Drug Permeation through Cell Membrane and Blood-Brain Barrier

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Questions and Answers

What type of materials can enter cells through the lipid membrane?

  • Polar materials
  • Non-polar materials (correct)
  • Highly hydrophilic materials
  • Large molecular weight materials

Which type of substances can easily cross renal tubules?

  • Non-polar and non-ionized compounds (correct)
  • Highly hydrophilic compounds
  • Polar and ionized compounds
  • Lipid and ionized compounds

What is the quantitative measure of how much of a substance can dissolve in lipids?

  • Concentration gradient
  • Log P value
  • Lipophilicity (correct)
  • Degree of ionization

Which factor facilitates the easy crossing of non-ionized drugs across cell membranes?

<p>Concentration gradient (B)</p> Signup and view all the answers

What does 'log P' represent in pharmacokinetics?

<p>Lipid-aqueous partitioning of drugs (C)</p> Signup and view all the answers

Which type of transporter relies on an energy source?

<p>Solute carrier transporter (C)</p> Signup and view all the answers

What is the primary energy source for active transport?

<p>ATP (B)</p> Signup and view all the answers

Which region in the gastrointestinal tract is considered acidic for drug absorption?

<p>Duodenum (B)</p> Signup and view all the answers

What physicochemical property affects the absorption rate of a drug?

<p>Log P value (D)</p> Signup and view all the answers

Which type of drugs are poorly absorbed due to their high polarity?

<p>Gentamicin (D)</p> Signup and view all the answers

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