Drug-Drug Interactions and Absorption Effects Quiz

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What is the most likely explanation for side effects or adverse effects of a drug?

Toxic effects due to excessive dosage

Which factor contributes to the slower gastric emptying in pediatrics?

Less acidic gastric pH

What is the term used to describe a physiologic or psychological need for a drug?

Dependence

In pharmacogenetics/genomics, what contributes to the variability in drug response?

<p>Heredity</p> Signup and view all the answers

What is the key nursing responsibility related to drug administration?

<p>Intercepting medication errors made by others</p> Signup and view all the answers

How is the therapeutic index calculated?

<p>ED50/LD50</p> Signup and view all the answers

What is the process by which a drug travels to the site of action and is removed from the site of action?

<p>Distribution</p> Signup and view all the answers

In pharmacology, what does ADME stand for?

<p>Absorption, Distribution, Metabolism, Excretion</p> Signup and view all the answers

According to the relative absorption rates, which form of drug has the fastest absorption?

<p>Liquids, elixirs, syrups</p> Signup and view all the answers

What is the study of interactions of drugs and living tissues called?

<p>Pharmacodynamics</p> Signup and view all the answers

What is the science of drugs known as?

<p>Pharmacology</p> Signup and view all the answers

What is the process by which a drug moves from its site of administration across body membranes and into circulating fluids?

<p>Absorption</p> Signup and view all the answers

What is the main characteristic of weakly acidic drugs when dissolved in water?

<p>They dissociate into a negatively charged anion and a proton</p> Signup and view all the answers

In which environment are weakly acidic drugs poorly absorbed?

<p>Basic environment such as the intestines</p> Signup and view all the answers

What determines the increased absorption of weakly acidic drugs?

<p>Decrease in pH of the solution</p> Signup and view all the answers

What is the main characteristic of weakly basic drugs in acidic environments?

<p>They remain in non-polar form and are absorbed in the stomach</p> Signup and view all the answers

Which equation summarizes the finding that weakly acidic drugs remain in their non-polar form in acidic environments?

<p>[A-] pH = pKa + log [AH]</p> Signup and view all the answers

In which environment do weakly basic drugs become polar and poorly absorbed?

<p>Acidic environment like the stomach</p> Signup and view all the answers

What determines the increased absorption of weakly basic drugs?

<p>Decrease in pH of the solution</p> Signup and view all the answers

What characteristic makes non-polar, fat-soluble drugs easily distributed in the body?

<p>'Unbound' state</p> Signup and view all the answers

'Apparent Volume of Distribution (Vd)' is expressed in which units?

<p>$L/kg$</p> Signup and view all the answers

'Vd verses Low Vd' and 'High Vd' are related to which factor influencing drug distribution?

<p>$Drug structure$</p> Signup and view all the answers

According to Katzung & Vanderah (2024) and Wainman, McDonald & Murray-Davis (2019), what is the theoretical volume into which a drug is distributed in the body known as?

<p>Apparent Volume of Distribution (Vd)</p> Signup and view all the answers

What is the term for the process by which a drug travels to the site of action and is removed from the site of action?

<p>Pharmacokinetics</p> Signup and view all the answers

Which factor influences the movement of a drug from its site of administration across body membranes and into circulating fluids?

<p>Presence of excipients</p> Signup and view all the answers

In which form do drugs have the fastest absorption according to relative absorption rates?

<p>Rapid-dissolving tablets</p> Signup and view all the answers

What determines the clearance/removal of the drug from the body?

<p>Excretion</p> Signup and view all the answers

Which process involves the reversible movement of a drug from the bloodstream into cells and extracellular fluid?

<p>Distribution</p> Signup and view all the answers

What is the main characteristic of weakly acidic drugs when dissolved in water?

<p>They ionize and become polar</p> Signup and view all the answers

What is the theoretical volume into which a drug is distributed in the body known as?

<p>Volume of Distribution (Vd)</p> Signup and view all the answers

What contributes to the variability in drug response in pharmacogenetics/genomics?

<p>Genetic factors</p> Signup and view all the answers

What is the term used to describe a physiologic or psychological need for a drug?

<p>Dependence</p> Signup and view all the answers

How is the therapeutic index calculated?

<p>LD50/ED50</p> Signup and view all the answers

What term describes the secondary or unwanted effects of a drug on other systems?

<p>Toxic effects</p> Signup and view all the answers

In pharmacogenetics/genomics, what contributes to drug response variability?

<p>All of the above</p> Signup and view all the answers

What is the rough indication of the relative safety of a drug known as?

<p>Therapeutic Index</p> Signup and view all the answers

What characteristic makes gastric pH less acidic and gastric emptying slower in pediatrics?

<p>Greater fat content in TBW</p> Signup and view all the answers

Which factor contributes to personalized drug therapy and drug response variability in pharmacogenetics/genomics?

<p>Genetic profiling</p> Signup and view all the answers

What is the key nursing responsibility related to drug administration according to the text?

<p>Preventing medication errors</p> Signup and view all the answers

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