Hemorrhage - Hemophilia - VWF
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Hemorrhage - Hemophilia - VWF

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Questions and Answers

What is the most common inherited vascular bleeding disorder?

Hereditary Hemorrhagic Telangiectasia

What is the primary characteristic of Ehlers-Danlos Syndrome?

Hyperextensible joints and hyperelastic skin

Which of the following is a sign of a possible hemostatic defect?

Bleeding that is delayed or recurrent

What is the inheritance pattern of Hereditary Hemorrhagic Telangiectasia?

<p>Autosomal dominant</p> Signup and view all the answers

Which of the following is NOT a generalized bleeding sign?

<p>Epistaxis lasting less than 5 minutes</p> Signup and view all the answers

What condition includes unintentional injury and accounts for most fatal hemorrhage?

<p>Acute Coagulopathy of Trauma-Shock (ACOTS)</p> Signup and view all the answers

In massive transfusion, when is plasma transfusion used?

<p>In patients with preexisting single coagulation factor deficiency</p> Signup and view all the answers

What is the primary criterion for RBC transfusion in massive transfusion management?

<p>$1.5 \times$ the mean PT value</p> Signup and view all the answers

Which condition requires the administration of more than 3 RBC units within 1 hour or 8-10 units within 24 hours under massive transfusion management?

<p>ACOTS</p> Signup and view all the answers

When is Activated Prothrombin complex concentrate (PCC) ordered?

<p>When there is a Factor VIII inhibitor</p> Signup and view all the answers

Which of the following triggers Acute Coagulopathy of Trauma-Shock (ACOTS)?

<p>$Hypothermia$</p> Signup and view all the answers

Which of the following is NOT a cause of decreased platelet production?

<p>Heparin-Induced Thrombocytopenia</p> Signup and view all the answers

Which of the following is a type of autonomous thrombocytosis (primary thrombocytosis)?

<p>Essential Thrombocythemia</p> Signup and view all the answers

What is the primary cause of Thrombotic Thrombocytopenic Purpura (TTP)?

<p>Deficiency of ADAMTS13 enzyme</p> Signup and view all the answers

Which of the following is a cause of reactive thrombocytosis (secondary thrombocytosis)?

<p>Major surgery</p> Signup and view all the answers

Which of the following is a genetic disorder associated with MYH9 gene mutations?

<p>Fechtner syndrome</p> Signup and view all the answers

What is the main characteristic of autonomous thrombocytosis (primary thrombocytosis)?

<p>Marked increase in platelet count</p> Signup and view all the answers

Which of the following conditions is characterized by skeletal defects such as long extremities and spider fingers?

<p>Marfan's Syndrome</p> Signup and view all the answers

In which condition are bruised areas commonly seen on the forearms of the elderly due to collagen degeneration?

<p>Senile Purpura</p> Signup and view all the answers

Which condition is most commonly seen in children and is characterized by gastrointestinal hemorrhage and joint swelling?

<p>Henoch-Schonlein Purpura</p> Signup and view all the answers

Which condition involves the adrenal glands and is characterized by severe capillary damage following meningococcal septicemia?

<p>Waterhouse-Friedrichsen Syndrome</p> Signup and view all the answers

Which condition is associated with tumors composed of vessels that commonly swell and bleed at the surface, leading to a localized consumptive coagulopathy and risk for disseminated intravascular coagulation (DIC)?

<p>Kasabach-Merritt Syndrome</p> Signup and view all the answers

Which condition is characterized by defects in the synthesis of collagen and hyaluronic acid due to a deficiency of ascorbic acid (vitamin C)?

<p>Scurvy</p> Signup and view all the answers

Which of the following is a characteristic of an acquired bleeding disorder?

<p>Bleeding episodes begin after childhood</p> Signup and view all the answers

What type of hemorrhage is characterized by systemic bleeding that appears as petechiae, purpura, or ecchymosis?

<p>Mucocutaneous hemorrhage</p> Signup and view all the answers

Which of the following is an indication of congenital hemorrhagic disorders?

<p>Hemorrhage into joints, CNS, soft tissues &amp; peritoneum</p> Signup and view all the answers

Which type of hemorrhage is seen in acquired or congenital defects in secondary hemostasis or plasma coagulopathies?

<p>Soft tissue hemorrhage</p> Signup and view all the answers

What is the prevalence of congenital bleeding disorders?

<p>Occurring in fewer than 1/100 people</p> Signup and view all the answers

Which of the following is a potential cause of the bleeding disorders described in the text?

<p>Single/multiple coagulation factor deficiencies</p> Signup and view all the answers

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