Hemorrhage - Hemophilia - VWF
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Questions and Answers

What is the most common inherited vascular bleeding disorder?

  • Cutis Hyperelastica
  • Hereditary Hemorrhagic Telangiectasia (correct)
  • Ehlers-Danlos Syndrome
  • Osler-Weber-Rendu Disease
  • What is the primary characteristic of Ehlers-Danlos Syndrome?

  • Recurrent chronic bruising in multiple locations
  • Localized dilation of capillary walls
  • Hyperextensible joints and hyperelastic skin (correct)
  • Vomiting of blood
  • Which of the following is a sign of a possible hemostatic defect?

  • Menorrhagia with appropriate bleeding
  • Epistaxis lasting less than 10 minutes
  • Bleeding that is delayed or recurrent (correct)
  • Petechiae larger than 1cm in diameter
  • What is the inheritance pattern of Hereditary Hemorrhagic Telangiectasia?

    <p>Autosomal dominant</p> Signup and view all the answers

    Which of the following is NOT a generalized bleeding sign?

    <p>Epistaxis lasting less than 5 minutes</p> Signup and view all the answers

    What condition includes unintentional injury and accounts for most fatal hemorrhage?

    <p>Acute Coagulopathy of Trauma-Shock (ACOTS)</p> Signup and view all the answers

    In massive transfusion, when is plasma transfusion used?

    <p>In patients with preexisting single coagulation factor deficiency</p> Signup and view all the answers

    What is the primary criterion for RBC transfusion in massive transfusion management?

    <p>$1.5 \times$ the mean PT value</p> Signup and view all the answers

    Which condition requires the administration of more than 3 RBC units within 1 hour or 8-10 units within 24 hours under massive transfusion management?

    <p>ACOTS</p> Signup and view all the answers

    When is Activated Prothrombin complex concentrate (PCC) ordered?

    <p>When there is a Factor VIII inhibitor</p> Signup and view all the answers

    Which of the following triggers Acute Coagulopathy of Trauma-Shock (ACOTS)?

    <p>$Hypothermia$</p> Signup and view all the answers

    Which of the following is NOT a cause of decreased platelet production?

    <p>Heparin-Induced Thrombocytopenia</p> Signup and view all the answers

    Which of the following is a type of autonomous thrombocytosis (primary thrombocytosis)?

    <p>Essential Thrombocythemia</p> Signup and view all the answers

    What is the primary cause of Thrombotic Thrombocytopenic Purpura (TTP)?

    <p>Deficiency of ADAMTS13 enzyme</p> Signup and view all the answers

    Which of the following is a cause of reactive thrombocytosis (secondary thrombocytosis)?

    <p>Major surgery</p> Signup and view all the answers

    Which of the following is a genetic disorder associated with MYH9 gene mutations?

    <p>Fechtner syndrome</p> Signup and view all the answers

    What is the main characteristic of autonomous thrombocytosis (primary thrombocytosis)?

    <p>Marked increase in platelet count</p> Signup and view all the answers

    Which of the following conditions is characterized by skeletal defects such as long extremities and spider fingers?

    <p>Marfan's Syndrome</p> Signup and view all the answers

    In which condition are bruised areas commonly seen on the forearms of the elderly due to collagen degeneration?

    <p>Senile Purpura</p> Signup and view all the answers

    Which condition is most commonly seen in children and is characterized by gastrointestinal hemorrhage and joint swelling?

    <p>Henoch-Schonlein Purpura</p> Signup and view all the answers

    Which condition involves the adrenal glands and is characterized by severe capillary damage following meningococcal septicemia?

    <p>Waterhouse-Friedrichsen Syndrome</p> Signup and view all the answers

    Which condition is associated with tumors composed of vessels that commonly swell and bleed at the surface, leading to a localized consumptive coagulopathy and risk for disseminated intravascular coagulation (DIC)?

    <p>Kasabach-Merritt Syndrome</p> Signup and view all the answers

    Which condition is characterized by defects in the synthesis of collagen and hyaluronic acid due to a deficiency of ascorbic acid (vitamin C)?

    <p>Scurvy</p> Signup and view all the answers

    Which of the following is a characteristic of an acquired bleeding disorder?

    <p>Bleeding episodes begin after childhood</p> Signup and view all the answers

    What type of hemorrhage is characterized by systemic bleeding that appears as petechiae, purpura, or ecchymosis?

    <p>Mucocutaneous hemorrhage</p> Signup and view all the answers

    Which of the following is an indication of congenital hemorrhagic disorders?

    <p>Hemorrhage into joints, CNS, soft tissues &amp; peritoneum</p> Signup and view all the answers

    Which type of hemorrhage is seen in acquired or congenital defects in secondary hemostasis or plasma coagulopathies?

    <p>Soft tissue hemorrhage</p> Signup and view all the answers

    What is the prevalence of congenital bleeding disorders?

    <p>Occurring in fewer than 1/100 people</p> Signup and view all the answers

    Which of the following is a potential cause of the bleeding disorders described in the text?

    <p>Single/multiple coagulation factor deficiencies</p> Signup and view all the answers

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