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GABA and Seizures

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Questions and Answers

True or false: A seizure occurs due to an increase in inhibitory activity in the brain?

False

True or false: GABA is the most important excitatory neurotransmitter in the brain?

False

True or false: Benzodiazepines bind to multiple receptor sites on GABA-A receptors?

True

True or false: Lorazepam and diazepam are commonly used for long-term treatment of epilepsy?

False Signup and view all the answers

True or false: Phenobarbital is one of the barbiturates commonly used in the treatment of epilepsy?

True Signup and view all the answers

What is the most important inhibitory neurotransmitter in the brain?

Gamma-aminobutyric acid (GABA) Signup and view all the answers

What are the three substances that have multiple binding sites on GABA-A receptors?

Benzodiazepines, barbiturates, and other substances (eg, picrotoxins, bicuculline, and neurosteroids) Signup and view all the answers

Which benzodiazepines are commonly used for the emergency treatment of seizures?

Lorazepam and diazepam Signup and view all the answers

Why are lorazepam and diazepam not commonly used for long-term treatment of epilepsy?

Because of the development of tolerance Signup and view all the answers

What are the two barbiturates commonly used in the treatment of epilepsy?

Phenobarbital and clobazam Signup and view all the answers