Cellular Biology: Adrenal Gland Functions - Part 2
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Questions and Answers

What is the main effect of cortisol on protein metabolism?

  • Increased muscle fiber synthesis
  • Reduced cellular protein synthesis (correct)
  • Promotion of connective tissue synthesis
  • Enhanced bone formation
  • Which of the following is a main substrate for gluconeogenesis catalyzed by cortisol?

  • Proteolytic enzymes by damaged cells
  • Insulin-like growth factor 1 (IGF-1)
  • Free fatty acids (FFAs) from adipose tissue
  • Amino acids from skeletal muscles (correct)
  • What is the role of cortisol in lipid metabolism?

  • Stimulates glucose transport into fat cells
  • Enhances peripheral fat deposition
  • Shifts metabolism from fat to glucose utilization (correct)
  • Decreases fatty acid mobilization from adipose tissue
  • Which hormone enables cortisol to potentiate the action of glucagon and epinephrine on glucose metabolism?

    <p>Glucagon</p> Signup and view all the answers

    How does cortisol affect carbohydrate metabolism?

    <p>Antagonizes insulin's effect on glucose synthesis</p> Signup and view all the answers

    Which hormone is primarily responsible for the 'fight or flight' response?

    <p>Epinephrine (EPI)</p> Signup and view all the answers

    Which type of receptors are primarily targeted by catecholamines like epinephrine and norepinephrine?

    <p>Adrenergic receptors</p> Signup and view all the answers

    'Addison's Disease' is characterized by hypoactivity of which gland?

    <p>'Adrenal cortex'</p> Signup and view all the answers

    Which hormone is responsible for increasing libido and secondary sexual characteristics in humans?

    <p>Androgens</p> Signup and view all the answers

    Which enzyme is responsible for the conversion of L-tyrosine to L-DOPA in the chromaffin cells?

    <p>Tyrosine hydroxylase</p> Signup and view all the answers

    What is the primary mechanism by which norepinephrine exerts negative feedback on pre-ganglionic sympathetic neurons?

    <p>Inhibiting the release of acetylcholine</p> Signup and view all the answers

    Which receptor subtype is primarily responsible for the vasoconstrictive effects of catecholamines on arterioles?

    <p>Alpha-1</p> Signup and view all the answers

    Which of the following is NOT a metabolic effect of catecholamine action?

    <p>Increased protein synthesis in skeletal muscle</p> Signup and view all the answers

    Which enzyme is responsible for the conversion of dopamine to norepinephrine within the chromaffin granules?

    <p>Dopamine beta-hydroxylase</p> Signup and view all the answers

    What is the primary mechanism by which catecholamines increase glucose availability during the fight-or-flight response?

    <p>Promotion of glycogenolysis and gluconeogenesis</p> Signup and view all the answers

    Which adrenergic receptor subtype is primarily responsible for the positive chronotropic and inotropic effects of catecholamines on the heart?

    <p>Beta-1</p> Signup and view all the answers

    What is the primary mechanism by which catecholamines increase energy availability during the fight-or-flight response?

    <p>Stimulation of lipolysis and fatty acid oxidation</p> Signup and view all the answers

    Which enzyme system is primarily responsible for the degradation and excretion of catecholamines?

    <p>Catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO)</p> Signup and view all the answers

    Which of the following statements about the clearance half-life of catecholamines is correct?

    <p>Dopamine has the longest half-life</p> Signup and view all the answers

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