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Questions and Answers
Enzyme inhibitor (I) is a compound that binds to an enzyme and interferes with its ______
Enzyme inhibitor (I) is a compound that binds to an enzyme and interferes with its ______
activity
Inhibitor binds to enzyme (EI) to prevent the formation of the ES ______
Inhibitor binds to enzyme (EI) to prevent the formation of the ES ______
complex
Enzyme inhibition affects the rate/velocity of ______
Enzyme inhibition affects the rate/velocity of ______
reaction
The kinetics slows down/plateau because the complex ES becomes filled at high substrate concentration, leading to the formation of ______
The kinetics slows down/plateau because the complex ES becomes filled at high substrate concentration, leading to the formation of ______
5-fluorouracil is a ______ inhibitor of thymidilate synthase
5-fluorouracil is a ______ inhibitor of thymidilate synthase
Allopurinol is a ______ inhibitor of xanthine oxidase
Allopurinol is a ______ inhibitor of xanthine oxidase
Coumadin is a ______ inhibitor of Gglutamylcarboxylase
Coumadin is a ______ inhibitor of Gglutamylcarboxylase
Reversible Competitive inhibitor: structure resembles the substrate and binds to the same site as the substrate, causing the enzyme to be unable to bind to the substrate and therefore no reaction occurs. This type of inhibitor is known as a ______ inhibitor.
Reversible Competitive inhibitor: structure resembles the substrate and binds to the same site as the substrate, causing the enzyme to be unable to bind to the substrate and therefore no reaction occurs. This type of inhibitor is known as a ______ inhibitor.
Non-competitive inhibitor does not bind to the same site as the substrate, allowing the substrate to still bind to the enzyme but no reaction will occur as the inhibitor alters the ______ of the enzyme.
Non-competitive inhibitor does not bind to the same site as the substrate, allowing the substrate to still bind to the enzyme but no reaction will occur as the inhibitor alters the ______ of the enzyme.
Uncompetitive inhibitor binds to the ES complex only, preventing the formation of the product, leading to no ______ occurring.
Uncompetitive inhibitor binds to the ES complex only, preventing the formation of the product, leading to no ______ occurring.
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Study Notes
Enzyme Inhibition
- Enzyme inhibitor binds to an enzyme and interferes with its function.
- Inhibitor binds to enzyme (EI) to prevent the formation of the ES complex.
- Enzyme inhibition affects the rate/velocity of the reaction.
Types of Inhibitors
- 5-fluorouracil is a competitive inhibitor of thymidilate synthase.
- Allopurinol is a competitive inhibitor of xanthine oxidase.
- Coumadin is a competitive inhibitor of Gglutamylcarboxylase.
Characteristics of Inhibitors
- Reversible Competitive inhibitor: structure resembles the substrate and binds to the same site as the substrate, preventing the enzyme from binding to the substrate.
- Reversible Competitive inhibitor is known as a substrate analogue inhibitor.
- Non-competitive inhibitor does not bind to the same site as the substrate, allowing the substrate to still bind to the enzyme but altering the enzyme's conformation, preventing the reaction from occurring.
- Uncompetitive inhibitor binds to the ES complex only, preventing the formation of the product, leading to no reaction occurring.
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