Antiepileptic Medications Quiz

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Questions and Answers

What are common adverse effects of levetiracetam?

Drowsiness, dizziness, decreases in blood cell counts, double vision, and anxiety (correct)

Nausea, vomiting, diarrhea, headache, and insomnia

Constipation, dry mouth, blurred vision, and weight gain

Rash, fever, joint pain, muscle aches, and confusion

What are contraindications for levetiracetam?

Anemia, liver disease, kidney disease, and glaucoma

Hypertension, diabetes, hyperlipidemia, and asthma

Alcoholism, depression, anxiety, and insomnia

Hypersensitivity, pregnancy, lactation, and suicidal ideation (correct)

How is topiramate primarily eliminated from the body?

Through the lungs

Through the skin

Via the kidneys (correct)

Via the liver

What is a potential mechanism of action of topiramate?

Blockage of sodium channels and increased GABA activity Signup and view all the answers

What should be done for patients with CrCl less than 70 mL/min when using topiramate?

Receive reduced doses of topiramate Signup and view all the answers

What are adverse effects of topiramate?

CNS effects, GI adverse effects, metabolic adverse effects, renal stones, increased intraocular pressure, and oligohydrosis Signup and view all the answers

What is a potential risk associated with postmarketing research of levetiracetam?

Hepatic failure, acute renal failure, multiorgan failure, and Stevens-Johnson syndrome Signup and view all the answers

What is a contraindication for levetiracetam use?

Pregnancy Signup and view all the answers

What type of medications combined with levetiracetam may increase sedation symptoms?

CNS depressants Signup and view all the answers

What should be done with IV preparation of levetiracetam?

Administered on a short-term basis only Signup and view all the answers

What is a potential interaction of topiramate?

Oral contraceptives and Ginkgo biloba Signup and view all the answers

At what temperature should topiramate be stored?

59°F to 86°F Signup and view all the answers

What is the approved use of levetiracetam in treating seizure disorders?

Myoclonic, tonic–clonic, and partial seizures Signup and view all the answers

How is levetiracetam primarily eliminated from the body?

Renal excretion Signup and view all the answers

What is the mechanism of action of levetiracetam?

Inhibits abnormal neuronal firing without affecting normal neuronal excitability Signup and view all the answers

What is the recommended action for patients with impaired renal function when using levetiracetam?

Reduce the dose Signup and view all the answers

What is the approved use of levetiracetam in treating seizure disorders?

Partial-onset and generalized tonic–clonic seizures Signup and view all the answers

How is levetiracetam primarily eliminated from the body?

Urine Signup and view all the answers

What is the mechanism of action of levetiracetam?

Unknown Signup and view all the answers

What is the protein binding percentage of levetiracetam?

10% Signup and view all the answers

Study Notes

Antiepileptic Medications: Levetiracetam and Topiramate

Neonate's CrCl and weight affect pharmacokinetic properties of levetiracetam
Common adverse effects of levetiracetam include drowsiness, dizziness, decreases in blood cell counts, double vision, and anxiety
Postmarketing research notes risk of hepatic failure, acute renal failure, multiorgan failure, and Stevens-Johnson syndrome with levetiracetam
Contraindications for levetiracetam include hypersensitivity, pregnancy, lactation, and suicidal ideation
CNS depressants combined with levetiracetam may increase sedation symptoms
IV preparation of levetiracetam should be administered on a short-term basis only
Topiramate is absorbed in the GI tract, has a half-life of about 21 hours, and is primarily eliminated via the kidneys
Mechanism of action of topiramate is not fully understood, but it may involve blockage of sodium channels and increased GABA activity
Topiramate is used as monotherapy or adjunctive therapy for seizures and as a preventive for migraine headaches
Patients with CrCl less than 70 mL/min should receive reduced doses of topiramate
Adverse effects of topiramate include CNS effects, GI adverse effects, metabolic adverse effects, renal stones, increased intraocular pressure, and oligohydrosis
Topiramate interacts with oral contraceptives and Ginkgo biloba, has a bitter taste, and should be stored at 59°F to 86°F

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Description

Test your knowledge of antiepileptic medications with a focus on levetiracetam and topiramate. Explore their pharmacokinetic properties, adverse effects, contraindications, and interactions with other medications.