GABA and Seizures

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Questions and Answers

True or false: A seizure occurs due to an increase in inhibitory activity in the brain?

False (B)

True or false: GABA is the most important excitatory neurotransmitter in the brain?

False (B)

True or false: Benzodiazepines bind to multiple receptor sites on GABA-A receptors?

True (A)

True or false: Lorazepam and diazepam are commonly used for long-term treatment of epilepsy?

<p>False (B)</p> Signup and view all the answers

True or false: Phenobarbital is one of the barbiturates commonly used in the treatment of epilepsy?

<p>True (A)</p> Signup and view all the answers

What is the most important inhibitory neurotransmitter in the brain?

<p>Gamma-aminobutyric acid (GABA)</p> Signup and view all the answers

What are the three substances that have multiple binding sites on GABA-A receptors?

<p>Benzodiazepines, barbiturates, and other substances (eg, picrotoxins, bicuculline, and neurosteroids)</p> Signup and view all the answers

Which benzodiazepines are commonly used for the emergency treatment of seizures?

<p>Lorazepam and diazepam</p> Signup and view all the answers

Why are lorazepam and diazepam not commonly used for long-term treatment of epilepsy?

<p>Because of the development of tolerance</p> Signup and view all the answers

What are the two barbiturates commonly used in the treatment of epilepsy?

<p>Phenobarbital and clobazam</p> Signup and view all the answers

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