Podcast
Questions and Answers
At steady state, the plasma concentrations of a drug will be approximately reached after how many half-lives?
At steady state, the plasma concentrations of a drug will be approximately reached after how many half-lives?
- 3 half-lives
- 5 half-lives (correct)
- 4 half-lives
- 2 half-lives
For drugs like aspirin, ranitidine, and gentamicin, when do the therapeutic effects typically begin?
For drugs like aspirin, ranitidine, and gentamicin, when do the therapeutic effects typically begin?
- It varies and is unpredictable
- Before steady-state plasma concentrations are reached (correct)
- After steady-state plasma concentrations are reached
- At the same time as steady-state plasma concentrations are reached
Which parameter depends on dose, dosing interval, and clearance at steady state?
Which parameter depends on dose, dosing interval, and clearance at steady state?
- Dosing rate
- Cpss av (correct)
- Cpmin
- Cpmax
In multiple drug dosing at steady state, what would alter the observed peak and trough drug concentrations but not Cpss av if there is no change in clearance?
In multiple drug dosing at steady state, what would alter the observed peak and trough drug concentrations but not Cpss av if there is no change in clearance?
When calculating dosing rate, which concentration should be used?
When calculating dosing rate, which concentration should be used?
What is the main reason for using a multiple dose regimen in most clinical situations?
What is the main reason for using a multiple dose regimen in most clinical situations?
In the context of multiple dosing, what is the purpose of an intravenous bolus dose model?
In the context of multiple dosing, what is the purpose of an intravenous bolus dose model?
What is the significance of the equation 'RATE OF DRUG GOING IN = RATE OF DRUG GOING OUT' in pharmacokinetics?
What is the significance of the equation 'RATE OF DRUG GOING IN = RATE OF DRUG GOING OUT' in pharmacokinetics?
What does 'Cl' represent in the context of injection or infusion dosing?
What does 'Cl' represent in the context of injection or infusion dosing?
What is the primary reason for not using an intravenous bolus dose model often in clinical practice?
What is the primary reason for not using an intravenous bolus dose model often in clinical practice?
