35 Questions
What is the target MAP during resuscitation?
60 mmHg
What is the platelet count target during resuscitation?
More than 50x10^9 /L
What is the expected INR value during resuscitation?
< 1.5
In the context of Hemophilia, which coagulation factor deficiency leads to Hemophilia A?
Factor VIII deficiency
What is the expected pH range during resuscitation?
$7.35-7.45$
Why is maintaining a Core temperature above 35 degrees C important during resuscitation?
It improves oxygen delivery
What is the difference between sickle cell trait and sickle cell disease?
Sickle cell trait involves having only one copy of the abnormal gene, while sickle cell disease involves having two copies.
What is the effect of reduced PaO2 in people with sickle cell disease?
Causes vasoconstriction
What should be avoided in a patient with sickle cell disease?
Dehydration and hypoxia
What are the 4 classes of hemorrhage?
Class I, Class II, Class III, Class IV
What is the ABC Score?
A scoring system used in activating massive transfusions
What are the targets of resuscitation when performing MTP?
To achieve hemostasis and correct coagulopathy
Which disorder is characterized by intravascular coagulation activation with microvascular thrombi formation, leading to bleeding and end-organ complications?
Disseminated Intravascular Coagulation
What does DIC result from?
Disorganized clotting and fibrinolysis
What is the primary goal of Massive Blood Transfusion (MBT)?
To rapidly deliver blood products to treat acute coagulopathy
Which condition is known for sickling of red blood cells at low oxygen levels, leading to tissue perfusion impairment and intense pain, especially in bones and joints?
Sickle cell disease
Which complication of Sickle Cell Disease (SCD) involves the spleen removing red blood cells from circulation faster than they are produced?
Sequestration crisis
What is the main reason for the implementation of Massive Transfusion Protocol (MTP) in trauma situations?
To establish communication with the blood bank and trauma team
Which of the following indicators is typically elevated in a patient with Acute Disseminated Intravascular Coagulation (DIC)?
Increased D-Dimer and Fibrin Degradation Products (FDPs)
In the context of anesthetic management, what issue arises with stored blood that is highlighted in the text?
Hyperkalemia
What is the primary goal of transfusion protocols according to the text?
To achieve hemostasis
What blood product plays a crucial role during Massive Transfusion Protocol (MTP)?
Fresh frozen plasma
Which of the following is a correct target during resuscitation in Massive Transfusion Protocol (MTP)?
MAP 60 mmHg
Which class of hemorrhage involves up to 30% blood volume loss and moderate tachycardia?
Class II
Sickle cell trait patients with a PaO2 of > 35 mmHg will not advance to what condition?
Sickle cell crisis
Patients with sickle cell trait have a higher risk of developing sickle cell disease compared to the general population.
False
The goal of transfusion protocols is to restore normal coagulation parameters in patients.
False
Massive transfusion protocols involve the use of blood products like platelets, cryoprecipitate, and fresh frozen plasma.
True
A Class II hemorrhage involves up to 40% blood volume loss and mild tachycardia.
False
The ABC Score is used in the activation of Massive Transfusion Protocols (MTP) to assess the severity of hemorrhage.
False
Stored blood may have increased levels of potassium due to potassium loss during storage.
False
Disseminated Intravascular Coagulation is characterized by microvascular thrombi formation, leading to end-organ complications and simultaneous bleeding.
True
Hemophilia A involves the spleen removing red blood cells from circulation faster than they are produced.
False
Maintaining a core temperature above 35 degrees Celsius is important during resuscitation to prevent hypothermia-related coagulopathy.
True
$MBT$ stands for Major Bleeding Threshold, which is crucial in guiding the initiation of transfusion protocols.
False
Test your knowledge on disorders of hemostasis including Disseminated Intravascular Coagulation (DIC), von Willebrand Disease, Hemophilia, Sickle Cell Anemia, Massive Blood Transfusion, and Thrombotic Disorders. Questions cover the description and management of various coagulopathies, massive blood transfusion (MBT) and massive transfusion protocol (MTP), as well as complications and banked-blood issues.
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