Questions and Answers
What is the generic and trade name for diphenoxylate with atropine?
What is the therapeutic class of diphenoxylate with atropine?
Anti-diarrhea
The dosage for diphenoxylate with atropine is _____ mg qid.
5
What is the maximum dosage of diphenoxylate with atropine in 24 hours?
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How does diphenoxylate with atropine work?
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What are the indications for the use of diphenoxylate with atropine? (Select all that apply)
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Match the following major side effects with their categories:
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Which of the following are contraindications for diphenoxylate with atropine? (Select all that apply)
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Study Notes
Drug Overview
- Diphenoxylate with atropine is commercially known as Lomotil or Lonox.
- Classifies as an anti-diarrheal and a phenylpiperidine derivative, functioning as an opiate agonist.
Dosage and Administration
- Recommended dosage is 5 mg orally four times a day, adjusted according to patient response, not exceeding 8 tablets in 24 hours.
- Administration should be limited to 48 hours, taken with food, and the tablets can be crushed and mixed with fluids for better absorption.
- Route of administration is oral (PO).
Mechanism of Action
- Works by inhibiting gastric motility through action on mucosal receptors that regulate peristalsis, leading to reduced bowel movements.
Indications for Use
- Prescribed for acute, nonspecific diarrhea and for acute exacerbations of chronic functional diarrhea.
Major Side Effects
- Central Nervous System: May cause dizziness, drowsiness, light-headedness, headache, fatigue, confusion, and insomnia.
- Respiratory: Risk of respiratory depression.
- Ears, Eyes, Nose, Throat: Possible blurred vision and burning sensation in the eyes.
- Gastrointestinal: Can lead to paralytic ileus, toxic megacolon, nausea, vomiting, dry mouth, and epigastric distress.
- Systemic Reactions: Serious risks include anaphylaxis and angioedema.
Contraindications
- Not suitable for individuals with known hypersensitivity to the drug.
- Contraindicated in cases of pseudomembranous colitis, hepatic disease, and in children.
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Description
Test your knowledge on diphenoxylate with atropine, also known as Lomotil. This quiz covers its therapeutic class, dosage information, and route of administration. Perfect for pharmacy students and healthcare professionals looking to reinforce their understanding of this medication.
