Podcast
Questions and Answers
Which of the following is NOT typically a secondary condition associated with end-stage chronic kidney disease?
Which of the following is NOT typically a secondary condition associated with end-stage chronic kidney disease?
- Metabolic acidosis
- Anemia
- Hypertension
- Hypokalemia (correct)
Electrolyte imbalance is a common secondary condition in end-stage chronic kidney disease.
Electrolyte imbalance is a common secondary condition in end-stage chronic kidney disease.
True (A)
Define renal osteodystrophy and explain its relevance to chronic kidney disease.
Define renal osteodystrophy and explain its relevance to chronic kidney disease.
Renal osteodystrophy is a bone disease that occurs when the kidneys fail to maintain proper levels of calcium and phosphorus in the blood. It is relevant to chronic kidney disease because the failing kidneys are unable to activate vitamin D, which is needed for calcium absoprtion.
______ is a life-threatening condition related to potassium levels that can cause cardiac arrest/death.
______ is a life-threatening condition related to potassium levels that can cause cardiac arrest/death.
Match the secondary conditions with their related physiological imbalances in end-stage chronic kidney disease:
Match the secondary conditions with their related physiological imbalances in end-stage chronic kidney disease:
Azotemia, a condition associated with end-stage chronic kidney disease, is characterized by:
Azotemia, a condition associated with end-stage chronic kidney disease, is characterized by:
Depression is not typically observed as a secondary condition in patients with end-stage chronic kidney disease.
Depression is not typically observed as a secondary condition in patients with end-stage chronic kidney disease.
How does end-stage chronic kidney disease contribute to the development of hypertension?
How does end-stage chronic kidney disease contribute to the development of hypertension?
Which secondary condition of end-stage chronic kidney disease directly poses an immediate, life-threatening risk related to cardiac function?
Which secondary condition of end-stage chronic kidney disease directly poses an immediate, life-threatening risk related to cardiac function?
In renal osteodystrophy, the failing kidneys are unable to activate vitamin ______, needed for calcium absorption.
In renal osteodystrophy, the failing kidneys are unable to activate vitamin ______, needed for calcium absorption.
What is the primary reason for anemia in end-stage renal disease (ESRD)?
What is the primary reason for anemia in end-stage renal disease (ESRD)?
Uremia in ESRD can extend the lifespan of red blood cells.
Uremia in ESRD can extend the lifespan of red blood cells.
List three common symptoms associated with anemia in ESRD.
List three common symptoms associated with anemia in ESRD.
Renal osteodystrophy occurs because the kidneys fail to regulate __________ and __________, leading to weak bones.
Renal osteodystrophy occurs because the kidneys fail to regulate __________ and __________, leading to weak bones.
In renal osteodystrophy, what hormonal change leads to bone breakdown?
In renal osteodystrophy, what hormonal change leads to bone breakdown?
Match each condition with its primary cause in ESRD:
Match each condition with its primary cause in ESRD:
High phosphorus and high calcium levels lead to increased parathyroid hormone in ESRD
High phosphorus and high calcium levels lead to increased parathyroid hormone in ESRD
Which electrolyte imbalance contributes to increased parathyroid hormone release in renal osteodystrophy?
Which electrolyte imbalance contributes to increased parathyroid hormone release in renal osteodystrophy?
If a patient with ESRD experiences both anemia and renal osteodystrophy, what are the two main underlying issues related to kidney function?
If a patient with ESRD experiences both anemia and renal osteodystrophy, what are the two main underlying issues related to kidney function?
The increased levels of parathyroid hormone in renal osteodystrophy directly contribute to __________ __________ .
The increased levels of parathyroid hormone in renal osteodystrophy directly contribute to __________ __________ .
What is the nature of nephron loss in chronic kidney disease?
What is the nature of nephron loss in chronic kidney disease?
Hypertension is not considered a common cause of chronic kidney disease.
Hypertension is not considered a common cause of chronic kidney disease.
What is the most common cause of chronic kidney disease?
What is the most common cause of chronic kidney disease?
__________is the most common cause of chronic kidney disease.
__________is the most common cause of chronic kidney disease.
Which of the following conditions or factors is NOT listed as a common cause of chronic kidney disease?
Which of the following conditions or factors is NOT listed as a common cause of chronic kidney disease?
Chronic kidney disease always leads to complete kidney failure within a year of diagnosis.
Chronic kidney disease always leads to complete kidney failure within a year of diagnosis.
Which of the following conditions is an inflammatory condition of the kidney and may lead to chronic kidney disease?
Which of the following conditions is an inflammatory condition of the kidney and may lead to chronic kidney disease?
Which age group is at higher risk for chronic kidney disease?
Which age group is at higher risk for chronic kidney disease?
Besides diabetes and hypertension, name one other common cause of chronic kidney disease.
Besides diabetes and hypertension, name one other common cause of chronic kidney disease.
Damage from chronic kidney disease is partially reversible with proper treatment and care.
Damage from chronic kidney disease is partially reversible with proper treatment and care.
In the prodromal phase of acute tubular necrosis, what changes are typically observed in serum BUN and creatinine levels?
In the prodromal phase of acute tubular necrosis, what changes are typically observed in serum BUN and creatinine levels?
During the oliguric phase of acute tubular necrosis, urine output typically increases significantly.
During the oliguric phase of acute tubular necrosis, urine output typically increases significantly.
What is the primary characteristic of the postoliguric phase of acute tubular necrosis regarding kidney function and urine output?
What is the primary characteristic of the postoliguric phase of acute tubular necrosis regarding kidney function and urine output?
In the oliguric phase of acute tubular necrosis, fluid retention, hyperkalemia, and __________ occur due to toxic waste buildup.
In the oliguric phase of acute tubular necrosis, fluid retention, hyperkalemia, and __________ occur due to toxic waste buildup.
Which phase of acute tubular necrosis is characterized by kidneys starting to recover, leading to increased urine output?
Which phase of acute tubular necrosis is characterized by kidneys starting to recover, leading to increased urine output?
The duration of the prodromal phase of acute tubular necrosis is independent of the severity of the initial kidney injury.
The duration of the prodromal phase of acute tubular necrosis is independent of the severity of the initial kidney injury.
What is a common clinical intervention that might be required during the oliguric phase of acute tubular necrosis?
What is a common clinical intervention that might be required during the oliguric phase of acute tubular necrosis?
During which phase of acute tubular necrosis does urine output typically drop to between 50-400 mL/day?
During which phase of acute tubular necrosis does urine output typically drop to between 50-400 mL/day?
In acute tabular necrosis, the increase in urine output during the kidneys recovery is also refered as __________ phase.
In acute tabular necrosis, the increase in urine output during the kidneys recovery is also refered as __________ phase.
Match each phase of acute tubular necrosis (ATN) with its corresponding characteristic:
Match each phase of acute tubular necrosis (ATN) with its corresponding characteristic:
Ischemia directly leads to acute tubular necrosis.
Ischemia directly leads to acute tubular necrosis.
A lack of blood supply, known as __________, can result in acute damage to kidney tubules.
A lack of blood supply, known as __________, can result in acute damage to kidney tubules.
What is the primary consequence of ischemia in the context of kidney tubules?
What is the primary consequence of ischemia in the context of kidney tubules?
Briefly explain how ischemia results in acute tubular necrosis.
Briefly explain how ischemia results in acute tubular necrosis.
Match the term with its description:
Match the term with its description:
Which condition is characterized by damage and death of tubular cells in the kidneys due to insufficient blood supply?
Which condition is characterized by damage and death of tubular cells in the kidneys due to insufficient blood supply?
Acute tubular necrosis can occur independently of ischemia.
Acute tubular necrosis can occur independently of ischemia.
If a patient's kidney tubules are found to be damaged due to a lack of oxygen, which condition likely occurred?
If a patient's kidney tubules are found to be damaged due to a lack of oxygen, which condition likely occurred?
The process of cell death from ischemia leading to acute tubular necrosis, highlights the kidney's vulnerability to _______ deprivation.
The process of cell death from ischemia leading to acute tubular necrosis, highlights the kidney's vulnerability to _______ deprivation.
Differentiate between ischemia and acute tubular necrosis.
Differentiate between ischemia and acute tubular necrosis.
Which of the following conditions is NOT typically associated with prerenal AKI?
Which of the following conditions is NOT typically associated with prerenal AKI?
Prolonged postrenal AKI can lead to acute tubular necrosis (ATN) and irreversible kidney damage.
Prolonged postrenal AKI can lead to acute tubular necrosis (ATN) and irreversible kidney damage.
__________ AKI is often caused by direct kidney damage from infections, toxins, or ischemia.
__________ AKI is often caused by direct kidney damage from infections, toxins, or ischemia.
What is the primary mechanism by which vascular injury leads to kidney damage in intrinsic/intrarenal AKI?
What is the primary mechanism by which vascular injury leads to kidney damage in intrinsic/intrarenal AKI?
Match the type of AKI with its primary cause:
Match the type of AKI with its primary cause:
List three common causes of prerenal AKI.
List three common causes of prerenal AKI.
High urine osmolality is commonly associated with postrenal AKI.
High urine osmolality is commonly associated with postrenal AKI.
Which of the following is a common cause of postrenal AKI?
Which of the following is a common cause of postrenal AKI?
In intrinsic/intrarenal AKI, __________ injury leads to inflammation, casts blocking urine flow, and backleak of filtrate.
In intrinsic/intrarenal AKI, __________ injury leads to inflammation, casts blocking urine flow, and backleak of filtrate.
What is the most common cause of Intrinsic/Intrarenal AKI?
What is the most common cause of Intrinsic/Intrarenal AKI?
Flashcards
Anemia
Anemia
Reduced number of red blood cells or hemoglobin in the blood, leading to decreased oxygen-carrying capacity.
Renal Osteodystrophy
Renal Osteodystrophy
Bone disease that occurs in patients with chronic kidney disease due to disturbances in calcium and phosphorus metabolism.
Hypertension
Hypertension
High blood pressure; a common condition where the force of the blood against artery walls is too high.
Azotemia/Uremic Syndrome
Azotemia/Uremic Syndrome
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Electrolyte Imbalance
Electrolyte Imbalance
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Metabolic Acidosis
Metabolic Acidosis
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Depression
Depression
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Potassium & Cardiac Arrest
Potassium & Cardiac Arrest
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Anemia in ESRD
Anemia in ESRD
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Uremia's effect on RBCs
Uremia's effect on RBCs
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Renal Osteodystrophy Cause
Renal Osteodystrophy Cause
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Role of PTH in Renal Osteodystrophy
Role of PTH in Renal Osteodystrophy
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Chronic Kidney Disease
Chronic Kidney Disease
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Pyelonephritis
Pyelonephritis
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Glomerulonephritis
Glomerulonephritis
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Polycystic Kidney Disease
Polycystic Kidney Disease
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Diabetes and CKD
Diabetes and CKD
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Prodromal Phase of ATN
Prodromal Phase of ATN
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Oliguric Phase of ATN
Oliguric Phase of ATN
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Postoliguric Phase of ATN
Postoliguric Phase of ATN
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Acute Tubular Necrosis (ATN)
Acute Tubular Necrosis (ATN)
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Ischemia
Ischemia
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Ischemia's Role in ATN
Ischemia's Role in ATN
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Prerenal AKI
Prerenal AKI
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Causes of Prerenal AKI
Causes of Prerenal AKI
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Postrenal AKI
Postrenal AKI
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Causes of Postrenal AKI
Causes of Postrenal AKI
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Intrinsic/Intrarenal AKI
Intrinsic/Intrarenal AKI
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Causes of Intrinsic AKI
Causes of Intrinsic AKI
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Prerenal AKI Indicators
Prerenal AKI Indicators
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Prerenal AKI consequence
Prerenal AKI consequence
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Postrenal AKI Effect
Postrenal AKI Effect
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Study Notes
- Ischemia leads to acute tubular necrosis.
Types of Acute Kidney Injury
- Prerenal AKI relating to CSlides 7-8 is caused by reduced kidney perfusion.
- Common causes of Prerenal AKI include: hypovolemia, hypotension, heart failure, renal artery obstruction, burns, dehydration, NSAIDs, and ACE inhibitors.
- Manifestations include low GFR, oliguria, and high urine osmolality.
- Prolonged prerenal injury can lead to acute tubular necrosis.
- Postrenal AKI relating to CSlide 9 is caused by obstruction of urine flow.
- Example causes include kidney stones, tumors, and an enlarged prostate.
- Backflow increases pressure in the kidneys, leading to glomerular filtration impairment.
- Prolonged postrenal AKI can lead to ATN and irreversible kidney damage.
- Intrinsic/Intrarenal AKI relating to CSlides 10-11 is caused by direct kidney damage.
- Example causes include infections, toxins, ischemia, contrast media, and sepsis.
- The most common cause is acute tubular necrosis.
- Two mechanisms of Intrinsic/Intrarenal AKI include:
- Vascular injury which causes decreased blood flow, hypoxia, and vasoconstriction.
- Tubular injury which causes inflammation, casts blocking urine flow, and backleak of filtrate.
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