Podcast
Questions and Answers
What is the effect of increased lipolysis in Diabetes Mellitus Type I?
What is the effect of increased lipolysis in Diabetes Mellitus Type I?
- Decreased blood ketone levels
- Elevation of fatty acid levels (correct)
- Increased production of triglycerides
- Decreased glucose conversion to fat
What directly contributes to ketoacidosis in Diabetes Mellitus Type I?
What directly contributes to ketoacidosis in Diabetes Mellitus Type I?
- High insulin levels
- Decreased gluconeogenesis
- Increased glycogen storage
- Increased ketogenesis (correct)
Why does hyperglycemia occur in individuals with Diabetes Mellitus Type I?
Why does hyperglycemia occur in individuals with Diabetes Mellitus Type I?
- Decreased insulin resistance
- Increased glycolysis
- Reduced glucose uptake by tissues (correct)
- Decreased breakdown of fats
Which physiological change leads to dehydration in Diabetes Mellitus Type I?
Which physiological change leads to dehydration in Diabetes Mellitus Type I?
What metabolic change is associated with high blood ketone levels?
What metabolic change is associated with high blood ketone levels?
What potential complication arises from untreated hyperglycemia in Type I diabetes?
What potential complication arises from untreated hyperglycemia in Type I diabetes?
What effect does inadequate insulin production have on lipoprotein lipase?
What effect does inadequate insulin production have on lipoprotein lipase?
What is a primary consequence of increased gluconeogenesis in Diabetes Mellitus Type I?
What is a primary consequence of increased gluconeogenesis in Diabetes Mellitus Type I?
The presence of glucose in urine is indicative of what underlying condition in Diabetes Mellitus Type I?
The presence of glucose in urine is indicative of what underlying condition in Diabetes Mellitus Type I?
What metabolic adaptation occurs due to lipolysis in Diabetes Mellitus Type I?
What metabolic adaptation occurs due to lipolysis in Diabetes Mellitus Type I?
What is the primary effect of insulin in relation to blood glucose levels?
What is the primary effect of insulin in relation to blood glucose levels?
Which condition is characterized by protein glycosylation leading to microvascular complications?
Which condition is characterized by protein glycosylation leading to microvascular complications?
How does glucagon affect blood glucose levels?
How does glucagon affect blood glucose levels?
Which of the following describes Type II Diabetes Mellitus (NIDDM)?
Which of the following describes Type II Diabetes Mellitus (NIDDM)?
What role does sorbitol play in diabetic neuropathy?
What role does sorbitol play in diabetic neuropathy?
Which of the following statements about the Oral Glucose Tolerance Test is correct?
Which of the following statements about the Oral Glucose Tolerance Test is correct?
What describes the relationship between insulin and glycogen metabolism?
What describes the relationship between insulin and glycogen metabolism?
What is a common pathophysiological effect observed in insulin deficiency?
What is a common pathophysiological effect observed in insulin deficiency?
Which of the following best describes the impact of chronic insulin elevation?
Which of the following best describes the impact of chronic insulin elevation?
Which hormone is primarily involved in increasing blood glucose levels?
Which hormone is primarily involved in increasing blood glucose levels?
What happens to glucagon levels during fasting?
What happens to glucagon levels during fasting?
Which complication is least likely to occur in Type II Diabetes?
Which complication is least likely to occur in Type II Diabetes?
In the context of diabetes, what is glucosuria?
In the context of diabetes, what is glucosuria?
Flashcards
Diabetes Mellitus Type I (IDDM)
Diabetes Mellitus Type I (IDDM)
A condition where the body can't properly regulate blood sugar levels, leading to high blood sugar (hyperglycemia).
Lipolysis
Lipolysis
The process by which the body breaks down stored fat for energy, releasing fatty acids into the bloodstream.
Ketogenesis
Ketogenesis
The production of ketone bodies, which are acidic compounds produced by the liver during periods of prolonged fasting or starvation - a by-product of lipolysis.
Ketoacidosis
Ketoacidosis
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Gluconeogenesis
Gluconeogenesis
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Proteolysis
Proteolysis
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Lipoprotein Lipase
Lipoprotein Lipase
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Increase in Triglycerides
Increase in Triglycerides
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Polyuria
Polyuria
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Dehydration and Electrolyte Loss
Dehydration and Electrolyte Loss
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Insulin Resistance
Insulin Resistance
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Microvascular Diseases
Microvascular Diseases
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Glycosuria
Glycosuria
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Diabetes Mellitus
Diabetes Mellitus
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Type I Diabetes (IDDM)
Type I Diabetes (IDDM)
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Type II Diabetes (NIDDM)
Type II Diabetes (NIDDM)
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Oral Glucose Tolerance Test
Oral Glucose Tolerance Test
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Glucagon
Glucagon
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Glycogenolysis
Glycogenolysis
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Insulin
Insulin
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Study Notes
Diabetes Mellitus Biochemistry Mind Map
- Glucose Homeostasis: A balance between glucose production and glucose utilization. Insulin and glucagon play key roles, with insulin lowering blood glucose and glucagon raising it.
- Insulin's Actions: Stimulates glycogen storage, enhances glucose uptake by tissues, and promotes glycogenolysis and gluconeogenesis. Inhibits ketogenesis and protein breakdown. Insulin also facilitates ion (K+, PO4-3-) absorption.
- Glucagon's Actions: Stimulates glycogenolysis and gluconeogenesis, increases catabolic states, leading to elevated glucose and amino acid blood levels.
- Chronic Insulin Elevation Effects: Associated with hypertension risk.
- Oral Glucose Tolerance Test (OGTT): A diagnostic test assessing how well the body manages a glucose load. Abnormal responses indicate potential diabetes. Diabetic patients show prolonged elevated blood glucose levels after glucose administration.
- Types of Diabetes:
- Type I Diabetes Mellitus (IDDM): Insulin-dependent, autoimmune destruction of pancreatic beta cells. Typically onset at a young age. Requires insulin injections.
- Type II Diabetes Mellitus (NIDDM): Non-insulin dependent, insulin resistance, often linked to obesity. Onset is usually in older age. Managed with diet, exercise, and hypoglycemic agents, with some functional insulin present, but cells resist its effects leading to reduced glucose utilization in peripheral tissues.
- Metabolic Alterations in IDDM: Lack of insulin leads to high blood glucose and ketone bodies.
- Metabolic Alterations in NIDDM: Insulin resistance, but no severe lipolysis or ketoacidosis
- Hyperglycemia Effects: Increased blood glucose, glycosuria (glucose in urine), dehydration, electrolyte loss, and hypertriglyceridemia.
- Macrovascular Diseases: Large vessel disease includes gangrene, ulcers, and atherosclerosis.
- Microvascular Diseases: Capillary membrane changes (protein glycosylation) leading to retinopathy and nephropathy and sorbitol accumulation.
- Neuropathies: Abnormal glucose metabolism in nerve cells, sorbitol accumulation, Schwann cell injury.
- Renal Failure: Results from high glomerular filtration rates and sorbitol accumulation.
- Diabetes Treatment: Insulin injections, diet modifications (low fat, high fiber), oral medications to improve insulin sensitivity and secretion.
- Long-Term Complications: Retinopathy, nephropathy, macrovascular diseases, neuropathies, and renal failure.
- Complications: Ketoacidosis, hypoglycemia (low blood glucose)
- IDDM Treatment: Insulin injections. Careful monitoring of glucose level.
- NIDDM Treatments: Diet adjustments, exercise, hypoglycemic agents, and insulin.
- Glucose Utilization IDDM vs NIDDM: IDDM leads to high blood glucose and ketone bodies, NIDDM shows insulin resistance, and few, or no symptoms of ketoacidosis.
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