18 Questions
What is one of the mechanisms by which environmental factors induce autoimmunity?
Epigenetic changes
What is the result of exposure of DNA and small nuclear ribonucleoproteins to UV-B radiation?
Changes to the conformation and location of DNA and snRNPs
What is the effect of environmental toxins on the immune system?
Activation of autoreactive lymphocytes
What is the link between certain chemical agents and autoimmune diseases?
They trigger the onset of particular systemic symptoms
What is the primary reason for interpreting findings at diagnosis with findings at initiation?
To understand the development of ADs
What is the result of exposure to UV radiation in patients with SLE?
Flare-ups of disease
How many phases are involved in the development of ADs?
Four
What is the role of epigenetic changes in autoimmune diseases?
They contribute to the development of autoimmune diseases
What can trigger the initiation phase of ADs?
Abnormalities in tolerance induction
What is the characteristic of the propagation phase of ADs?
Feed-forward cycle of autoimmunity and tissue damage
What can occur during the propagation phase of ADs?
Immunoregulatory pathways activation
How are ADs usually categorized?
As organ-specific or systemic or both
What type of infections can provoke the initiation of systemic autoimmune diseases in genetically predisposed individuals?
Viral, bacterial, and mycoplasma infections
What can a severe bacterial or viral infection trigger in individuals with autoimmune diseases?
An increase in autoreactive antibodies
What is a common feature of many autoimmune diseases in both humans and experimental animal models?
Females are more susceptible to autoimmune conditions
What do researchers hypothesize about the role of hormones in autoimmune diseases?
Hormones play a significant role in the sex-based susceptibility to autoimmune diseases
What is often abnormal in patients with systemic lupus erythematosus (SLE)?
Estrogen metabolism
What is a characteristic of many autoimmune diseases in terms of regional and ethnic differences?
They vary in incidence by region or ethnic group
This quiz explores the connections between environmental stimuli and the onset or exacerbation of autoimmune diseases, including the impact of chemical agents and pathogens on AD symptoms. Learn about the specific toxins and substances that have been linked to immune complex nephritis, systemic sclerosis, and autoantibody development. Test your knowledge of the environmental factors that contribute to autoimmune diseases.
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