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Parathyroid Glands

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What is the typical location of the parathyroid glands in most species?

At the poles of the thyroid glands

Which type of cells in the parathyroid gland are involved in the synthesis and secretion of PTH?

Parathyroid chief cells

How are protein and peptide hormones like PTH usually synthesized?

Inactive molecule in the ER, prohormone in Golgi apparatus, then hormone

Which hormone is associated with stimulating osteoclast activity for bone resorption?

<p>PTH</p> Signup and view all the answers

What is the primary function of calcitriol in calcium metabolism?

<p>Enhancing calcium absorption from the intestines</p> Signup and view all the answers

Which term refers to an abnormally high level of calcium in the blood?

<p>Hypercalcemia</p> Signup and view all the answers

What stimulates the release of PTH (Parathormone) from chief cells?

<p>Decrease in blood ionized calcium (hypocalcemia)</p> Signup and view all the answers

Where is Prepro-PTH synthesized before being cleaved to pro-PTH?

<p>rER (rough endoplasmic reticulum)</p> Signup and view all the answers

What is the main function of Oxphil cells in the parathyroid gland?

<p>Unknown function</p> Signup and view all the answers

Which organelle removes the 'pro' portion from prepro-PTH to form active PTH?

<p>Golgi apparatus</p> Signup and view all the answers

What type of receptors are present on the parathyroid gland membrane to sense changes in blood ionized calcium?

<p>G-Protein coupled receptors</p> Signup and view all the answers

What is the half-life of Parathormone (PTH) once it is secreted?

<p>5-10 minutes</p> Signup and view all the answers

What is the general location of the parathyroid glands in relation to the thyroid glands?

<p>Within the lobes of the thyroid glands</p> Signup and view all the answers

Which type of cells in the parathyroid gland are primarily responsible for the synthesis and secretion of PTH?

<p>Parathyroid chief cells</p> Signup and view all the answers

In what form is PTH usually synthesized and stored within the parathyroid gland before secretion?

<p>Prohormone</p> Signup and view all the answers

What is the major role of calcitriol in calcium metabolism?

<p>Promoting calcium reabsorption in the kidneys</p> Signup and view all the answers

Which of the following correctly represents the synthesis process of most protein and peptide hormones, including PTH?

<p>Inactive molecule in the ER</p> Signup and view all the answers

What is meant by hypercalcemia?

<p>High level of calcium in blood</p> Signup and view all the answers

What stimulates the release of PTH (Parathormone) from chief cells in the parathyroid gland?

<p>Increase in blood ionized calcium levels</p> Signup and view all the answers

Which organelle is responsible for the removal of the 'pro' portion from prepro-PTH to form active PTH in the parathyroid gland?

<p>Golgi apparatus</p> Signup and view all the answers

What is the main function of phosphate (PO4) in physiological homeostasis as it relates to the parathyroid gland?

<p>Buffer system in blood coagulation</p> Signup and view all the answers

What happens to PTH (Parathormone) once it is secreted from the parathyroid gland?

<p>Metabolized by liver and kidneys</p> Signup and view all the answers

Which cells in the parathyroid gland are larger than chief cells and have unknown function but exhibit enzymatic activities?

<p>Oxyphil cells</p> Signup and view all the answers

What is the main role of calcium in blood coagulation and enzyme activation as related to the parathyroid gland?

<p>Activation of several enzymes</p> Signup and view all the answers

What is the typical number of pairs of parathyroid glands found in most species?

<p>Two pairs</p> Signup and view all the answers

Which type of cells in the parathyroid gland have larger size than chief cells and exhibit enzymatic activities, yet their function remains unknown?

<p>Oxyphil cells</p> Signup and view all the answers

In the synthesis pathway, what is the state of Parathyroid Hormone (PTH) when it is stored within the parathyroid gland awaiting secretion?

<p>Inactive prohormone</p> Signup and view all the answers

Where in the cell does the cleavage from prepro-PTH to pro-PTH typically occur before packaging into secretory granules for secretion?

<p>Golgi apparatus</p> Signup and view all the answers

Which term refers to an abnormally low level of calcium in the blood?

<p>Hypocalcemia</p> Signup and view all the answers

What is the primary function of Calcitonin as it relates to calcium and phosphate homeostasis?

<p>Inhibiting bone resorption by osteoclasts</p> Signup and view all the answers

What is the primary function of Oxphil cells in the parathyroid gland?

<p>Unknown function, but exhibit enzymatic activities</p> Signup and view all the answers

Which organelle is responsible for the synthesis and cleavage of prepro-PTH to form pro-PTH in the parathyroid gland?

<p>Endoplasmic reticulum (rER)</p> Signup and view all the answers

What stimulates the release of PTH from chief cells in the parathyroid gland?

<p>Hypocalcemia</p> Signup and view all the answers

Which of the following is NOT a function of calcium in physiological homeostasis as it relates to the parathyroid gland?

<p>Synthesis of phosphate (PO4)</p> Signup and view all the answers

What is the main role of phosphate (PO4) in physiological homeostasis as it relates to the parathyroid gland?

<p>Activation of several enzymes</p> Signup and view all the answers

Which type of receptors are present on the parathyroid gland membrane to sense changes in blood ionized calcium?

<p>G-Protein coupled receptors</p> Signup and view all the answers

What is the typical number of pairs of parathyroid glands found in most species?

<p>Two pairs</p> Signup and view all the answers

Which hormone is associated with stimulating osteoclast activity for bone resorption?

<p>Parathyroid Hormone (PTH)</p> Signup and view all the answers

What is the half-life of Parathormone (PTH) once it is secreted?

<p>6 hours</p> Signup and view all the answers

Where are the parathyroid glands usually located in most species?

<p>At the poles of the thyroid glands</p> Signup and view all the answers

What stimulates the release of Parathyroid Hormone (PTH) from chief cells in the parathyroid gland?

<p>Hypocalcemia</p> Signup and view all the answers

What is the primary function of Oxphil cells in the parathyroid gland?

<p>Unknown function</p> Signup and view all the answers

What is the main function of Oxphil cells in the parathyroid gland?

<p>Secretion of enzymes for digestion</p> Signup and view all the answers

What happens to the blood PTH levels when there is an increase in blood ionized calcium?

<p>Secretion of PTH decreases</p> Signup and view all the answers

Which organelle is responsible for the metabolism of Parathormone (PTH) after secretion?

<p>Golgi Apparatus</p> Signup and view all the answers

What is the primary role of Calcium and Phosphate in the context of muscle contraction and nerve cell activity?

<p>Composition of cell membrane</p> Signup and view all the answers

How does the parathyroid gland respond to hypocalcemia?

<p>Release of PTH increases</p> Signup and view all the answers

Which process occurs in the Golgi apparatus before Parathormone (PTH) is secreted by exocytosis?

<p>'Pro' portion removal from pro-PTH</p> Signup and view all the answers

What is the main gland involved in Calcium and Phosphate metabolism?

<p>Parathyroid Gland</p> Signup and view all the answers

What is the role of calcium and phosphate in blood coagulation and enzyme activation as related to the parathyroid gland?

<p>Maintain structural integrity of bones and teeth</p> Signup and view all the answers

Which organelle is responsible for the metabolism of Parathormone (PTH) after secretion?

<p>Lysosome</p> Signup and view all the answers

What is the primary function of Oxphil cells in the parathyroid gland?

<p>Unknown function</p> Signup and view all the answers

What stimulates the release of PTH (Parathormone) from chief cells in the parathyroid gland?

<p>Hypocalcemia</p> Signup and view all the answers

Where are the parathyroid glands usually located in most species?

<p>Near the thyroid glands</p> Signup and view all the answers

What is the main role of calcium in muscle contraction and nerve cell activity as related to the parathyroid gland?

<p>Facilitate neurotransmitter release</p> Signup and view all the answers

How are protein and peptide hormones like PTH usually synthesized?

<p>In endoplasmic reticulum</p> Signup and view all the answers

What stimulates the release of PTH (Parathormone) from chief cells?

<p>Hypocalcemia</p> Signup and view all the answers

Which organelle is responsible for the synthesis and cleavage of prepro-PTH to form pro-PTH in the parathyroid gland?

<p>Endoplasmic reticulum</p> Signup and view all the answers

What occurs before Parathormone (PTH) is secreted by exocytosis?

<p>Removal of 'pro' portion in Golgi apparatus</p> Signup and view all the answers

What is the primary role of parathyroid hormones on target tissues/organs?

<p>Activating osteoclasts for bone resorption</p> Signup and view all the answers

Which molecule is usually synthesized as an inactive molecule in the ER before being cleaved into its active form in the Golgi apparatus?

<p>Parathyroid hormone (PTH)</p> Signup and view all the answers

What is the relationship between PTH and calcitonin in maintaining calcium and phosphate homeostasis?

<p>PTH and calcitonin have opposing effects on blood calcium levels</p> Signup and view all the answers

What is the primary function of Parathyroid oxyphil cells within the parathyroid gland?

<p>Maintaining bone canaliculi</p> Signup and view all the answers

How does PTH affect calcitriol activation and its importance in calcium metabolism?

<p>Promotes calcitriol activation to increase calcium absorption</p> Signup and view all the answers

What is the main physiological relevance of calcium and phosphate to maintain body homeostasis?

<p>Regulate key biological functions like muscle contraction and nerve impulses</p> Signup and view all the answers

Which organelle is responsible for packaging pre-prohormones into secretory granules before their secretion?

<p>Golgi apparatus</p> Signup and view all the answers

What is the macroanatomy description of the typical location of parathyroid glands in relation to the thyroid glands?

<p>Embedded in the lobes of the thyroid glands</p> Signup and view all the answers

What is the primary function of G-protein coupled receptors on the parathyroid gland membrane?

<p>Detect changes in blood ionized calcium levels</p> Signup and view all the answers

What happens to blood PTH levels when there is a decrease in blood ionized calcium?

<p>PTH levels increase to counter hypocalcemia</p> Signup and view all the answers

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