration?
Competitive inhibitors
Test your knowledge about enzyme inhibition, clinical significance of enzymes, and normal enzyme reaction. Learn about the substrate binding to the enzyme, enzyme-substrate complex formation, and the induced fit model.
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