Diabetes Mellitus Biochemistry Mind Map

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson
Download our mobile app to listen on the go
Get App

Questions and Answers

What is the effect of increased lipolysis in Diabetes Mellitus Type I?

  • Decreased blood ketone levels
  • Elevation of fatty acid levels (correct)
  • Increased production of triglycerides
  • Decreased glucose conversion to fat

What directly contributes to ketoacidosis in Diabetes Mellitus Type I?

  • High insulin levels
  • Decreased gluconeogenesis
  • Increased glycogen storage
  • Increased ketogenesis (correct)

Why does hyperglycemia occur in individuals with Diabetes Mellitus Type I?

  • Decreased insulin resistance
  • Increased glycolysis
  • Reduced glucose uptake by tissues (correct)
  • Decreased breakdown of fats

Which physiological change leads to dehydration in Diabetes Mellitus Type I?

<p>Polyuria due to high glucose levels (A)</p> Signup and view all the answers

What metabolic change is associated with high blood ketone levels?

<p>Increased proteolysis (A)</p> Signup and view all the answers

What potential complication arises from untreated hyperglycemia in Type I diabetes?

<p>Potential coma (C)</p> Signup and view all the answers

What effect does inadequate insulin production have on lipoprotein lipase?

<p>Decreased triglyceride clearance (C)</p> Signup and view all the answers

What is a primary consequence of increased gluconeogenesis in Diabetes Mellitus Type I?

<p>Elevated blood glucose levels (B)</p> Signup and view all the answers

The presence of glucose in urine is indicative of what underlying condition in Diabetes Mellitus Type I?

<p>Hyperglycemia (C)</p> Signup and view all the answers

What metabolic adaptation occurs due to lipolysis in Diabetes Mellitus Type I?

<p>Accumulation of ketone bodies (A)</p> Signup and view all the answers

What is the primary effect of insulin in relation to blood glucose levels?

<p>It enhances glucose uptake in tissues. (B)</p> Signup and view all the answers

Which condition is characterized by protein glycosylation leading to microvascular complications?

<p>Microvascular diseases. (D)</p> Signup and view all the answers

How does glucagon affect blood glucose levels?

<p>It stimulates glycogenolysis and gluconeogenesis. (D)</p> Signup and view all the answers

Which of the following describes Type II Diabetes Mellitus (NIDDM)?

<p>It is often linked to obesity. (C)</p> Signup and view all the answers

What role does sorbitol play in diabetic neuropathy?

<p>It leads to Schwann cell injury. (B)</p> Signup and view all the answers

Which of the following statements about the Oral Glucose Tolerance Test is correct?

<p>It assesses how well the body handles a glucose load. (C)</p> Signup and view all the answers

What describes the relationship between insulin and glycogen metabolism?

<p>Insulin activates pathways for glycogen synthesis and storage. (D)</p> Signup and view all the answers

What is a common pathophysiological effect observed in insulin deficiency?

<p>Increased proteolysis and elevated amino acids. (B)</p> Signup and view all the answers

Which of the following best describes the impact of chronic insulin elevation?

<p>Increased risks related to metabolic syndrome. (A)</p> Signup and view all the answers

Which hormone is primarily involved in increasing blood glucose levels?

<p>Glucagon. (C)</p> Signup and view all the answers

What happens to glucagon levels during fasting?

<p>They increase to mobilize energy. (D)</p> Signup and view all the answers

Which complication is least likely to occur in Type II Diabetes?

<p>Ketoacidosis. (C)</p> Signup and view all the answers

In the context of diabetes, what is glucosuria?

<p>Excess glucose in the urine. (C)</p> Signup and view all the answers

Flashcards

Diabetes Mellitus Type I (IDDM)

A condition where the body can't properly regulate blood sugar levels, leading to high blood sugar (hyperglycemia).

Lipolysis

The process by which the body breaks down stored fat for energy, releasing fatty acids into the bloodstream.

Ketogenesis

The production of ketone bodies, which are acidic compounds produced by the liver during periods of prolonged fasting or starvation - a by-product of lipolysis.

Ketoacidosis

A serious condition caused by a build-up of ketone bodies in the blood, making the blood more acidic.

Signup and view all the flashcards

Gluconeogenesis

The process by which the body uses amino acids (from proteins) to make glucose.

Signup and view all the flashcards

Proteolysis

The breakdown of protein into amino acids, often triggered by energy deficit.

Signup and view all the flashcards

Lipoprotein Lipase

An enzyme that breaks down triglycerides (fats) into fatty acids and glycerol.

Signup and view all the flashcards

Increase in Triglycerides

Increased levels of triglycerides in the blood, often associated with insulin deficiency as the body cannot process fat effectively.

Signup and view all the flashcards

Polyuria

The excretion of large amounts of urine, often a symptom of high blood sugar.

Signup and view all the flashcards

Dehydration and Electrolyte Loss

The loss of fluids and electrolytes (such as sodium, potassium, and chloride) from the body, often due to excessive urination.

Signup and view all the flashcards

Insulin Resistance

A state of impaired glucose utilization in the body, specifically in muscle and fat tissues. Insulin, the hormone responsible for regulating blood glucose levels, is present but its effects are diminished.

Signup and view all the flashcards

Microvascular Diseases

The long-term complications of diabetes that primarily affect the small blood vessels. It includes conditions like retinopathy (damage to the eyes) and nephropathy (damage to the kidneys).

Signup and view all the flashcards

Glycosuria

A condition characterized by excessive glucose in the urine, often a symptom of diabetes mellitus. High blood sugar levels exceed the kidneys' reabsorption capacity.

Signup and view all the flashcards

Diabetes Mellitus

A metabolic disorder affecting the body's ability to regulate blood sugar levels. This can lead to excessive glucose in the bloodstream (hyperglycemia).

Signup and view all the flashcards

Type I Diabetes (IDDM)

The specific type of diabetes resulting from the autoimmune destruction of pancreatic beta cells, which are responsible for producing insulin. This leads to an absolute lack of insulin.

Signup and view all the flashcards

Type II Diabetes (NIDDM)

The form of diabetes that arises primarily from insulin resistance. The body produces insulin but its cells become unresponsive to its effects, leading to high blood glucose levels. Often associated with obesity and older age.

Signup and view all the flashcards

Oral Glucose Tolerance Test

A medical test used to diagnose diabetes. It involves measuring blood glucose levels after fasting overnight and then again after consuming a specific amount of glucose. The test helps evaluate how well the body processes glucose.

Signup and view all the flashcards

Glucagon

Hormone that raises blood glucose levels. It stimulates the release of glucose from glycogen stores in the liver (glycogenolysis) and also promotes the production of new glucose (gluconeogenesis).

Signup and view all the flashcards

Glycogenolysis

Breakdown of glycogen, a stored form of glucose, into glucose, releasing it into the bloodstream.

Signup and view all the flashcards

Insulin

The hormone responsible for lowering blood glucose levels. It enhances glucose entry into cells, promotes glycogen synthesis, and suppresses gluconeogenesis.

Signup and view all the flashcards

Study Notes

Diabetes Mellitus Biochemistry Mind Map

  • Glucose Homeostasis: A balance between glucose production and glucose utilization. Insulin and glucagon play key roles, with insulin lowering blood glucose and glucagon raising it.
  • Insulin's Actions: Stimulates glycogen storage, enhances glucose uptake by tissues, and promotes glycogenolysis and gluconeogenesis. Inhibits ketogenesis and protein breakdown. Insulin also facilitates ion (K+, PO4-3-) absorption.
  • Glucagon's Actions: Stimulates glycogenolysis and gluconeogenesis, increases catabolic states, leading to elevated glucose and amino acid blood levels.
  • Chronic Insulin Elevation Effects: Associated with hypertension risk.
  • Oral Glucose Tolerance Test (OGTT): A diagnostic test assessing how well the body manages a glucose load. Abnormal responses indicate potential diabetes. Diabetic patients show prolonged elevated blood glucose levels after glucose administration.
  • Types of Diabetes:
    • Type I Diabetes Mellitus (IDDM): Insulin-dependent, autoimmune destruction of pancreatic beta cells. Typically onset at a young age. Requires insulin injections.
    • Type II Diabetes Mellitus (NIDDM): Non-insulin dependent, insulin resistance, often linked to obesity. Onset is usually in older age. Managed with diet, exercise, and hypoglycemic agents, with some functional insulin present, but cells resist its effects leading to reduced glucose utilization in peripheral tissues.
  • Metabolic Alterations in IDDM: Lack of insulin leads to high blood glucose and ketone bodies.
  • Metabolic Alterations in NIDDM: Insulin resistance, but no severe lipolysis or ketoacidosis
  • Hyperglycemia Effects: Increased blood glucose, glycosuria (glucose in urine), dehydration, electrolyte loss, and hypertriglyceridemia.
  • Macrovascular Diseases: Large vessel disease includes gangrene, ulcers, and atherosclerosis.
  • Microvascular Diseases: Capillary membrane changes (protein glycosylation) leading to retinopathy and nephropathy and sorbitol accumulation.
  • Neuropathies: Abnormal glucose metabolism in nerve cells, sorbitol accumulation, Schwann cell injury.
  • Renal Failure: Results from high glomerular filtration rates and sorbitol accumulation.
  • Diabetes Treatment: Insulin injections, diet modifications (low fat, high fiber), oral medications to improve insulin sensitivity and secretion.
  • Long-Term Complications: Retinopathy, nephropathy, macrovascular diseases, neuropathies, and renal failure.
  • Complications: Ketoacidosis, hypoglycemia (low blood glucose)
  • IDDM Treatment: Insulin injections. Careful monitoring of glucose level.
  • NIDDM Treatments: Diet adjustments, exercise, hypoglycemic agents, and insulin.
  • Glucose Utilization IDDM vs NIDDM: IDDM leads to high blood glucose and ketone bodies, NIDDM shows insulin resistance, and few, or no symptoms of ketoacidosis.

Studying That Suits You

Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

Quiz Team

Related Documents

More Like This

Use Quizgecko on...
Browser
Browser