18 Questions
What is the process of de novo formation of blood vessels by endothelial progenitor cells during the early mammalian embryo and yolk sac?
Vasculogenesis
Which factor is not mentioned as being involved in the development of the vascular system?
FGF
What occurs during angiogenesis?
Expansion of new vessels from an existing network
Which factor plays a crucial role in the diffusion limit of oxygen in tissues?
VEGF
What can be a consequence of thicker constructs in tissue engineering without sufficient vascularization?
Cell necrosis
What is the expansion of new vessels from an existing vascular network called?
Angiogenesis
What is a key aspect of scaffold design for vascularization in tissue constructs?
Patterning the vascular network
Which in vitro approach involves the incorporation of endothelial cells for prevascularization?
Vascular cell co-cultures
What approach relies on angiogenesis in vivo for vascularization?
Letting the body perform the job
What is a key aspect of functional vascularization of engineered tissue constructs?
Maturation and organization of the vascular tree
Which factor has a pivotal role in controlling and modulating tissues and organs in the body?
Innervation
What is crucial for the implant success when considering the interplay with the immune system?
Responding to immune signals appropriately
What is the role of Th2 cells in the immune response to biomaterial implants?
Enhance wound healing and constructive remodelling
How can chronic inflammation be modulated in the context of construct implantation?
Administering anti-inflammatory drugs
Which cell type plays a crucial role in immunological acceptance of engineered tissues?
Mesenchymal stem cells (MSCs)
What is a key factor leading to implant rejection?
Immunological response to biomaterials
How does encapsulation of the TE construct impact implant success?
Isolates the construct from host tissue and vasculature
In the context of scaffold design, what is a critical consideration for promoting biocompatibility?
Enhancing vascularization
Test your knowledge on engineered tissue constructs and vascularization strategies, including scaffold design, in vitro prevascularization techniques, and in vivo approaches for creating vascular networks. This quiz covers topics such as endothelial cell incorporation, vascular cell co-cultures, and 3D cell spheroids.
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