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Questions and Answers
What is the term for the phenomenon where a drug is conjugated either rapidly or slowly with acetyl-CoA in the human population?
What is the term for the phenomenon where a drug is conjugated either rapidly or slowly with acetyl-CoA in the human population?
- Acetylation bimodality
- Acetylation dichotomy
- Acetylation polymorphism (correct)
- Acetylation variation
Which populations are classified as slow acetylators based on differences in N-acetyltransferase activity?
Which populations are classified as slow acetylators based on differences in N-acetyltransferase activity?
- Eskimos and Asians
- Inuit and Africans
- Egyptians and some Western European groups (correct)
- Latin Americans and Indians
Which of the following is NOT true about slow acetylators?
Which of the following is NOT true about slow acetylators?
- Conjugate drugs with acetyl-CoA rapidly (correct)
- Show an inadequate therapeutic response to standard drug doses
- Display a bimodal distribution in the human population
- More prone to developing adverse reactions
What is the main cause of acetylation polymorphism in individuals?
What is the main cause of acetylation polymorphism in individuals?
Which of the following drugs exemplifies acetylation polymorphism?
Which of the following drugs exemplifies acetylation polymorphism?
What is the objective of methylation in the metabolic pathway?
What is the objective of methylation in the metabolic pathway?
What type of metabolites does methylation generally not lead to?
What type of metabolites does methylation generally not lead to?
Which activated coenzyme is involved in methylation reactions?
Which activated coenzyme is involved in methylation reactions?
Which enzyme carries out O-methylation of important neurotransmitters like norepinephrine and dopamine?
Which enzyme carries out O-methylation of important neurotransmitters like norepinephrine and dopamine?
Which type of methylation do transferases specifically methylating histamine, serotonin, and epinephrine not usually participate in?
Which type of methylation do transferases specifically methylating histamine, serotonin, and epinephrine not usually participate in?
What feature does COMT require for carrying out methylation reactions?
What feature does COMT require for carrying out methylation reactions?
Which phase pathways are drugs and xenobiotics often metabolized by to give several metabolites?
Which phase pathways are drugs and xenobiotics often metabolized by to give several metabolites?
Which enzyme is primarily involved in methylation reactions in the body?
Which enzyme is primarily involved in methylation reactions in the body?
Which type of drug derivative undergoes methylation reactions to form methylated products?
Which type of drug derivative undergoes methylation reactions to form methylated products?
Which biological factor can affect the activity of methyltransferases and consequently alter drug metabolism?
Which biological factor can affect the activity of methyltransferases and consequently alter drug metabolism?
Which factor determines the stereoselectivity of substrates in methylation reactions?
Which factor determines the stereoselectivity of substrates in methylation reactions?
Which factor can lead to the accumulation of toxic levels of a drug due to decreased metabolic elimination?
Which factor can lead to the accumulation of toxic levels of a drug due to decreased metabolic elimination?
Which factor can decrease the intensity and duration of drug action as well as its efficacy?
Which factor can decrease the intensity and duration of drug action as well as its efficacy?
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