Dosage regimens
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Questions and Answers

What is the primary goal of determining a dosage regimen in pharmacology?

  • To achieve the highest possible drug concentration in the body
  • To minimize drug absorption and excretion
  • To achieve maximum benefit with minimal risk of toxicity (correct)
  • To eliminate the need for clinical trials

Why is achieving a steady state (PK) important in a dosage regimen?

  • It ensures the drug reaches the highest concentration in the body
  • It helps maintain consistent therapeutic effects over time (Pharmacodynamics) (correct)
  • It completely eliminates the risk of drug toxicity
  • It prevents the need for loading doses

When is intermittent dosing appropriate to do?

It’s done when a relative wide therapeutic window considering PK of the drug.

What is a key consideration when using intermittent dosing for drugs with a short half-life?

<p>The drug’s effects last long enough between doses (A)</p> Signup and view all the answers

Why can drugs with a long half-life be given less frequently in an intermittent dosing regimen?

<p>Their effects persist longer, maintaining efficacy between doses (B)</p> Signup and view all the answers

An example of using intermittent dosing as a practical option for a drug would be when the drug has a short half life and short lasting effects

<p>False (B)</p> Signup and view all the answers

What is the main advantage of intermittent dosing for drugs with a long half-life?

<p>It reduces dosing frequency while maintaining effective drug levels (A)</p> Signup and view all the answers

Why is constant rate infusion (CRI) used instead of intermittent dosing for certain drugs?

<p>To maintain a consistent drug concentration and avoid peaks and troughs (A)</p> Signup and view all the answers

What are the three types of dosing regimens?

<p>Single administration, intermittent dosing and constant rate infusions</p> Signup and view all the answers

When is single administration of a drug typically indicated?

<p>When the condition responds immediately to a single dose or needs prevention (B)</p> Signup and view all the answers

Steady state = _________ equals the ______

<p>Dosing rate equals the elimination rate</p> Signup and view all the answers

Steady state is dependent on _____

<p>T1/2</p> Signup and view all the answers

What is the primary purpose of administering a loading drug dose?

<p>To achieve desired drug levels rapidly, especially in acute conditions (B)</p> Signup and view all the answers

A faster rate of infusion changes the time needed to achieve steady state

<p>False (B)</p> Signup and view all the answers

What are examples of analgesics used for CRI?

<p>Morphine, fentanyl, ketamine, lidocaine, and dexmedetomidine</p> Signup and view all the answers

What are examples of anticonvulsants used in CRI?

<p>Phenobarbital, diazepam and midazolam</p> Signup and view all the answers

Time dependent antibacterial/antimicrobials are used for CRI

<p>True (A)</p> Signup and view all the answers

Flashcards

Dosage Regimen Goal

Maximize benefit, minimize toxicity.

Steady State (PK) Importance

Consistent therapeutic effects over time.

When to Use Intermittent Dosing

When drug has wide therapeutic window relative to its PK.

Key Consideration: Short Half-Life, Intermittent Dosing

Drug's effects last long enough between doses.

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Long Half-Life & Dosing Frequency

Effects persist longer, efficacy maintained between doses.

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Advantage of Intermittent Dosing (Long Half-Life)

Reduces dosing frequency while maintaining effective drug levels.

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Why Use CRI Instead of Intermittent Dosing?

To maintain consistent drug concentration, avoid peaks and troughs.

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Three Types of Dosing Regimens

Single administration, intermittent dosing, and constant rate infusions.

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When to Use Single Administration

Condition responds immediately to a single dose or needs prevention.

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Steady State = ?

Dosing rate equals the elimination rate.

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Steady State Depends On...

Half-life (T1/2)

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Intermittent Dosing with Short Half Life and Short Lasting Effects is a practical option?

False. Effects must be long lasting.

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