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Doxorubicin Chemotherapy Quiz

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Questions and Answers

What is the main challenge in treating cancer despite advances in modern medical sciences?

Cancer remains a disease difficult to treat.

What is the principal aim of radiotherapy and chemotherapy in cancer treatment?

To eradicate solid tumors located deep inside the body.

How does chemotherapy (chemo) work in treating cancer?

It uses medicines or drugs to treat cancer.

What is the mechanism of action of radiation therapy in cancer treatment?

It uses high-energy particles or waves to destroy or damage cancer cells. Signup and view all the answers

What is immunotherapy in the context of cancer treatment?

Treatment that uses the body's own immune system to fight cancer. Signup and view all the answers

How does stem cell transplant contribute to cancer treatment?

It is used to treat cancer. Signup and view all the answers

What is the role of P-glycoprotein (P-gp) in cellular resistance to Vincristine (VCR)?

P-glycoprotein (P-gp) overexpression on cancer cell membranes leads to cellular resistance to Vincristine (VCR). Signup and view all the answers

How can the effectiveness of Vincristine (VCR) be increased in cancer treatment?

Conjugation of paclitaxel or vincristine with nanoparticles can augment drug delivery and increase treatment effectiveness. Signup and view all the answers

What is the first biological barrier to siRNA delivery in cancer therapy?

The susceptibility of siRNA to nucleases, causing rapid degradation when administered, is the first biological barrier to siRNA delivery. Signup and view all the answers

Why is delivering siRNA into cells a challenge in cancer therapy?

Delivering siRNA into cells is challenging due to the need to overcome cellular barriers for its desired functions. Signup and view all the answers

What is the main reason for the short circulation time of siRNA in the blood for its therapeutic effects?

The susceptibility of siRNA to nucleases causes rapid degradation, leading to a short circulation time in the blood. Signup and view all the answers

How does doxorubicin induce apoptosis?

Activation of AMPK Signup and view all the answers

What is the most serious long-term adverse effect of Doxorubicin therapy?

Irreversible cardiomyopathy Signup and view all the answers

What is the role of reactive oxygen species in Doxorubicin cardiomyopathy?

Increased levels of reactive oxygen species result in apoptosis in the heart. Signup and view all the answers

How are efforts made to mitigate Doxorubicin cardiomyopathy?

Via liposomal drug delivery NPs Signup and view all the answers

What is the mechanism of action of Paclitaxel in cancer treatment?

Interferes with mitotic assembly of tubulin Signup and view all the answers

How does Vincristine sulfate (vincristine) suppress cancer cell proliferation?

By blocking mitosis via inhibiting tubulin formation Signup and view all the answers

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