Cellular Biology: Adrenal Gland Functions - Part 2

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Questions and Answers

What is the main effect of cortisol on protein metabolism?

  • Increased muscle fiber synthesis
  • Reduced cellular protein synthesis (correct)
  • Promotion of connective tissue synthesis
  • Enhanced bone formation

Which of the following is a main substrate for gluconeogenesis catalyzed by cortisol?

  • Proteolytic enzymes by damaged cells
  • Insulin-like growth factor 1 (IGF-1)
  • Free fatty acids (FFAs) from adipose tissue
  • Amino acids from skeletal muscles (correct)

What is the role of cortisol in lipid metabolism?

  • Stimulates glucose transport into fat cells
  • Enhances peripheral fat deposition
  • Shifts metabolism from fat to glucose utilization (correct)
  • Decreases fatty acid mobilization from adipose tissue

Which hormone enables cortisol to potentiate the action of glucagon and epinephrine on glucose metabolism?

<p>Glucagon (A)</p> Signup and view all the answers

How does cortisol affect carbohydrate metabolism?

<p>Antagonizes insulin's effect on glucose synthesis (D)</p> Signup and view all the answers

Which hormone is primarily responsible for the 'fight or flight' response?

<p>Epinephrine (EPI) (B)</p> Signup and view all the answers

Which type of receptors are primarily targeted by catecholamines like epinephrine and norepinephrine?

<p>Adrenergic receptors (B)</p> Signup and view all the answers

'Addison's Disease' is characterized by hypoactivity of which gland?

<p>'Adrenal cortex' (C)</p> Signup and view all the answers

Which hormone is responsible for increasing libido and secondary sexual characteristics in humans?

<p>Androgens (A)</p> Signup and view all the answers

Which enzyme is responsible for the conversion of L-tyrosine to L-DOPA in the chromaffin cells?

<p>Tyrosine hydroxylase (B)</p> Signup and view all the answers

What is the primary mechanism by which norepinephrine exerts negative feedback on pre-ganglionic sympathetic neurons?

<p>Inhibiting the release of acetylcholine (D)</p> Signup and view all the answers

Which receptor subtype is primarily responsible for the vasoconstrictive effects of catecholamines on arterioles?

<p>Alpha-1 (D)</p> Signup and view all the answers

Which of the following is NOT a metabolic effect of catecholamine action?

<p>Increased protein synthesis in skeletal muscle (D)</p> Signup and view all the answers

Which enzyme is responsible for the conversion of dopamine to norepinephrine within the chromaffin granules?

<p>Dopamine beta-hydroxylase (B)</p> Signup and view all the answers

What is the primary mechanism by which catecholamines increase glucose availability during the fight-or-flight response?

<p>Promotion of glycogenolysis and gluconeogenesis (A)</p> Signup and view all the answers

Which adrenergic receptor subtype is primarily responsible for the positive chronotropic and inotropic effects of catecholamines on the heart?

<p>Beta-1 (A)</p> Signup and view all the answers

What is the primary mechanism by which catecholamines increase energy availability during the fight-or-flight response?

<p>Stimulation of lipolysis and fatty acid oxidation (C)</p> Signup and view all the answers

Which enzyme system is primarily responsible for the degradation and excretion of catecholamines?

<p>Catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO) (B)</p> Signup and view all the answers

Which of the following statements about the clearance half-life of catecholamines is correct?

<p>Dopamine has the longest half-life (B)</p> Signup and view all the answers

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