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Cellular Biology: Adrenal Gland Functions - Part 2

This quiz covers topics related to the Adrenal Gland, focusing on glucocorticoids synthesis, negative feedback mechanisms of the HPA axis, effects of cortisol on metabolism, and the synthesis of adrenal sex hormones. It also discusses how cortisol impacts different tissues like skeletal muscle, liver, adipose tissue, and the immune system.

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@BetterSetting
1/19
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Questions and Answers

What is the main effect of cortisol on protein metabolism?

Reduced cellular protein synthesis

Which of the following is a main substrate for gluconeogenesis catalyzed by cortisol?

Amino acids from skeletal muscles

What is the role of cortisol in lipid metabolism?

Shifts metabolism from fat to glucose utilization

Which hormone enables cortisol to potentiate the action of glucagon and epinephrine on glucose metabolism?

<p>Glucagon</p> Signup and view all the answers

How does cortisol affect carbohydrate metabolism?

<p>Antagonizes insulin's effect on glucose synthesis</p> Signup and view all the answers

Which hormone is primarily responsible for the 'fight or flight' response?

<p>Epinephrine (EPI)</p> Signup and view all the answers

Which type of receptors are primarily targeted by catecholamines like epinephrine and norepinephrine?

<p>Adrenergic receptors</p> Signup and view all the answers

'Addison's Disease' is characterized by hypoactivity of which gland?

<p>'Adrenal cortex'</p> Signup and view all the answers

Which hormone is responsible for increasing libido and secondary sexual characteristics in humans?

<p>Androgens</p> Signup and view all the answers

Which enzyme is responsible for the conversion of L-tyrosine to L-DOPA in the chromaffin cells?

<p>Tyrosine hydroxylase</p> Signup and view all the answers

What is the primary mechanism by which norepinephrine exerts negative feedback on pre-ganglionic sympathetic neurons?

<p>Inhibiting the release of acetylcholine</p> Signup and view all the answers

Which receptor subtype is primarily responsible for the vasoconstrictive effects of catecholamines on arterioles?

<p>Alpha-1</p> Signup and view all the answers

Which of the following is NOT a metabolic effect of catecholamine action?

<p>Increased protein synthesis in skeletal muscle</p> Signup and view all the answers

Which enzyme is responsible for the conversion of dopamine to norepinephrine within the chromaffin granules?

<p>Dopamine beta-hydroxylase</p> Signup and view all the answers

What is the primary mechanism by which catecholamines increase glucose availability during the fight-or-flight response?

<p>Promotion of glycogenolysis and gluconeogenesis</p> Signup and view all the answers

Which adrenergic receptor subtype is primarily responsible for the positive chronotropic and inotropic effects of catecholamines on the heart?

<p>Beta-1</p> Signup and view all the answers

What is the primary mechanism by which catecholamines increase energy availability during the fight-or-flight response?

<p>Stimulation of lipolysis and fatty acid oxidation</p> Signup and view all the answers

Which enzyme system is primarily responsible for the degradation and excretion of catecholamines?

<p>Catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO)</p> Signup and view all the answers

Which of the following statements about the clearance half-life of catecholamines is correct?

<p>Dopamine has the longest half-life</p> Signup and view all the answers

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