Drug Therapy in Pediatric & Geriatric Age Groups
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Questions and Answers

What is the Young's formula used for in pediatric drug dosage calculations?

  • To calculate the dose based on weight and age in kilograms
  • To calculate the dose based on age in years (correct)
  • To calculate the dose based on adult dose and age in years
  • To calculate the dose based on body weight in kilograms
  • What is Clark's rule used for in pediatric drug dosage calculations?

  • To calculate the dose based on body weight in kilograms (correct)
  • To calculate the dose based on age in years
  • To calculate the dose based on weight and age in kilograms
  • To calculate the dose based on adult dose and age in years
  • Why do augmented responses to warfarin occur in prepubertal patients at similar plasma concentrations as in adults?

  • Due to differences in pediatric and adult drug approval processes
  • Due to differences in the drug's mechanism of action
  • Due to immature receptors or neurotransmitter systems (correct)
  • Due to a pharmacodynamic mechanism
  • Why do most drugs approved for use in children have recommended pediatric doses stated as milligrams per kilogram?

    <p>To adjust for differences in body weight among children</p> Signup and view all the answers

    Why is intravenous (IV) route preferred in serious conditions for pediatric patients?

    <p>It bypasses the slower gastrointestinal absorption seen in infancy.</p> Signup and view all the answers

    What is a common characteristic of adverse effects of drugs in children compared to adults?

    <p>They are generally similar to those in adults</p> Signup and view all the answers

    Why is rectal administration considered adequate for certain drugs in pediatric patients?

    <p>It can achieve adequate absorption for drugs like diazepam and theophylline.</p> Signup and view all the answers

    Why do pediatric patients require lower drug doses when administered through intact skin?

    <p>To prevent systemic toxicity from excessive absorption.</p> Signup and view all the answers

    How does gastrointestinal absorption compare between infants and adults?

    <p>It is slower in infants compared to adults.</p> Signup and view all the answers

    Why is plasma protein binding of drugs reduced in neonates?

    <p>Because of immature binding proteins in neonates.</p> Signup and view all the answers

    What effect does the thin infant skin have on drug absorption via the percutaneous route?

    <p>It accelerates drug penetration and can cause systemic toxicity.</p> Signup and view all the answers

    What is the rationale behind using oral preparations that taste pleasant for children under the age of five years?

    <p>To improve compliance since children may have difficulty swallowing tablets</p> Signup and view all the answers

    Which route of administration is particularly valuable in the treatment of status epilepticus in children?

    <p>Rectal administration</p> Signup and view all the answers

    Why are nebulizers preferred over pressurized aerosols for children under the age of ten years?

    <p>Pressurized aerosols require coordinated deep inspiration</p> Signup and view all the answers

    Why should rectal administration be considered if a child is vomiting?

    <p>It ensures drug delivery even if the child is vomiting</p> Signup and view all the answers

    How should doses for prescribed drugs be calculated for pediatric populations?

    <p>Based on the child's weight</p> Signup and view all the answers

    What is the purpose of ensuring proper instructions to the caregiver when prescribing drugs for children?

    <p>To improve compliance and medication administration accuracy</p> Signup and view all the answers

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