Podcast
Questions and Answers
What are common adverse effects of levetiracetam?
What are common adverse effects of levetiracetam?
What are contraindications for levetiracetam?
What are contraindications for levetiracetam?
How is topiramate primarily eliminated from the body?
How is topiramate primarily eliminated from the body?
What is a potential mechanism of action of topiramate?
What is a potential mechanism of action of topiramate?
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What should be done for patients with CrCl less than 70 mL/min when using topiramate?
What should be done for patients with CrCl less than 70 mL/min when using topiramate?
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What are adverse effects of topiramate?
What are adverse effects of topiramate?
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What is a potential risk associated with postmarketing research of levetiracetam?
What is a potential risk associated with postmarketing research of levetiracetam?
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What is a contraindication for levetiracetam use?
What is a contraindication for levetiracetam use?
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What type of medications combined with levetiracetam may increase sedation symptoms?
What type of medications combined with levetiracetam may increase sedation symptoms?
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What should be done with IV preparation of levetiracetam?
What should be done with IV preparation of levetiracetam?
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What is a potential interaction of topiramate?
What is a potential interaction of topiramate?
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At what temperature should topiramate be stored?
At what temperature should topiramate be stored?
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What is the approved use of levetiracetam in treating seizure disorders?
What is the approved use of levetiracetam in treating seizure disorders?
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How is levetiracetam primarily eliminated from the body?
How is levetiracetam primarily eliminated from the body?
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What is the mechanism of action of levetiracetam?
What is the mechanism of action of levetiracetam?
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What is the recommended action for patients with impaired renal function when using levetiracetam?
What is the recommended action for patients with impaired renal function when using levetiracetam?
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What is the approved use of levetiracetam in treating seizure disorders?
What is the approved use of levetiracetam in treating seizure disorders?
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How is levetiracetam primarily eliminated from the body?
How is levetiracetam primarily eliminated from the body?
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What is the mechanism of action of levetiracetam?
What is the mechanism of action of levetiracetam?
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What is the protein binding percentage of levetiracetam?
What is the protein binding percentage of levetiracetam?
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Study Notes
Antiepileptic Medications: Levetiracetam and Topiramate
- Neonate's CrCl and weight affect pharmacokinetic properties of levetiracetam
- Common adverse effects of levetiracetam include drowsiness, dizziness, decreases in blood cell counts, double vision, and anxiety
- Postmarketing research notes risk of hepatic failure, acute renal failure, multiorgan failure, and Stevens-Johnson syndrome with levetiracetam
- Contraindications for levetiracetam include hypersensitivity, pregnancy, lactation, and suicidal ideation
- CNS depressants combined with levetiracetam may increase sedation symptoms
- IV preparation of levetiracetam should be administered on a short-term basis only
- Topiramate is absorbed in the GI tract, has a half-life of about 21 hours, and is primarily eliminated via the kidneys
- Mechanism of action of topiramate is not fully understood, but it may involve blockage of sodium channels and increased GABA activity
- Topiramate is used as monotherapy or adjunctive therapy for seizures and as a preventive for migraine headaches
- Patients with CrCl less than 70 mL/min should receive reduced doses of topiramate
- Adverse effects of topiramate include CNS effects, GI adverse effects, metabolic adverse effects, renal stones, increased intraocular pressure, and oligohydrosis
- Topiramate interacts with oral contraceptives and Ginkgo biloba, has a bitter taste, and should be stored at 59°F to 86°F
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Description
Test your knowledge of antiepileptic medications with a focus on levetiracetam and topiramate. Explore their pharmacokinetic properties, adverse effects, contraindications, and interactions with other medications.
