Environmental Factors in Autoimmune Diseases

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18 Questions

What is one of the mechanisms by which environmental factors induce autoimmunity?

Epigenetic changes

What is the result of exposure of DNA and small nuclear ribonucleoproteins to UV-B radiation?

Changes to the conformation and location of DNA and snRNPs

What is the effect of environmental toxins on the immune system?

Activation of autoreactive lymphocytes

What is the link between certain chemical agents and autoimmune diseases?

They trigger the onset of particular systemic symptoms

What is the primary reason for interpreting findings at diagnosis with findings at initiation?

To understand the development of ADs

What is the result of exposure to UV radiation in patients with SLE?

Flare-ups of disease

How many phases are involved in the development of ADs?


What is the role of epigenetic changes in autoimmune diseases?

They contribute to the development of autoimmune diseases

What can trigger the initiation phase of ADs?

Abnormalities in tolerance induction

What is the characteristic of the propagation phase of ADs?

Feed-forward cycle of autoimmunity and tissue damage

What can occur during the propagation phase of ADs?

Immunoregulatory pathways activation

How are ADs usually categorized?

As organ-specific or systemic or both

What type of infections can provoke the initiation of systemic autoimmune diseases in genetically predisposed individuals?

Viral, bacterial, and mycoplasma infections

What can a severe bacterial or viral infection trigger in individuals with autoimmune diseases?

An increase in autoreactive antibodies

What is a common feature of many autoimmune diseases in both humans and experimental animal models?

Females are more susceptible to autoimmune conditions

What do researchers hypothesize about the role of hormones in autoimmune diseases?

Hormones play a significant role in the sex-based susceptibility to autoimmune diseases

What is often abnormal in patients with systemic lupus erythematosus (SLE)?

Estrogen metabolism

What is a characteristic of many autoimmune diseases in terms of regional and ethnic differences?

They vary in incidence by region or ethnic group

This quiz explores the connections between environmental stimuli and the onset or exacerbation of autoimmune diseases, including the impact of chemical agents and pathogens on AD symptoms. Learn about the specific toxins and substances that have been linked to immune complex nephritis, systemic sclerosis, and autoantibody development. Test your knowledge of the environmental factors that contribute to autoimmune diseases.

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