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Questions and Answers
Which enzyme is responsible for the O-methylation of important neurotransmitters such as norepinephrine and dopamine?
Which enzyme is responsible for the O-methylation of important neurotransmitters such as norepinephrine and dopamine?
- Catechol-O-methyltransferase (COMT) (correct)
- Epinephrine-O-methyltransferase
- Histamine-O-methyltransferase
- Serotonin-O-methyltransferase
Which of the following is the activated coenzyme involved in methylation reactions?
Which of the following is the activated coenzyme involved in methylation reactions?
- S-adenosylcysteine (SAC)
- S-adenosylmethionine (SAM) (correct)
- S-adenosylglutathione (SAG)
- S-adenosylhomocysteine (SAH)
Which type of methylation reaction does not create a quaternary ammonium derivative and thus tends to result in pharmacologically inactive compounds?
Which type of methylation reaction does not create a quaternary ammonium derivative and thus tends to result in pharmacologically inactive compounds?
- N-methylation
- C-methylation
- O-methylation (correct)
- S-methylation
Which of the following methyltransferases is NOT typically involved in the metabolism of xenobiotics?
Which of the following methyltransferases is NOT typically involved in the metabolism of xenobiotics?
Which of the following is NOT an example of a phase II reaction involving a conjugation process?
Which of the following is NOT an example of a phase II reaction involving a conjugation process?
Which of the following factors affects the metabolism of drugs and xenobiotics the most?
Which of the following factors affects the metabolism of drugs and xenobiotics the most?
Which metabolic pathway is primarily responsible for terminating the biological activity of biogenic amines?
Which metabolic pathway is primarily responsible for terminating the biological activity of biogenic amines?
Which of the following drugs exhibits acetylation polymorphism resulting in variable therapeutic and toxicological responses?
Which of the following drugs exhibits acetylation polymorphism resulting in variable therapeutic and toxicological responses?
Which of the following populations is typically categorized as slow acetylators?
Which of the following populations is typically categorized as slow acetylators?
Which phase II reaction is least likely to be involved in the metabolism of drugs and xenobiotics?
Which phase II reaction is least likely to be involved in the metabolism of drugs and xenobiotics?
Which of the following biogenic amines is not primarily metabolized via methylation?
Which of the following biogenic amines is not primarily metabolized via methylation?
Which of the following statements about acetylation polymorphism is true?
Which of the following statements about acetylation polymorphism is true?
What is the primary determinant of the relative amount of a particular metabolite?
What is the primary determinant of the relative amount of a particular metabolite?
What is the consequence of a decreased rate of metabolism of a drug?
What is the consequence of a decreased rate of metabolism of a drug?
What is a factor that can affect drug metabolism and is influenced by the drug's chemical structure?
What is a factor that can affect drug metabolism and is influenced by the drug's chemical structure?
What type of stereoselectivity refers to the preferential interaction of one stereoisomer with metabolizing enzymes at a specific region of the molecule?
What type of stereoselectivity refers to the preferential interaction of one stereoisomer with metabolizing enzymes at a specific region of the molecule?
What is the consequence of an increased rate of metabolism of a drug?
What is the consequence of an increased rate of metabolism of a drug?
What is an example of a biological factor that can affect drug metabolism?
What is an example of a biological factor that can affect drug metabolism?
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