Enzyme Inhibition and Proteasome Pathway Quiz
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Questions and Answers

What is a defining characteristic of irreversible enzyme inhibition?

  • Involves reversible bonding with the enzyme
  • Can be overcome with high substrate concentrations
  • Requires new protein synthesis for recovery (correct)
  • Usually results from non-covalent modification of the enzyme
  • Which enzyme inhibitor forms a covalent bond with a bacterial transpeptidase?

  • Aspirin
  • COX-1
  • Chymotrypsin
  • Penicillin (correct)
  • What is the impact of irreversible enzyme inhibition on enzyme activity?

  • Enhances enzyme activity
  • Reverses enzyme activity
  • Completely blocks enzyme activity (correct)
  • Temporarily inhibits enzyme activity
  • How does aspirin function as an irreversible enzyme inhibitor?

    <p>Transfers an acetyl group to Serine 530 in COX-1</p> Signup and view all the answers

    Why can irreversible enzyme inhibitors only be overcome by new protein synthesis?

    <p>The inhibitors permanently modify the enzyme's active site</p> Signup and view all the answers

    What is one objective of today's lecture?

    <p>To enable you to describe multiple myeloma and its treatment with a proteasome inhibitor</p> Signup and view all the answers

    What are the two main types of enzyme inhibition discussed?

    <p>Competitive and non-competitive</p> Signup and view all the answers

    How can enzymes be inhibited?

    <p>By drugs or as part of their normal regulation</p> Signup and view all the answers

    What is the clinical relevance of discussing how proteins are destroyed?

    <p>It is important for treating patients with enzyme inhibitors</p> Signup and view all the answers

    What can physicians do with enzyme inhibitors according to the text?

    <p>They can prescribe enzyme inhibitors and buy them over the counter</p> Signup and view all the answers

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