Drug Definitions and Classifications
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Questions and Answers

Which of the following best describes the action of a negative chronotropic drug?

  • Decreases heart rate. (correct)
  • Increases heart rate.
  • Increases the force of myocardial contraction.
  • Decreases blood pressure.
  • Which of the following conditions is a positive inotropic drug primarily used to treat?

  • Ventricular arrhythmias
  • Hypertension
  • Congestive heart failure (correct)
  • Tachycardia
  • What is the primary effect of epinephrine on cardiac function?

  • Decreases the force of contraction while increasing heart rate.
  • Decreases heart rate and blood pressure.
  • Increases conduction time in the heart.
  • Increases heart rate and force of contraction, and increases blood pressure. (correct)
  • Dopamine is used to treat which of the following conditions, based on its cardiac effects?

    <p>Acute heart failure (B)</p> Signup and view all the answers

    Which of the following best describes the therapeutic action of dobutamine?

    <p>Increases heart contraction in cases of cardiac depression with hypotension. (D)</p> Signup and view all the answers

    Which of the following best describes the dual action of Digoxin?

    <p>Increases strength of contraction while decreasing heart rate. (D)</p> Signup and view all the answers

    Which of the following best describes the primary purpose of administering a drug?

    <p>To diagnose, treat, or prevent disease, relieve pain, or improve physiological function. (A)</p> Signup and view all the answers

    Pimobendan is primarily used to treat congestive heart failure (CHF) through which mechanism?

    <p>By causing vasodilation. (C)</p> Signup and view all the answers

    Procainamide is used to treat VPC by which mechanism?

    <p>Increasing conduction time. (D)</p> Signup and view all the answers

    What distinguishes an over-the-counter (OTC) drug from a prescription drug?

    <p>OTC drugs can be purchased without a prescription, while prescription drugs require one. (B)</p> Signup and view all the answers

    What is the determining factor for 'extra-label drug use'?

    <p>Prescribing a drug for a use not specifically listed on its label. (C)</p> Signup and view all the answers

    Propranolol and Atenolol are similar in that they both:

    <p>Decrease automaticity. (A)</p> Signup and view all the answers

    What is the main goal of drug compounding?

    <p>To create a customized medication for a specific patient. (B)</p> Signup and view all the answers

    What distinguishes Class III antiarrhythmic drugs from other classes?

    <p>They block potassium channels. (A)</p> Signup and view all the answers

    Which aspect of a prescription label indicates how long a medication should be administered?

    <p>Duration of treatment. (A)</p> Signup and view all the answers

    What does the 'therapeutic range' of a drug refer to?

    <p>The concentration of a drug in the body that produces a desired effect with minimal toxicity. (C)</p> Signup and view all the answers

    What is the primary purpose of administering a loading dose of a drug?

    <p>To quickly reach the therapeutic range of the drug. (C)</p> Signup and view all the answers

    What does it indicate if a drug has a low margin of safety?

    <p>The effective dose is close to the lethal dose. (A)</p> Signup and view all the answers

    What effect does protein binding typically have on drug distribution within the body?

    <p>It slows drug distribution by binding drug molecules to blood proteins. (D)</p> Signup and view all the answers

    Pancuronium is a neuromuscular blocker that interferes with the action of which neurotransmitter?

    <p>Acetylcholine (C)</p> Signup and view all the answers

    Which drug is described as an anticonvulsant that requires monitoring due to its low therapeutic index?

    <p>Potassium bromide (B)</p> Signup and view all the answers

    What is the primary use of phenobarbital in veterinary medicine?

    <p>Anticonvulsant (B)</p> Signup and view all the answers

    Which drug should be avoided in patients with hypertension due to its effects on blood pressure?

    <p>Phenylephrine (A)</p> Signup and view all the answers

    What is the function of goblet cells and cilia in the respiratory tract?

    <p>Trap and remove foreign material (B)</p> Signup and view all the answers

    What class of drugs is used to suppress a non-productive cough?

    <p>Antitussives (A)</p> Signup and view all the answers

    What is the role of mucolytics in respiratory treatment?

    <p>Thins and loosens mucus (B)</p> Signup and view all the answers

    Which medication is noted for its use in treating acetaminophen toxicity in cats and dogs?

    <p>Acetylcysteine (B)</p> Signup and view all the answers

    What do terbutaline and albuterol have in common?

    <p>They are both β2-adrenergic agonists (D)</p> Signup and view all the answers

    What is the mechanism of action for methylxanthine bronchodilators?

    <p>Inhibit bronchial smooth muscle contraction (A)</p> Signup and view all the answers

    What is the application of Guaifenesin in veterinary medicine?

    <p>Increase liquid secretion (C)</p> Signup and view all the answers

    What is the primary use of Diltiazem?

    <p>To reduce spontaneous depolarization (C)</p> Signup and view all the answers

    What is the function of ACE Inhibitors?

    <p>Promote vasodilation and reduce cardiac afterload (B)</p> Signup and view all the answers

    What distinguishes sympathomimetics?

    <p>They mimic the effects of the sympathetic nervous system (B)</p> Signup and view all the answers

    What is the primary role of Amlodipine?

    <p>To treat hypertension and inhibit Ca2+ movement (C)</p> Signup and view all the answers

    What is the mechanism by which Acetylsalicylic Acid prevents clot formation?

    <p>By inhibiting thromboxane (A)</p> Signup and view all the answers

    What do hemostatic drugs achieve?

    <p>They stop bleeding by promoting clotting (A)</p> Signup and view all the answers

    What do arteriolar dilators primarily do?

    <p>Promote relaxation of arteriolar smooth muscle (D)</p> Signup and view all the answers

    What is the effect of parasympatholytic drugs?

    <p>They block acetylcholine actions (B)</p> Signup and view all the answers

    What is the purpose of EDTA in medical treatments?

    <p>To prevent clot formation by chelating Ca2+ (C)</p> Signup and view all the answers

    What is the primary neurotransmitter associated with the parasympathetic nervous system?

    <p>Acetylcholine (C)</p> Signup and view all the answers

    Flashcards

    Drug

    A substance administered to diagnose, treat, or prevent disease, relieve pain, or improve physiological function.

    Over-the-Counter (OTC) Drug

    A drug that can be purchased without a prescription.

    Extra-Label Drug Use

    When a veterinarian prescribes a drug for a use not specifically listed on its label.

    Drug Compounding

    The process of combining or altering drugs to create a customized medication for a specific patient.

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    Duration of Treatment

    The timeframe specified for administering a medication as indicated on a prescription label.

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    Therapeutic Range

    The concentration of a drug in the body that produces a desired effect with minimal toxicity.

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    Loading Dose

    A higher initial dose of a drug given to quickly reach therapeutic range.

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    Low Margin of Safety

    When a drug's effective dose is close to its lethal dose, indicating a small safety buffer.

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    High Margin of Safety

    When the lethal dose is much greater than the effective dose, indicating a safer drug profile.

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    Protein Binding

    The process where drug molecules bind to blood proteins, slowing their distribution in the body.

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    Diltiazem vs Verapamil

    Drugs that reduce spontaneous depolarization and treat Ventricular Tachycardia.

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    Amlodipine

    A medication that treats Hypertension by inhibiting Ca2+ movement.

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    Vasodilator

    A drug that opens constricted blood vessels, easing heart's blood flow.

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    ACE Inhibitors

    Drugs that inhibit angiotensin-converting enzyme, leading to vasodilation and reduced afterload.

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    Acetylsalicylic Acid

    Prevents clot formation by inhibiting thromboxane, a platelet adhesive substance.

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    EDTA

    A chelator that binds Ca2+, used for blood tests or lead poisoning treatment.

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    Heparin

    A drug that halts conversion of prothrombin to thrombin, used in blood tests or transfusions.

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    Hemostatic Drugs

    Medications that promote clotting to stop bleeding.

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    Blood Enhancing Drugs

    Substances that stimulate red blood cell production, like Iron and Erythropoietin.

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    Sympathetic Nervous System

    System responsible for the body's "fight or flight" response.

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    Negative chronotropic drugs

    Drugs that decrease heart rate, used to treat tachycardia.

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    Positive inotropic drugs

    Drugs that increase the force of myocardial contraction, used for congestive heart failure (CHF).

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    Negative inotropic drugs

    Drugs that decrease the force of myocardial contraction, used to treat hypertension.

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    Epinephrine

    Cardiac stimulant that increases force and rate of contraction; used in cardiac and respiration arrest.

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    Dopamine

    Cardiac stimulant that increases blood pressure and heart rate; treats acute heart failure.

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    Dobutamine

    Cardiac stimulant that increases heart contraction; treats cardiac depression with hypotension.

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    Digoxin

    Increases strength of contraction and decreases heart rate; used to treat CHF.

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    Procainamide

    Membrane stabilizer that increases conduction time; treats ventricular premature contractions (VPC).

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    Propranolol

    Beta-adrenergic blocker that decreases automaticity; treats ventricular arrhythmias.

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    Sotalol

    Potassium channel blocker that helps control heart rhythm and treats arrhythmias.

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    Diazepam

    A benzodiazepine used to enhance GABA activity for anxiety and sedation.

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    Potassium bromide

    An anticonvulsant with a low therapeutic index, monitored in dogs.

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    Acepromazine

    A drug used for sedation and as an anti-emetic.

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    Xylazine

    Used for sedation and anti-emetic, effective for GI pain in horses.

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    Dexmedetomidine

    A sedative drug used for sedation and analgesia.

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    Guaifenesin

    A medication used to increase liquid secretion and relax muscles in horses.

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    Mucolytics

    Drugs that help break down thick mucus in wet coughs.

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    Expectorants

    Drugs that increase respiratory secretions to clear mucus.

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    Terbutaline

    A β2-adrenergic agonist used for respiratory issues, especially in cats.

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    Anticholinergics

    Drugs that block acetylcholine to prevent bronchoconstriction.

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    Study Notes

    Drug Definitions and Classifications

    • A drug is a substance administered to diagnose, treat, or prevent disease; relieve pain; or improve physiological function.
    • An over-the-counter (OTC) drug can be purchased without a prescription.
    • Extra-label drug use occurs when a veterinarian prescribes a drug for a use not explicitly listed on its label.
    • Drug compounding combines or alters drugs to create a customized medication for a specific patient.
    • Duration of treatment refers to the timeframe for administration, which is often included on a prescription label with details like dosage, route, and frequency.
    • The therapeutic range is the drug concentration in the body that produces a desired effect with minimal toxicity.
    • A loading dose is a higher initial amount of a drug given to quickly reach the therapeutic range.

    Drug Properties

    • Low margin of safety means a drug's effective dose is close to its lethal dose.
    • High margin of safety occurs when the lethal dose is greater than the effective dose.
    • Protein binding is the process of drug molecules binding to blood proteins (like albumin) which may slow their distribution.
    • Ion trapping is when a drug becomes trapped in a body compartment due to differences in pH.

    Cardiovascular Drugs

    • Acetylcholine is a neurotransmitter released at the neuromuscular junction to stimulate muscle contraction.
    • Pancuronium is a neuromuscular blocker that competes with acetylcholine for receptor sites and requires a reversal agent for muscle function restoration.
    • Positive dromotropic drugs increase conduction of myocardial electrical impulses, used to treat heart block.
    • Negative dromotropic drugs decrease conduction of myocardial electrical impulses, used to treat atrioventricular (AV) block.
    • Positive chronotropic drugs increase heart rate, used to treat bradycardia.
    • Negative chronotropic drugs decrease heart rate, used to treat tachycardia.
    • Positive inotropic drugs increase the force of myocardial contraction, used to treat congestive heart failure.
    • Negative inotropic drugs decrease the force of myocardial contraction, used to treat hypertension.
    • Dopamine is a cardiac stimulant used to increase blood pressure, heart rate, and contraction.
    • Dobutamine is a cardiac stimulant used to increase heart contraction and treat cardiac depression with hypotension.
    • Digoxin and Digitoxin increase the strength of contraction and decrease heart rate, used to treat congestive heart failure (CHF).
    • Pimobendane is a vasodilator used to treat CHF.
    • Procainamide and Quinidine increase conduction time, used to treat ventricular premature complexes (VPCs) and ventricular arrhythmias.
    • Tocainide and Lidocaine increase conduction time, used to treat ventricular tachycardia.
    • Propranolol is a beta-blocker used to decrease automaticity (slow depolarization phase), treating ventricular arrhythmias.
    • Atenolol is a beta-blocker used to decrease automaticity, treating hypertension.
    • Sotolol, Amiodarone, and Bretylium are potassium channel blockers used to treat ventricular arrhythmias and reduce sinus rate.
    • Diltiazem and Verapamil reduce spontaneous depolarization, treating ventricular tachycardia.
    • Amlodipine treats hypertension and inhibits calcium movement, acting as a vasodilator.

    Miscellaneous Drugs

    • ACE inhibitors inhibit angiotensin-converting enzyme, leading to vasodilation and reduced cardiac afterload.
    • Acetylsalicylic acid (aspirin) prevents clot formation by inhibiting thromboxane, affecting platelet stickiness.
    • EDTA chelates calcium ions, preventing clot formation and used for blood tests or to chelate lead poison.
    • Heparin stops the conversion of prothrombin to thrombin, used in blood tests or transfusions.
    • Hemostatic drugs promote clotting to stop bleeding (e.g., silver nitrate, vitamin K, protamine sulfate).
    • Blood-enhancing drugs (e.g., iron, erythropoietin) increase red blood cell production in the kidneys.
    • Potassium bromide is an anticonvulsant used in dogs, with closely monitored blood levels due to its low therapeutic index.
    • Acepromazine is used for sedation and as an anti-emetic.
    • Xylazine treats pain and is used for sedation.
    • Doxapram treats respiratory depression or arrest.
    • Dexmedetomidine provides sedation and analgesia.

    Nervous System Drugs

    • Sympathetic nervous system is responsible for "fight or flight".
    • Parasympathetic nervous system is responsible for energy-saving functions with acetylcholine as the primary neurotransmitter.
    • Sympathomimetics mimic the sympathetic nervous system's effects.
    • Sympatholytics inhibit the sympathetic nervous system.
    • Parasympathomimetics mimic the parasympathetic nervous system's effects.
    • Parasympatholytics inhibit the parasympathetic nervous system.
    • Diazepam is a GABA inhibitory neurotransmitter.
    • Pentobarbital is a barbiturate used in euthanasia.

    Respiratory Drugs

    • Goblet cells and cilia help remove foreign material in the respiratory tract.
    • Antitussives suppress non-productive coughs.
    • Anticholinergics block acetylcholine receptors and prevent bronchoconstriction.
    • Acetylcysteine is a mucolytic drug used to treat acetaminophen toxicity in animals.
    • Guaifenesin increases liquid secretion.
    • Phenylephrine is a decongestant used to decrease nasal passage blockage.
    • Methylxanthine bronchodilators inhibit enzymes that promote bronchoconstriction.
    • Terbutaline and albuterol are beta2-adrenergic agonist drugs used to treat feline asthma.

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