Pharma- Arrhythmias Q5

1- hypotension>dizziness. 2- fatigue. 3- peripheral vasoconstriction. 4- contraindicated with asthma.

as it has some class III activity, it may be more potent> TdP risk

delay repolarisation (phase 3), extend ERF, lengthen the AP. > negative chronotropic (decrease HR), positive inotropic (increase contractility). effect on myocytes and nodal.

<p>highly lipophilic&gt;accumulation in fatty tissue. very long half life.</p> Signup and view all the answers

<p>Amiodarone.</p> Signup and view all the answers

<p>1- thyroid dysfunction 2- toxicity (liver , lungs) 3- skin discolouration 4- Tdp 5- photosensitivity</p> Signup and view all the answers

<p>Sotalol ( has class 2 and 3 activity), less effective. + Dronedarone &gt; less effective than amiodarone but (safer).</p> Signup and view all the answers

<p>block L-type Ca2+ channel. affect both nodes and myocytes. can dilate blood vessels too.</p> Signup and view all the answers

<p>decrease amplitude of AP. increases length of nodal AP (EFR), It take longer for the next AP.</p> Signup and view all the answers

<p>decrease AP length as plateau is shortened due to lower ca2+ influx &gt; risk with ventricular tachycardias. &gt; negative inotropic effect (reduced heart contraction).</p> Signup and view all the answers