Pharmacokinetics: Multiple Dosage Regimen
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Questions and Answers

At steady state, the plasma concentrations of a drug will be approximately reached after how many half-lives?

  • 3 half-lives
  • 5 half-lives (correct)
  • 4 half-lives
  • 2 half-lives
  • For drugs like aspirin, ranitidine, and gentamicin, when do the therapeutic effects typically begin?

  • It varies and is unpredictable
  • Before steady-state plasma concentrations are reached (correct)
  • After steady-state plasma concentrations are reached
  • At the same time as steady-state plasma concentrations are reached
  • Which parameter depends on dose, dosing interval, and clearance at steady state?

  • Dosing rate
  • Cpss av (correct)
  • Cpmin
  • Cpmax
  • In multiple drug dosing at steady state, what would alter the observed peak and trough drug concentrations but not Cpss av if there is no change in clearance?

    <p>Changes in volume of distribution (V)</p> Signup and view all the answers

    When calculating dosing rate, which concentration should be used?

    <p>Cpss av</p> Signup and view all the answers

    What is the main reason for using a multiple dose regimen in most clinical situations?

    <p>To achieve a longer therapeutic effect</p> Signup and view all the answers

    In the context of multiple dosing, what is the purpose of an intravenous bolus dose model?

    <p>To represent rapid IV doses at constant time intervals</p> Signup and view all the answers

    What is the significance of the equation 'RATE OF DRUG GOING IN = RATE OF DRUG GOING OUT' in pharmacokinetics?

    <p>It indicates the equilibrium between drug absorption and elimination</p> Signup and view all the answers

    What does 'Cl' represent in the context of injection or infusion dosing?

    <p>Drug clearance rate</p> Signup and view all the answers

    What is the primary reason for not using an intravenous bolus dose model often in clinical practice?

    <p>It causes fluctuating drug levels in the body</p> Signup and view all the answers

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