10 Questions
What is the function of RNA primase in DNA replication?
Synthesizes short RNA primers to provide a 3’ end for DNA polymerase
What is the role of the sliding clamp in DNA replication?
Binds to DNA polymerase and helps it stay attached to the template strand
Why are Okazaki fragments formed during DNA replication?
Due to the antiparallel orientation of the lagging strand
What is the enzyme responsible for degrading the RNA nucleotides in the RNA primers?
RNase H
Why does DNA polymerase require a pre-existing chain or primer to start the replication process?
To provide a 3’ end for the addition of nucleotides
What is the name of the repetitive sequences of DNA that protect the ends of eukaryotic chromosomes?
Telomeres
Which enzyme can extend the ends of the chromosomes by adding more telomeric repeats to the 3’ end of the lagging strand?
Telomerase
What is the first safeguard against mutations during DNA replication?
Proofreading function of DNA polymerase
What happens to telomeres with each cell division in eukaryotic cells?
They shorten
Which type of cells are vulnerable to cellular senescence or apoptosis due to telomere shortening?
Somatic cells not expressing telomerase
Test your knowledge of DNA replication with this quiz on primase and the initiation of DNA synthesis. Learn about the role of primase in providing RNA primers for DNA polymerase, and understand how this process enables the start of replication.
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