Drug Permeation through Cell Membrane and Blood-Brain Barrier
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Questions and Answers

What type of materials can enter cells through the lipid membrane?

  • Polar materials
  • Non-polar materials (correct)
  • Highly hydrophilic materials
  • Large molecular weight materials

    • Which type of substances can easily cross renal tubules?

  • Non-polar and non-ionized compounds (correct)
  • Highly hydrophilic compounds
  • Polar and ionized compounds
  • Lipid and ionized compounds

    • What is the quantitative measure of how much of a substance can dissolve in lipids?

  • Concentration gradient
  • Log P value
  • Lipophilicity (correct)
  • Degree of ionization

    • Which factor facilitates the easy crossing of non-ionized drugs across cell membranes?

    <p>Concentration gradient</p> Signup and view all the answers

    What does 'log P' represent in pharmacokinetics?

    <p>Lipid-aqueous partitioning of drugs</p> Signup and view all the answers

    Which type of transporter relies on an energy source?

    <p>Solute carrier transporter</p> Signup and view all the answers

    What is the primary energy source for active transport?

    <p>ATP</p> Signup and view all the answers

    Which region in the gastrointestinal tract is considered acidic for drug absorption?

    <p>Duodenum</p> Signup and view all the answers

    What physicochemical property affects the absorption rate of a drug?

    <p>Log P value</p> Signup and view all the answers

    Which type of drugs are poorly absorbed due to their high polarity?

    <p>Gentamicin</p> Signup and view all the answers

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