17 Questions
What is the main challenge in treating cancer despite advances in modern medical sciences?
Cancer remains a disease difficult to treat.
What is the principal aim of radiotherapy and chemotherapy in cancer treatment?
To eradicate solid tumors located deep inside the body.
How does chemotherapy (chemo) work in treating cancer?
It uses medicines or drugs to treat cancer.
What is the mechanism of action of radiation therapy in cancer treatment?
It uses high-energy particles or waves to destroy or damage cancer cells.
What is immunotherapy in the context of cancer treatment?
Treatment that uses the body's own immune system to fight cancer.
How does stem cell transplant contribute to cancer treatment?
It is used to treat cancer.
What is the role of P-glycoprotein (P-gp) in cellular resistance to Vincristine (VCR)?
P-glycoprotein (P-gp) overexpression on cancer cell membranes leads to cellular resistance to Vincristine (VCR).
How can the effectiveness of Vincristine (VCR) be increased in cancer treatment?
Conjugation of paclitaxel or vincristine with nanoparticles can augment drug delivery and increase treatment effectiveness.
What is the first biological barrier to siRNA delivery in cancer therapy?
The susceptibility of siRNA to nucleases, causing rapid degradation when administered, is the first biological barrier to siRNA delivery.
Why is delivering siRNA into cells a challenge in cancer therapy?
Delivering siRNA into cells is challenging due to the need to overcome cellular barriers for its desired functions.
What is the main reason for the short circulation time of siRNA in the blood for its therapeutic effects?
The susceptibility of siRNA to nucleases causes rapid degradation, leading to a short circulation time in the blood.
How does doxorubicin induce apoptosis?
Activation of AMPK
What is the most serious long-term adverse effect of Doxorubicin therapy?
Irreversible cardiomyopathy
What is the role of reactive oxygen species in Doxorubicin cardiomyopathy?
Increased levels of reactive oxygen species result in apoptosis in the heart.
How are efforts made to mitigate Doxorubicin cardiomyopathy?
Via liposomal drug delivery NPs
What is the mechanism of action of Paclitaxel in cancer treatment?
Interferes with mitotic assembly of tubulin
How does Vincristine sulfate (vincristine) suppress cancer cell proliferation?
By blocking mitosis via inhibiting tubulin formation
Test your knowledge about the chemotherapeutic drug Doxorubicin. Learn about its mechanism of action, induction of apoptosis, and long-term adverse effects such as irreversible cardiomyopathy.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
