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Enzyme Inhibition and Proteasome Pathway Quiz

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Enzyme Inhibition and Proteasome Pathway Quiz

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Questions and Answers

What is a defining characteristic of irreversible enzyme inhibition?

Involves reversible bonding with the enzyme

Can be overcome with high substrate concentrations

Requires new protein synthesis for recovery (correct)

Usually results from non-covalent modification of the enzyme

Which enzyme inhibitor forms a covalent bond with a bacterial transpeptidase?

Aspirin

COX-1

Chymotrypsin

Penicillin (correct)

What is the impact of irreversible enzyme inhibition on enzyme activity?

Enhances enzyme activity

Reverses enzyme activity

Completely blocks enzyme activity (correct)

Temporarily inhibits enzyme activity

How does aspirin function as an irreversible enzyme inhibitor?

Transfers an acetyl group to Serine 530 in COX-1 Signup and view all the answers

Why can irreversible enzyme inhibitors only be overcome by new protein synthesis?

The inhibitors permanently modify the enzyme's active site Signup and view all the answers

What is one objective of today's lecture?

To enable you to describe multiple myeloma and its treatment with a proteasome inhibitor Signup and view all the answers

What are the two main types of enzyme inhibition discussed?

Competitive and non-competitive Signup and view all the answers

How can enzymes be inhibited?

By drugs or as part of their normal regulation Signup and view all the answers

What is the clinical relevance of discussing how proteins are destroyed?

It is important for treating patients with enzyme inhibitors Signup and view all the answers

What can physicians do with enzyme inhibitors according to the text?

They can prescribe enzyme inhibitors and buy them over the counter Signup and view all the answers