Diabetes Mellitus: Understanding the Disease
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Questions and Answers

What is the percentage of patients with the potential risk of developing the disease due to the combination of DR3+DR4 antigens?

  • 85%
  • 95% (correct)
  • 75%
  • 90%

What is the primary mechanism of B-cell death in autoimmune insulitis?

  • Necrosis
  • Autophagy
  • Apoptosis (correct)
  • Mitosis

What is the main link in the pathogenesis of type 1 diabetes mellitus?

  • Dysfunction of the other islet cell types
  • Defect in the immunological surveillance system
  • Inflammation in the islets of Langerhans (correct)
  • Genetic predisposition to autoimmune diseases

Which of the following genes are associated with type 1 diabetes mellitus?

<p>HLA genes B8 and B15 (D)</p> Signup and view all the answers

What is the role of T lymphocytes in the development of type 1 diabetes mellitus?

<p>Initiation and development of the autoimmune process (B)</p> Signup and view all the answers

What is the normal ratio of insulin and C-peptide concentrations in blood and urine?

<p>1/3 (B)</p> Signup and view all the answers

What is the primary characteristic of diabetes mellitus?

<p>Hyperglycaemia due to insulin deficiency or impaired interaction (A)</p> Signup and view all the answers

Which of the following organs are particularly affected by chronic hyperglycaemia?

<p>Eyes, kidneys, nervous system, and cardiovascular system (A)</p> Signup and view all the answers

What is the primary cause of Type 1 diabetes mellitus?

<p>Absolute deficit in insulin secretion (A)</p> Signup and view all the answers

What is the term for the destruction of B-cells leading to absolute insulin deficiency?

<p>Immune-mediated diabetes (C)</p> Signup and view all the answers

What is the term for the acute life-threatening complication of diabetes characterized by hyperglycaemia and dehydration?

<p>Hyperosmolar coma without ketoacidosis (B)</p> Signup and view all the answers

How many groups of diabetes mellitus are distinguished by the modern classification of diabetes mellitus?

<p>4 (D)</p> Signup and view all the answers

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