10 Questions
Which type of inhibitor competes with the substrate for the active site of the enzyme?
Competitive inhibitors
Which type of inhibitor binds to a specific site away from the active site, causing conformational changes in the enzyme?
Allosteric inhibitors
What is the mechanism by which noncompetitive inhibitors inhibit enzyme activity?
By altering the shape of the enzyme
Which type of inhibitor binds to the enzyme or represses the gene coding for the enzyme, inhibiting the biosynthetic pathway?
Feedback inhibitors
What is indicative of increased rate of release from the tissues in plasma enzymes of clinical significance?
Increase in plasma concentrations
What is the main effect of enzyme inhibition?
Decrease or cessation in enzyme activity
Which type of inhibitor acts on only one enzyme or a small group of enzymes?
Specific inhibitors
How do irreversible inhibitors affect enzymes?
They cause irreversible inactivation of the enzymes
Which classification of enzyme inhibitors affects a wide variety of enzymes?
Non specific inhibitors
What is the result of substrate binding to an enzyme via the active site?
Causes an accelerated conversion of substrate into product
Test your knowledge of enzyme inhibition, clinical significance of enzymes, and normal enzyme reactions. Understand how a substrate binds to an enzyme, forming an enzyme-substrate complex, and how the induced fit model affects chemical bonds within the substrate.
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