Diphenoxylate with Atropine Flashcards

Created by

@WellBacklitJasmine

Study Notes

Drug Overview

Diphenoxylate with atropine is commercially known as Lomotil or Lonox.
Classifies as an anti-diarrheal and a phenylpiperidine derivative, functioning as an opiate agonist.

Dosage and Administration

Recommended dosage is 5 mg orally four times a day, adjusted according to patient response, not exceeding 8 tablets in 24 hours.
Administration should be limited to 48 hours, taken with food, and the tablets can be crushed and mixed with fluids for better absorption.
Route of administration is oral (PO).

Mechanism of Action

Works by inhibiting gastric motility through action on mucosal receptors that regulate peristalsis, leading to reduced bowel movements.

Indications for Use

Prescribed for acute, nonspecific diarrhea and for acute exacerbations of chronic functional diarrhea.

Major Side Effects

Central Nervous System: May cause dizziness, drowsiness, light-headedness, headache, fatigue, confusion, and insomnia.
Respiratory: Risk of respiratory depression.
Ears, Eyes, Nose, Throat: Possible blurred vision and burning sensation in the eyes.
Gastrointestinal: Can lead to paralytic ileus, toxic megacolon, nausea, vomiting, dry mouth, and epigastric distress.
Systemic Reactions: Serious risks include anaphylaxis and angioedema.

Contraindications

Not suitable for individuals with known hypersensitivity to the drug.
Contraindicated in cases of pseudomembranous colitis, hepatic disease, and in children.

Description

Test your knowledge on diphenoxylate with atropine, also known as Lomotil. This quiz covers its therapeutic class, dosage information, and route of administration. Perfect for pharmacy students and healthcare professionals looking to reinforce their understanding of this medication.