Lecture 6
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Questions and Answers

What is the purpose of a dosage regimen?

  • To decrease the maintenance dose in liver or renal disease
  • To increase the risk of drug toxicity
  • To quickly achieve the volume of distribution
  • To maintain plasma concentration within therapeutic levels (correct)

    • What is the formula for the maintenance dose?

  • Cp x Dose interval
  • Cp x Vd x F
  • Cp x Cl x Dose interval (correct)
  • Cp x Cl

    • What does the loading dose aim to achieve?

  • Increase the risk of drug toxicity
  • Decrease the maintenance dose in liver or renal disease
  • Quickly achieve the volume of distribution and desired plasma level (correct)
  • Maintain plasma concentration within therapeutic levels

    • What is the purpose of reaching steady state in pharmacokinetics?

    <p>To maintain a constant rate of drug administration</p> Signup and view all the answers

    What is the disadvantage of loading doses if excess levels occur?

    <p>Increased risk of drug toxicity</p> Signup and view all the answers

    What determines the time needed to reach steady state in pharmacokinetics?

    <p>Half-life of the drug</p> Signup and view all the answers

    What is the primary purpose of a maintenance dose in pharmacology?

    <p>Maintain plasma concentration within therapeutic levels</p> Signup and view all the answers

    In what conditions would the maintenance dose be decreased?

    <p>In liver or renal disease</p> Signup and view all the answers

    'Steady state' in pharmacokinetics is reached in how many half-lives?

    <p>~5 t1/2</p> Signup and view all the answers

    'Rate in=Rate out' signifies which pharmacokinetic concept?

    <p>Steady state</p> Signup and view all the answers

    Which of the following best defines bioavailability?

    <p>The percentage of the dose of a drug that is actually absorbed into the bloodstream</p> Signup and view all the answers

    What factors can affect bioavailability?

    <p>Differences in drug formulation</p> Signup and view all the answers

    What is the formula for calculating bioavailability (F)?

    <p>F = AUC(oral) / AUC(IV) x 100%</p> Signup and view all the answers

    What is therapeutic equivalence in terms of drug effects and safety profile?

    <p>Same effect and safety profile</p> Signup and view all the answers

    Which parameter is used to calculate dosage regimen related to loading dose, dosing rate, maintenance dose, and steady-state bioavailability?

    <p>Bioavailability</p> Signup and view all the answers

    What is the bioavailability of a drug if it has an oral AUC of 20 mg.hr/ml and an intravenous AUC of 60 mg.hr/ml?

    <p>33%</p> Signup and view all the answers

    Which factor does not affect bioavailability?

    <p>Differences in drug taste</p> Signup and view all the answers

    What pharmacokinetic parameter does bioavailability fall under?

    <p>Absorption</p> Signup and view all the answers

    Which term describes the same effect and safety profile in the treatment of a disease/condition?

    <p>Therapeutic equivalence</p> Signup and view all the answers

    What does the term 'Therapeutic equivalence' refer to in pharmacology?

    <p>Similar clinical efficacy in the treatment of a disease/condition</p> Signup and view all the answers

    Which factor affects bioavailability based on the information provided?

    <p>GI absorption affect factors</p> Signup and view all the answers

    What is the formula for calculating bioavailability (F) based on the given example?

    <p>F = AUC(oral) / AUC(IV)</p> Signup and view all the answers

    What is the primary purpose of a maintenance dose in pharmacology?

    <p>To maintain steady-state drug levels</p> Signup and view all the answers

    What does 'Rate in=Rate out' signify in pharmacokinetics?

    <p>Steady-state equilibrium</p> Signup and view all the answers

    What pharmacokinetic parameter does bioavailability fall under?

    <p>Absorption</p> Signup and view all the answers

    In what conditions would the maintenance dose be decreased according to pharmacological principles?

    <p>In patients with a high metabolic rate</p> Signup and view all the answers

    'Steady state' in pharmacokinetics is reached in how many half-lives?

    <p>3 to 4</p> Signup and view all the answers

    What is the disadvantage of loading doses if excess levels occur?

    <p>Increased risk of adverse effects</p> Signup and view all the answers

    What is the formula for calculating the loading dose (Ld) in pharmacokinetics?

    <p>Ld = CpxVd</p> Signup and view all the answers

    What is the disadvantage of loading doses if excess levels occur in pharmacokinetics?

    <p>Increased risk of drug toxicity</p> Signup and view all the answers

    Which formula represents the maintenance dose (Md) in pharmacokinetics?

    <p>Md = Dosing Rate x Dose Interval</p> Signup and view all the answers

    When reaching steady-state in pharmacokinetics, what does the rate in equal to?

    <p>Rate out</p> Signup and view all the answers

    In what conditions would the maintenance dose be decreased in pharmacokinetics?

    <p>In liver or renal disease</p> Signup and view all the answers

    What determines the time needed to reach steady state in pharmacokinetics?

    <p>Half-life of the drug</p> Signup and view all the answers

    'Steady-state' in pharmacokinetics is reached in how many half-lives?

    <p>4-5 half-lives</p> Signup and view all the answers

    'Must have comparable efficacy and safety' refers to which concept in pharmacology?

    <p>Therapeutic equivalence</p> Signup and view all the answers

    What is the primary purpose of a dosage regimen in pharmacokinetics?

    <p>To maintain plasma concentration within therapeutic levels over time</p> Signup and view all the answers

    Which term describes the same effect and safety profile in the treatment of a disease/condition?

    <p>Therapeutic equivalence</p> Signup and view all the answers

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