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Questions and Answers
What are common adverse effects of levetiracetam?
What are contraindications for levetiracetam?
How is topiramate primarily eliminated from the body?
What is a potential mechanism of action of topiramate?
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What should be done for patients with CrCl less than 70 mL/min when using topiramate?
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What are adverse effects of topiramate?
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What is a potential risk associated with postmarketing research of levetiracetam?
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What is a contraindication for levetiracetam use?
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What type of medications combined with levetiracetam may increase sedation symptoms?
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What should be done with IV preparation of levetiracetam?
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What is a potential interaction of topiramate?
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At what temperature should topiramate be stored?
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What is the approved use of levetiracetam in treating seizure disorders?
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How is levetiracetam primarily eliminated from the body?
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What is the mechanism of action of levetiracetam?
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What is the recommended action for patients with impaired renal function when using levetiracetam?
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What is the approved use of levetiracetam in treating seizure disorders?
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How is levetiracetam primarily eliminated from the body?
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What is the mechanism of action of levetiracetam?
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What is the protein binding percentage of levetiracetam?
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Study Notes
Antiepileptic Medications: Levetiracetam and Topiramate
- Neonate's CrCl and weight affect pharmacokinetic properties of levetiracetam
- Common adverse effects of levetiracetam include drowsiness, dizziness, decreases in blood cell counts, double vision, and anxiety
- Postmarketing research notes risk of hepatic failure, acute renal failure, multiorgan failure, and Stevens-Johnson syndrome with levetiracetam
- Contraindications for levetiracetam include hypersensitivity, pregnancy, lactation, and suicidal ideation
- CNS depressants combined with levetiracetam may increase sedation symptoms
- IV preparation of levetiracetam should be administered on a short-term basis only
- Topiramate is absorbed in the GI tract, has a half-life of about 21 hours, and is primarily eliminated via the kidneys
- Mechanism of action of topiramate is not fully understood, but it may involve blockage of sodium channels and increased GABA activity
- Topiramate is used as monotherapy or adjunctive therapy for seizures and as a preventive for migraine headaches
- Patients with CrCl less than 70 mL/min should receive reduced doses of topiramate
- Adverse effects of topiramate include CNS effects, GI adverse effects, metabolic adverse effects, renal stones, increased intraocular pressure, and oligohydrosis
- Topiramate interacts with oral contraceptives and Ginkgo biloba, has a bitter taste, and should be stored at 59°F to 86°F
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Description
Test your knowledge of antiepileptic medications with a focus on levetiracetam and topiramate. Explore their pharmacokinetic properties, adverse effects, contraindications, and interactions with other medications.
