Podcast
Questions and Answers
Which of the following AEDs is a GABA analogue that binds to unknown receptors in the brain?
Which of the following AEDs is a GABA analogue that binds to unknown receptors in the brain?
- Gabapentin (correct)
- Topiramate
- Tiagabine
- Benzodiazepines
What is the primary mechanism of action of tiagabine in affecting GABA?
What is the primary mechanism of action of tiagabine in affecting GABA?
- Blocking GABA reuptake (correct)
- Potentiating GABA
- Blocking sodium channels
- Increasing GABA synthesis
Which of the following AEDs that affect GABA is also used for the treatment of neuropathic pain?
Which of the following AEDs that affect GABA is also used for the treatment of neuropathic pain?
- Tiagabine
- Gabapentin (correct)
- Benzodiazepines
- Topiramate
Which of the following AEDs that affect GABA has its absorption increased by food intake?
Which of the following AEDs that affect GABA has its absorption increased by food intake?
How is gabapentin primarily eliminated from the body?
How is gabapentin primarily eliminated from the body?
Which of the following AEDs that affect GABA has the fastest time to peak plasma concentration after oral administration?
Which of the following AEDs that affect GABA has the fastest time to peak plasma concentration after oral administration?
What is the maximum daily dosage of tiagabine in adolescents?
What is the maximum daily dosage of tiagabine in adolescents?
What is the recommended dosage increase for tiagabine in adults on enzyme-inducing AEDs?
What is the recommended dosage increase for tiagabine in adults on enzyme-inducing AEDs?
What is the maximum daily dose of tiagabine for adults on enzyme-inducing AEDs?
What is the maximum daily dose of tiagabine for adults on enzyme-inducing AEDs?
What should a patient do if they miss a dose of tiagabine?
What should a patient do if they miss a dose of tiagabine?
What monitoring is required for patients taking topiramate?
What monitoring is required for patients taking topiramate?
What is the most common adverse reaction associated with perampanel?
What is the most common adverse reaction associated with perampanel?
What is the primary route of excretion for perampanel?
What is the primary route of excretion for perampanel?
What is the half-life of perampanel?
What is the half-life of perampanel?
Which of the following is a true statement about the pharmacokinetics of perampanel?
Which of the following is a true statement about the pharmacokinetics of perampanel?
What is the recommended approach if a patient has missed multiple doses of tiagabine?
What is the recommended approach if a patient has missed multiple doses of tiagabine?
What is a potential effect of topiramate use on infants who ingest the drug through breast milk?
What is a potential effect of topiramate use on infants who ingest the drug through breast milk?
Which adverse effect is more prevalent in patients taking topiramate compared to the control group?
Which adverse effect is more prevalent in patients taking topiramate compared to the control group?
Why is it advised not to abruptly discontinue topiramate?
Why is it advised not to abruptly discontinue topiramate?
Which category is assigned to tiagabine in terms of pregnancy risk?
Which category is assigned to tiagabine in terms of pregnancy risk?
What is the most common central nervous system (CNS) adverse effect of gabapentin?
What is the most common central nervous system (CNS) adverse effect of gabapentin?
In children, what is one of the neuropsychiatric adverse effects of gabapentin?
In children, what is one of the neuropsychiatric adverse effects of gabapentin?
What is a common side effect reported in patients taking tiagabine concomitantly with other medications?
What is a common side effect reported in patients taking tiagabine concomitantly with other medications?
Which group of patients should exercise caution when prescribed drugs that predispose to heat-related disorders?
Which group of patients should exercise caution when prescribed drugs that predispose to heat-related disorders?
What is the effect of abrupt tiagabine discontinuation?
What is the effect of abrupt tiagabine discontinuation?
Which factor should be monitored in infants exposed to tiagabine through breast milk?
Which factor should be monitored in infants exposed to tiagabine through breast milk?
What neuropsychiatric symptoms have been reported in patients taking perampanel?
What neuropsychiatric symptoms have been reported in patients taking perampanel?
What is a boxed warning for perampanel that clinicians should monitor for?
What is a boxed warning for perampanel that clinicians should monitor for?
Which adverse drug reaction (ADR) is commonly associated with perampanel?
Which adverse drug reaction (ADR) is commonly associated with perampanel?
What is a potential drug interaction with perampanel that can decrease its levels?
What is a potential drug interaction with perampanel that can decrease its levels?
In patients taking enzyme-inducing AEDs, what is the recommended initial dose of perampanel?
In patients taking enzyme-inducing AEDs, what is the recommended initial dose of perampanel?
In patients with mild hepatic impairment, what is the maximum recommended daily dose of perampanel?
In patients with mild hepatic impairment, what is the maximum recommended daily dose of perampanel?
What is the age range for which perampanel is approved for use?
What is the age range for which perampanel is approved for use?
What is the most common adverse drug reaction (ADR) reported in patients taking levetiracetam?
What is the most common adverse drug reaction (ADR) reported in patients taking levetiracetam?
Which of the following is an uncommon but significant behavioral change associated with levetiracetam use?
Which of the following is an uncommon but significant behavioral change associated with levetiracetam use?
What age group is the extended-release formula of levetiracetam (Keppra XR) FDA approved for?
What age group is the extended-release formula of levetiracetam (Keppra XR) FDA approved for?
Which enzyme does levetiracetam not use for metabolism, reducing the likelihood of drug interactions?
Which enzyme does levetiracetam not use for metabolism, reducing the likelihood of drug interactions?
In clinical trials of 11 antiepileptic drugs (AEDs), what was the risk of suicidal thoughts or behavior in patients randomized to one of the AEDs compared to controls?
In clinical trials of 11 antiepileptic drugs (AEDs), what was the risk of suicidal thoughts or behavior in patients randomized to one of the AEDs compared to controls?
Which medication is indicated for primary generalized tonic-clonic seizures in adults and children aged 6 years or older?
Which medication is indicated for primary generalized tonic-clonic seizures in adults and children aged 6 years or older?
What adverse event may occur if levetiracetam is abruptly discontinued?
What adverse event may occur if levetiracetam is abruptly discontinued?
Which medication does not interact with levetiracetam, as mentioned in the text?
Which medication does not interact with levetiracetam, as mentioned in the text?
What type of seizures is levetiracetam indicated for in adolescents aged 12 or older with juvenile myoclonic epilepsy?
What type of seizures is levetiracetam indicated for in adolescents aged 12 or older with juvenile myoclonic epilepsy?
Which of the following symptoms should patients be warned about when starting on levetiracetam?
Which of the following symptoms should patients be warned about when starting on levetiracetam?
What is the primary route of elimination for topiramate in the body?
What is the primary route of elimination for topiramate in the body?
What enzyme is primarily responsible for metabolizing tiagabine in the liver?
What enzyme is primarily responsible for metabolizing tiagabine in the liver?
Which age group has the shortest half-life for tiagabine?
Which age group has the shortest half-life for tiagabine?
What should be monitored in patients taking gabapentin due to the increased risk associated with this class of drugs?
What should be monitored in patients taking gabapentin due to the increased risk associated with this class of drugs?
What is a contraindication for using gabapentin?
What is a contraindication for using gabapentin?
Which tricyclic antidepressant has the shortest half-life?
Which tricyclic antidepressant has the shortest half-life?
What potential adverse effect is associated with topiramate therapy in pediatric patients?
What potential adverse effect is associated with topiramate therapy in pediatric patients?
What is the main reason gabapentin should not be abruptly discontinued?
What is the main reason gabapentin should not be abruptly discontinued?
Severe metabolic acidosis has been reported in infants receiving what dose of topiramate per day?
Severe metabolic acidosis has been reported in infants receiving what dose of topiramate per day?
What pharmacotherapeutic precaution is advised for patients taking gabapentin regarding suicidal behavior?
What pharmacotherapeutic precaution is advised for patients taking gabapentin regarding suicidal behavior?
What adverse reaction is commonly associated with topiramate use?
What adverse reaction is commonly associated with topiramate use?
Which CNS-related adverse reactions are commonly reported with tiagabine use?
Which CNS-related adverse reactions are commonly reported with tiagabine use?
What effect may gabapentin have in combination with alcohol?
What effect may gabapentin have in combination with alcohol?
In pediatric patients aged 3 to 12 years, what is the usual starting dose of gabapentin for seizures?
In pediatric patients aged 3 to 12 years, what is the usual starting dose of gabapentin for seizures?
What is the recommended total daily dose of topiramate for patients with partial-onset seizures?
What is the recommended total daily dose of topiramate for patients with partial-onset seizures?
What is the recommended initial dose of topiramate for epilepsy in adolescents aged 12 to 18 years?
What is the recommended initial dose of topiramate for epilepsy in adolescents aged 12 to 18 years?
What is the usual maintenance dose of topiramate in children with epilepsy?
What is the usual maintenance dose of topiramate in children with epilepsy?
How should tiagabine dosing be adjusted if an enzyme-inducing drug is added?
How should tiagabine dosing be adjusted if an enzyme-inducing drug is added?
What renal function consideration is important for gabapentin dosing?
What renal function consideration is important for gabapentin dosing?
Which statement about levetiracetam's mechanism of action is correct?
Which statement about levetiracetam's mechanism of action is correct?
What is the primary route of elimination for levetiracetam?
What is the primary route of elimination for levetiracetam?
Which of the following is a potential adverse effect of levetiracetam?
Which of the following is a potential adverse effect of levetiracetam?
What is the recommended approach if a patient needs to discontinue levetiracetam?
What is the recommended approach if a patient needs to discontinue levetiracetam?
Which statement about levetiracetam's pharmacokinetics is correct?
Which statement about levetiracetam's pharmacokinetics is correct?
Which of the following is a precaution or contraindication for levetiracetam use?
Which of the following is a precaution or contraindication for levetiracetam use?
Which statement about levetiracetam's use in pregnancy is correct?
Which statement about levetiracetam's use in pregnancy is correct?
Which of the following is a potential adverse effect of levetiracetam on blood cell counts?
Which of the following is a potential adverse effect of levetiracetam on blood cell counts?
For which age groups is levetiracetam FDA approved for use as adjunctive therapy in partial-onset seizures?
For which age groups is levetiracetam FDA approved for use as adjunctive therapy in partial-onset seizures?
What is the recommended precaution for patients starting levetiracetam therapy?
What is the recommended precaution for patients starting levetiracetam therapy?
