Podcast
Questions and Answers
What is the term used to describe the bimodal acetylation pattern of drugs like isoniazid in the human population?
What is the term used to describe the bimodal acetylation pattern of drugs like isoniazid in the human population?
- Acetylation modulation
- Acetylation variation
- Acetylation biogenesis
- Acetylation polymorphism (correct)
Which enzyme activity mainly causes the genetic variation leading to differences in acetylation patterns among individuals?
Which enzyme activity mainly causes the genetic variation leading to differences in acetylation patterns among individuals?
- N-acetyltransferase activity (correct)
- Monoamine oxidase activity
- Methyltransferase activity
- Sulfotransferase activity
Individuals classified as rapid acetylators are more likely to exhibit which of the following responses to drugs?
Individuals classified as rapid acetylators are more likely to exhibit which of the following responses to drugs?
- Developing allergic reactions
- Experiencing adverse reactions
- Showing inadequate therapeutic responses (correct)
- Having optimal drug efficacy
In methylation, what is the primary source of the methyl group used in the metabolic reactions?
In methylation, what is the primary source of the methyl group used in the metabolic reactions?
Which biological activity does methylation aim to terminate by acting on biogenic amines like norepinephrine and histamine?
Which biological activity does methylation aim to terminate by acting on biogenic amines like norepinephrine and histamine?
In methylation, what is the primary purpose of the metabolic pathway with respect to endogenous compounds?
In methylation, what is the primary purpose of the metabolic pathway with respect to endogenous compounds?
Which enzyme is often involved in methylation reactions?
Which enzyme is often involved in methylation reactions?
What is the role of S-adenosylmethionine (SAM) in metabolism?
What is the role of S-adenosylmethionine (SAM) in metabolism?
Which type of metabolites can be formed from methylation reactions?
Which type of metabolites can be formed from methylation reactions?
Quaternary ammonium derivatives are often used for which purpose?
Quaternary ammonium derivatives are often used for which purpose?
Which of these factors can affect the rate of drug metabolism?
Which of these factors can affect the rate of drug metabolism?
What is stereoselectivity in drug metabolism?
What is stereoselectivity in drug metabolism?
Which compound is created when methylation leads to a polar or water-soluble metabolite?
Which compound is created when methylation leads to a polar or water-soluble metabolite?
Which enzyme catalyzes methylation reactions using S-adenosylmethionine (SAM)?
Which enzyme catalyzes methylation reactions using S-adenosylmethionine (SAM)?
Which enzyme is responsible for terminating the activity of neurotransmitters such as norepinephrine and dopamine through O-methylation?
Which enzyme is responsible for terminating the activity of neurotransmitters such as norepinephrine and dopamine through O-methylation?
Which coenzyme is involved in the methylation of histamine, serotonin, and epinephrine by specific transferases?
Which coenzyme is involved in the methylation of histamine, serotonin, and epinephrine by specific transferases?
Which drugs undergo significant O-methylation, N-methylation, and S-methylation by various Methyltransferases?
Which drugs undergo significant O-methylation, N-methylation, and S-methylation by various Methyltransferases?
What is the functional group required for the enzyme COMT to carry out methylation in the above-mentioned drugs?
What is the functional group required for the enzyme COMT to carry out methylation in the above-mentioned drugs?
Flashcards are hidden until you start studying
