26 Questions
Which of the following receptors is NOT involved in the classical renin-angiotensin system pathway?
PRR
What is the primary function of Angiotensin Converting Enzyme-1 (ACE-1)?
To cleave dipeptide units from substrates with diverse amino acid sequences
What is a characteristic of preferred substrates for Angiotensin Converting Enzyme-1 (ACE-1)?
They must have only one free carboxyl group in the carboxylterminal amino acid
What is the effect of Angiotensin Converting Enzyme-1 (ACE-1) on bradykinin?
It inactivates bradykinin
Where is Angiotensin Converting Enzyme-1 (ACE-1) primarily found?
Circulating in plasma and on the surface of various cell types
Which of the following is NOT a receptor involved in the renin-angiotensin system?
AP
What is the primary substrate for ACE-2?
Angiotensin II
What is the function of angiotensinogen in the RAS?
It is the substrate for renin
What is the effect of Angiotensin (1-7) on the kidneys?
It has a natriuretic effect
What is the primary receptor activated by Angiotensin (1-7)?
Mas receptors
What is the effect of ACE-2 on Angiotensin II plasma concentrations?
It decreases Angiotensin II plasma concentrations
What is the role of ACE-1 in the RAS?
It converts Angiotensin I to Angiotensin II
What is the effect of Angiotensin II on blood vessels?
It causes vasoconstriction
What is the effect of ACE inhibitors on the RAS?
They decrease Angiotensin II plasma concentrations
What is the structure of Angiotensin I?
A decapeptide
What is the effect of angiotensin III on blood vessels?
It causes vasoconstriction
What is the effect of angiotensin II on cardiac contractility?
It may increase, decrease, or not change cardiac contractility
What is the result of the rapid pressor response to angiotensin II?
An increase in total peripheral resistance
What is the site of action for the slow pressor response to angiotensin II?
The kidneys
What is the effect of angiotensin II on the reuptake of norepinephrine?
It inhibits the reuptake of norepinephrine
What is the effect of angiotensin II on the release of catecholamines?
It stimulates the release of catecholamines
What is the effect of angiotensin II on Na+ reabsorption in the proximal tubule?
It increases Na+ reabsorption
What is the effect of angiotensin II on aldosterone secretion?
It stimulates aldosterone secretion
What is the effect of angiotensin II on renal blood flow?
It reduces renal blood flow
What is the role of the renin-angiotensin system in altered cardiovascular structure?
It contributes significantly to altered cardiovascular structure
What is the mechanism by which angiotensin II contributes to cardiac hypertrophy?
All of the above
Learn about the components of the Renin-Angiotensin System, including Angiotensin Converting Enzyme-2 (ACE-2) and its role in the body. Understand how ACE-2 serves as a receptor for SARS-CoV2 and other respiratory viruses. Test your knowledge of the RAS and its functions.
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