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Questions and Answers
What characterizes infectious diseases?
What characterizes infectious diseases?
Which of the following is NOT considered a pathogen?
Which of the following is NOT considered a pathogen?
Which of these statements about tuberculosis is true?
Which of these statements about tuberculosis is true?
What term describes the ability of pathogens to be spread within a population!
What term describes the ability of pathogens to be spread within a population!
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Which of the following correctly explains the relationship between pathogens and diseases?
Which of the following correctly explains the relationship between pathogens and diseases?
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What is the main purpose of a vaccine?
What is the main purpose of a vaccine?
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How does vaccination lead to long-term immunity?
How does vaccination lead to long-term immunity?
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What factor necessitates the modification of vaccinations?
What factor necessitates the modification of vaccinations?
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What forms can a vaccine's antigens take?
What forms can a vaccine's antigens take?
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What is a primary reason vaccinated individuals do not usually show disease symptoms?
What is a primary reason vaccinated individuals do not usually show disease symptoms?
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What role does the blood clotting mechanism play in relation to pathogen entry?
What role does the blood clotting mechanism play in relation to pathogen entry?
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How do harmless microorganisms in the gut and skin help protect the body?
How do harmless microorganisms in the gut and skin help protect the body?
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What is the primary function of hydrochloric acid in the stomach?
What is the primary function of hydrochloric acid in the stomach?
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What effect does the enzyme lysozyme have on bacterial cells?
What effect does the enzyme lysozyme have on bacterial cells?
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What happens to pathogens when the skin is damaged?
What happens to pathogens when the skin is damaged?
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Which virus is classified as a retrovirus containing RNA?
Which virus is classified as a retrovirus containing RNA?
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What is the main type of cell that HIV infects in the human body?
What is the main type of cell that HIV infects in the human body?
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How does HIV enter helper T cells?
How does HIV enter helper T cells?
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What occurs after the viral RNA is released inside the helper T cell?
What occurs after the viral RNA is released inside the helper T cell?
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What stage follows the acute HIV syndrome stage after the initial infection?
What stage follows the acute HIV syndrome stage after the initial infection?
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What is the primary consequence of the reduction in helper T cells due to HIV infection?
What is the primary consequence of the reduction in helper T cells due to HIV infection?
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How does a mother transmit HIV to her child during birth?
How does a mother transmit HIV to her child during birth?
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At what stage is an individual classified as having advanced AIDS?
At what stage is an individual classified as having advanced AIDS?
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What is the typical cause of death for individuals with advanced AIDS?
What is the typical cause of death for individuals with advanced AIDS?
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Which of the following factors does NOT affect the progression of HIV into AIDS?
Which of the following factors does NOT affect the progression of HIV into AIDS?
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Which statement accurately distinguishes between HIV and AIDS?
Which statement accurately distinguishes between HIV and AIDS?
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How can pathogens commonly enter the body?
How can pathogens commonly enter the body?
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What role do vectors play in the transmission of pathogens?
What role do vectors play in the transmission of pathogens?
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What is a primary method of pathogen entry via ingestion?
What is a primary method of pathogen entry via ingestion?
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Which disease is commonly associated with inhalation of airborne pathogens?
Which disease is commonly associated with inhalation of airborne pathogens?
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Which method is NOT a typical route for pathogen entry into the host?
Which method is NOT a typical route for pathogen entry into the host?
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What are antigens found on?
What are antigens found on?
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What are self antigens known for?
What are self antigens known for?
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What role do antigen presenting cells play in the immune response?
What role do antigen presenting cells play in the immune response?
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What is the structure of antibodies?
What is the structure of antibodies?
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What is unique about the variable region of an antibody?
What is unique about the variable region of an antibody?
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The flexibility of an antibody molecule is primarily due to which region?
The flexibility of an antibody molecule is primarily due to which region?
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Which cells are responsible for producing antibodies?
Which cells are responsible for producing antibodies?
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Which class of antibodies has a constant region that does not vary within the class?
Which class of antibodies has a constant region that does not vary within the class?
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What triggers the specific immune response?
What triggers the specific immune response?
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Which of the following correctly describes an antigen?
Which of the following correctly describes an antigen?
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Flashcards
Disease
Disease
An illness or disorder that affects the body or mind, leading to poor health.
Signs & Symptoms
Signs & Symptoms
Specific characteristics or changes in the body that indicate a particular disease.
Infectious Diseases
Infectious Diseases
Illnesses caused by pathogens that can be spread from one person to another.
Pathogens
Pathogens
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Not All Viruses Are Pathogenic
Not All Viruses Are Pathogenic
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Helper T cells
Helper T cells
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HIV
HIV
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Reverse transcriptase
Reverse transcriptase
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Acute HIV syndrome
Acute HIV syndrome
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Asymptomatic or chronic stage
Asymptomatic or chronic stage
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Advanced AIDS
Advanced AIDS
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HIV replication
HIV replication
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Mother-to-child transmission of HIV
Mother-to-child transmission of HIV
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AIDS (Acquired Immunodeficiency Syndrome)
AIDS (Acquired Immunodeficiency Syndrome)
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HIV (Human Immunodeficiency Virus)
HIV (Human Immunodeficiency Virus)
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Opportunistic Infections
Opportunistic Infections
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Vectors
Vectors
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Route of Entry
Route of Entry
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Body Openings
Body Openings
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Breaks in the Skin
Breaks in the Skin
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Inhalation
Inhalation
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Skin as a barrier
Skin as a barrier
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Gut and Skin Flora
Gut and Skin Flora
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Stomach Acid as a Barrier
Stomach Acid as a Barrier
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Lysozyme: The Body's Antibacterial Enzyme
Lysozyme: The Body's Antibacterial Enzyme
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Blood Clotting as a Barrier
Blood Clotting as a Barrier
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What is a vaccine?
What is a vaccine?
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How do vaccines provide long-term immunity?
How do vaccines provide long-term immunity?
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What is antigen variation?
What is antigen variation?
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What is a secondary immune response?
What is a secondary immune response?
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What is passive immunity?
What is passive immunity?
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Antigens: What are they?
Antigens: What are they?
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Self Antigens: What are they?
Self Antigens: What are they?
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Non-Self Antigens: What are they?
Non-Self Antigens: What are they?
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Antigen Presenting Cells: What role do they play?
Antigen Presenting Cells: What role do they play?
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Macrophages: What makes them special?
Macrophages: What makes them special?
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Antibodies: What are they?
Antibodies: What are they?
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Antigen Binding Site: What is its role?
Antigen Binding Site: What is its role?
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Constant Region: What is it?
Constant Region: What is it?
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Variable Region: What is it?
Variable Region: What is it?
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Plasma Cells: What do they do?
Plasma Cells: What do they do?
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Hinge Region: What is it?
Hinge Region: What is it?
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Study Notes
Edexcel International A Level Biology - Immunity
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Immunity is the body's ability to fight off infections and diseases.
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Tuberculosis (TB) is a bacterial disease caused by Mycobacterium tuberculosis.
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Transmission occurs through droplets released when infected people cough or sneeze.
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The bacteria are engulfed by phagocytes, but can sometimes survive and reproduce.
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A healthy immune system can prevent TB at the primary infection stage, but it can become active later.
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HIV (Human Immunodeficiency Virus) is a retrovirus.
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Transmission occurs through bodily fluids (sexual contact, blood transfusions, sharing needles, mother-to-child).
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HIV infects helper T cells (CD4 T-lymphocytes), which are crucial for the immune response.
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The virus replicates within the helper T cell, which then burst.
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The initial stage (acute HIV syndrome) has flu-like symptoms, then a chronic stage without symptoms.
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Later (symptomatic stage), HIV symptoms arise.
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Pathogens: Routes of Entry
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Pathogens enter the body through various routes:
- Body openings (mouth, eyes, urinary tract).
- Breaks in the skin.
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Vectors are living organisms that carry pathogens and transmit them between hosts (e.g., insects like mosquitoes).
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Inhalation Exposure to pathogens through droplets released via coughs, sneezes, or talking.
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Ingestion Pathogens entering the body through contaminated food or drink.
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Indirect contact Pathogens transfer between hosts via inanimate objects like bedding or surfaces.
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Direct contact Transmission through direct skin-to-skin contact or bodily fluid exchange.
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Inoculation Pathogens enter through breaks in the skin via bites, scratches, or injections.
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Non-Specific Immune Responses
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The immune system has non-specific and specific responses.
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Non-specific responses are the body's initial reaction to any pathogen (e.g., inflammation, interferons, phagocytosis).
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Inflammation is the body's response to tissue damage to trap pathogens and stop infection.
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Interferons are proteins produced by virus-infected cells that stop viruses from spreading to other cells.
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Phagocytosis is a process where phagocytes engulf and destroy pathogens.
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Specific Immune Responses
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Antigens are molecules, proteins or glycoproteins on a cell's surface that identify 'self' and 'non-self' cells.
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Specific responses are directed against particular pathogens.
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Lymphocytes (T cells and B cells) are crucial to the specific immune response.
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T cells help to activate B cells and kill infected cells.
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B cells produce antibodies specific to antigens, and become plasma cells which release antibodies.
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Antibodies are Y-shaped proteins that bind to specific antigens on pathogens, marking them for destruction.
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Developing Immunity
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The first exposure to a pathogen (primary response) is slower as the body identifies and activates the appropriate immune responses.
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After the primary response, there are memory cells and the body retains immunity against the pathogen (secondary response) to reduce infection time and severity.
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Active immunity. Antibodies are produced by the body through exposure to antigen (natural/artificial). Memory cells are formed, resulting in long-term immunity.
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Passive immunity. Antibodies are received from another source, rather than produced by the body. No memory cells are formed, resulting in temporary immunity.
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Pathogens vs Hosts: An Evolutionary Race
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Host organisms (e.g., humans) evolve immune systems to combat pathogens.
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Pathogens evolve mechanisms to evade host immunity (e.g., antigenic variation, avoiding immune detection).
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This co-evolutionary process is considered an evolutionary arms race.
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Description
Test your knowledge on immunity, focusing on tuberculosis and HIV. This quiz covers how the immune system functions, how these pathogens spread, and the stages of infection. Ideal for students studying Edexcel International A Level Biology.