Engineered Tissue Constructs Vascularization Strategies Quiz
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Questions and Answers

What is the process of de novo formation of blood vessels by endothelial progenitor cells during the early mammalian embryo and yolk sac?

  • Vasculogenesis (correct)
  • Angiogenesis
  • Endothelial maturation
  • Pericytes proliferation
  • Which factor is not mentioned as being involved in the development of the vascular system?

  • VEGF
  • FGF (correct)
  • PDGF
  • S1P
  • What occurs during angiogenesis?

  • Isolation of endothelial progenitor cells
  • Maturation of smooth muscle cells
  • Formation of a primitive vascular plexus
  • Expansion of new vessels from an existing network (correct)
  • Which factor plays a crucial role in the diffusion limit of oxygen in tissues?

    <p>VEGF</p> Signup and view all the answers

    What can be a consequence of thicker constructs in tissue engineering without sufficient vascularization?

    <p>Cell necrosis</p> Signup and view all the answers

    What is the expansion of new vessels from an existing vascular network called?

    <p>Angiogenesis</p> Signup and view all the answers

    What is a key aspect of scaffold design for vascularization in tissue constructs?

    <p>Patterning the vascular network</p> Signup and view all the answers

    Which in vitro approach involves the incorporation of endothelial cells for prevascularization?

    <p>Vascular cell co-cultures</p> Signup and view all the answers

    What approach relies on angiogenesis in vivo for vascularization?

    <p>Letting the body perform the job</p> Signup and view all the answers

    What is a key aspect of functional vascularization of engineered tissue constructs?

    <p>Maturation and organization of the vascular tree</p> Signup and view all the answers

    Which factor has a pivotal role in controlling and modulating tissues and organs in the body?

    <p>Innervation</p> Signup and view all the answers

    What is crucial for the implant success when considering the interplay with the immune system?

    <p>Responding to immune signals appropriately</p> Signup and view all the answers

    What is the role of Th2 cells in the immune response to biomaterial implants?

    <p>Enhance wound healing and constructive remodelling</p> Signup and view all the answers

    How can chronic inflammation be modulated in the context of construct implantation?

    <p>Administering anti-inflammatory drugs</p> Signup and view all the answers

    Which cell type plays a crucial role in immunological acceptance of engineered tissues?

    <p>Mesenchymal stem cells (MSCs)</p> Signup and view all the answers

    What is a key factor leading to implant rejection?

    <p>Immunological response to biomaterials</p> Signup and view all the answers

    How does encapsulation of the TE construct impact implant success?

    <p>Isolates the construct from host tissue and vasculature</p> Signup and view all the answers

    In the context of scaffold design, what is a critical consideration for promoting biocompatibility?

    <p>Enhancing vascularization</p> Signup and view all the answers

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