10 Questions
At steady state, the plasma concentrations of a drug will be approximately reached after how many half-lives?
5 half-lives
For drugs like aspirin, ranitidine, and gentamicin, when do the therapeutic effects typically begin?
Before steady-state plasma concentrations are reached
Which parameter depends on dose, dosing interval, and clearance at steady state?
Cpss av
In multiple drug dosing at steady state, what would alter the observed peak and trough drug concentrations but not Cpss av if there is no change in clearance?
Changes in volume of distribution (V)
When calculating dosing rate, which concentration should be used?
Cpss av
What is the main reason for using a multiple dose regimen in most clinical situations?
To achieve a longer therapeutic effect
In the context of multiple dosing, what is the purpose of an intravenous bolus dose model?
To represent rapid IV doses at constant time intervals
What is the significance of the equation 'RATE OF DRUG GOING IN = RATE OF DRUG GOING OUT' in pharmacokinetics?
It indicates the equilibrium between drug absorption and elimination
What does 'Cl' represent in the context of injection or infusion dosing?
Drug clearance rate
What is the primary reason for not using an intravenous bolus dose model often in clinical practice?
It causes fluctuating drug levels in the body
Explore the concept of multiple dosage regimen in pharmacokinetics, including the administration of pain relievers, antibiotics, and drugs for inflammation, chronic diseases, and more. Understand the necessity of multiple doses for maintaining therapeutic effects over extended periods.
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