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What is the most common organism associated with Necrotizing Otitis Externa?
What is the most common organism associated with Necrotizing Otitis Externa?
Which of the following may be a complication of Necrotizing Otitis Externa?
Which of the following may be a complication of Necrotizing Otitis Externa?
Which of the following is NOT a clinical feature of Necrotizing Otitis Externa?
Which of the following is NOT a clinical feature of Necrotizing Otitis Externa?
In terms of treatment for Necrotizing Otitis Externa, what is the most appropriate course of action?
In terms of treatment for Necrotizing Otitis Externa, what is the most appropriate course of action?
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Based on the provided content, what percentage of Necrotizing Otitis Externa cases occur in diabetic patients?
Based on the provided content, what percentage of Necrotizing Otitis Externa cases occur in diabetic patients?
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What percentage of infection-related hospitalizations are associated with type 1 and type 2 diabetes mellitus?
What percentage of infection-related hospitalizations are associated with type 1 and type 2 diabetes mellitus?
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What is the most prevalent type of diabetes mellitus in Ireland?
What is the most prevalent type of diabetes mellitus in Ireland?
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What is the defining manifestation of diabetes mellitus?
What is the defining manifestation of diabetes mellitus?
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What is the mechanism behind type 1 diabetes mellitus?
What is the mechanism behind type 1 diabetes mellitus?
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What is the average age of diagnosis for type 2 diabetes mellitus in Ireland?
What is the average age of diagnosis for type 2 diabetes mellitus in Ireland?
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Which of the following is NOT a common infection associated with diabetes mellitus?
Which of the following is NOT a common infection associated with diabetes mellitus?
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What is a key characteristic of infections in people with diabetes mellitus?
What is a key characteristic of infections in people with diabetes mellitus?
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What is good evidence that can improve outcomes in people with diabetes mellitus?
What is good evidence that can improve outcomes in people with diabetes mellitus?
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In diabetic patients, what can lead to a weakened immune system and increased risk of infections?
In diabetic patients, what can lead to a weakened immune system and increased risk of infections?
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What key element of foot ulcer prevention focuses on educating individuals involved in the patient's care?
What key element of foot ulcer prevention focuses on educating individuals involved in the patient's care?
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Which of the following is NOT a suggested medical intervention to prevent foot ulcers in diabetic patients?
Which of the following is NOT a suggested medical intervention to prevent foot ulcers in diabetic patients?
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Which study suggests a potential beneficial effect of insulin on the immune system in diabetic patients?
Which study suggests a potential beneficial effect of insulin on the immune system in diabetic patients?
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What is the main reason why diabetic patients should get vaccinated against infections like COVID-19, influenza, and S. pneumoniae?
What is the main reason why diabetic patients should get vaccinated against infections like COVID-19, influenza, and S. pneumoniae?
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Which areas of the foot are considered highest risk for ulceration?
Which areas of the foot are considered highest risk for ulceration?
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What does the acronym IWGDF stand for in the context of foot ulcer prevention?
What does the acronym IWGDF stand for in the context of foot ulcer prevention?
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What does the term 'offloading' refer to in the context of foot wound care?
What does the term 'offloading' refer to in the context of foot wound care?
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Which organism is NOT commonly associated with cellulitis in diabetic patients?
Which organism is NOT commonly associated with cellulitis in diabetic patients?
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What is a key treatment component for Fournier Gangrene?
What is a key treatment component for Fournier Gangrene?
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Which symptom is most characteristic of Necrotising Fasciitis?
Which symptom is most characteristic of Necrotising Fasciitis?
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For empiric treatment of cellulitis, what antibiotic is commonly started?
For empiric treatment of cellulitis, what antibiotic is commonly started?
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Which of the following is a clinical feature of Fournier Gangrene?
Which of the following is a clinical feature of Fournier Gangrene?
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What antibiotic combination is recommended if group A strep is suspected?
What antibiotic combination is recommended if group A strep is suspected?
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Which clinical feature is NOT associated with rapidly progressive necrotizing fasciitis?
Which clinical feature is NOT associated with rapidly progressive necrotizing fasciitis?
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Which organism is most commonly associated with emphysematous cholecystitis?
Which organism is most commonly associated with emphysematous cholecystitis?
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What complication is least associated with chronic hepatitis C infection in type 2 diabetes patients?
What complication is least associated with chronic hepatitis C infection in type 2 diabetes patients?
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What is a notable clinical feature of both emphysematous cholecystitis and hepatitis?
What is a notable clinical feature of both emphysematous cholecystitis and hepatitis?
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Which statement about the treatment of mild emphysematous cholecystitis is correct?
Which statement about the treatment of mild emphysematous cholecystitis is correct?
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How does chronic hepatitis C infection impact type 2 diabetes outcomes?
How does chronic hepatitis C infection impact type 2 diabetes outcomes?
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What symptom would be least likely reported by a patient with emphysematous cholecystitis?
What symptom would be least likely reported by a patient with emphysematous cholecystitis?
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What is the recommended action regarding specimen collection in diabetic foot infections before starting antimicrobial therapy?
What is the recommended action regarding specimen collection in diabetic foot infections before starting antimicrobial therapy?
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Which specimen collection method is acceptable for diagnosing osteomyelitis?
Which specimen collection method is acceptable for diagnosing osteomyelitis?
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What is the best practice for urine sample collection when a delay of ≥4 hours is expected before laboratory transport?
What is the best practice for urine sample collection when a delay of ≥4 hours is expected before laboratory transport?
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In the clinical diagnosis of diabetic foot infections, which of the following is NOT a symptom or sign of inflammation to look for?
In the clinical diagnosis of diabetic foot infections, which of the following is NOT a symptom or sign of inflammation to look for?
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What should be included when sending specimens to microbiology for a diabetic foot infection?
What should be included when sending specimens to microbiology for a diabetic foot infection?
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Which approach is advised for starting empirical antimicrobial therapy for diabetic foot infections?
Which approach is advised for starting empirical antimicrobial therapy for diabetic foot infections?
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Which of the following describes the Probe to Bone test in relation to diabetic foot infections?
Which of the following describes the Probe to Bone test in relation to diabetic foot infections?
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What is the gold standard method for diagnosing bone involvement in diabetic foot infections?
What is the gold standard method for diagnosing bone involvement in diabetic foot infections?
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Flashcards
Diabetes Mellitus
Diabetes Mellitus
A condition where the body cannot regulate blood sugar levels properly due to inadequate insulin action.
Type 1 Diabetes Mellitus
Type 1 Diabetes Mellitus
Type of diabetes where the immune system mistakenly attacks and destroys insulin-producing cells in the pancreas, leading to a complete lack of insulin.
Type 2 Diabetes Mellitus
Type 2 Diabetes Mellitus
Type of diabetes caused by the body's inability to use insulin effectively, resulting in a relative deficiency.
Hyperglycemia
Hyperglycemia
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Diabetes and Infection
Diabetes and Infection
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Infections in Diabetes: Impact
Infections in Diabetes: Impact
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Hyperglycemia Management: Impact on Infections
Hyperglycemia Management: Impact on Infections
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Diabetes Mellitus: Risk of Infection
Diabetes Mellitus: Risk of Infection
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Cellulitis
Cellulitis
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Fournier Gangrene
Fournier Gangrene
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Necrotizing Fasciitis
Necrotizing Fasciitis
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Wound Infection
Wound Infection
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IV Vancomycin
IV Vancomycin
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Necrotizing Otitis Externa
Necrotizing Otitis Externa
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Pseudomonas aeruginosa
Pseudomonas aeruginosa
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Invasion of Surrounding Structures
Invasion of Surrounding Structures
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Intracranial Involvement
Intracranial Involvement
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Treatment for Necrotizing Otitis Externa
Treatment for Necrotizing Otitis Externa
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Healthy Diet and Immunity
Healthy Diet and Immunity
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Foot Self-Examination
Foot Self-Examination
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Proper Footwear
Proper Footwear
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Importance of Podiatrists
Importance of Podiatrists
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Wound Care
Wound Care
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Glucose Control
Glucose Control
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Managing Co-Existing Medical Conditions
Managing Co-Existing Medical Conditions
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Vaccines for Diabetes
Vaccines for Diabetes
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Necrotizing fasciitis caused by group A Streptococcus
Necrotizing fasciitis caused by group A Streptococcus
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Antibiotic treatment for group A Streptococcus necrotizing fasciitis
Antibiotic treatment for group A Streptococcus necrotizing fasciitis
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Hepatitis in Diabetes
Hepatitis in Diabetes
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Non-alcoholic fatty liver disease (NAFLD)
Non-alcoholic fatty liver disease (NAFLD)
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Emphysematous Cholecystitis
Emphysematous Cholecystitis
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Complications of Emphysematous Cholecystitis
Complications of Emphysematous Cholecystitis
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Clinical features of Emphysematous Cholecystitis
Clinical features of Emphysematous Cholecystitis
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Probe to bone test
Probe to bone test
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Midstream urine collection
Midstream urine collection
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Urine container with boric acid
Urine container with boric acid
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Tissue specimen for diabetic foot infection
Tissue specimen for diabetic foot infection
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Specimen collection and sensitivity testing
Specimen collection and sensitivity testing
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Clinical assessment of diabetic foot infection
Clinical assessment of diabetic foot infection
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Classic symptoms of diabetic foot infection
Classic symptoms of diabetic foot infection
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Choosing appropriate antibiotics for diabetic foot infection
Choosing appropriate antibiotics for diabetic foot infection
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Study Notes
Infections in People with Diabetes Mellitus
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Infections are more frequent, and individuals with diabetes mellitus have a poorer response to treatment leading to a more rapid progression to severe forms of infection.
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Type 1 and type 2 Diabetes Mellitus are associated with a high risk of infection.
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6% of infection-related hospitalizations and 12% of infection-related deaths are linked to diabetes.
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Strongest associations with bone and joint infections, sepsis, and cellulitis.
Diabetes Mellitus
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Diabetes mellitus is characterized by inadequate insulin action, leading to hyperglycemia.
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Type 1 diabetes mellitus is the result of autoimmune destruction of insulin-secreting cells, leading to an absolute deficiency of insulin.
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Type 2 diabetes mellitus is characterized by relative inadequacy of insulin action due to end-organ insulin resistance.
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In Ireland, 87.9% of diabetics have type 2 diabetes
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The average age of diagnosis for type 2 diabetes is between the 5th and 6th decade of life.
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Often, individuals with Type 2 Diabetes are asymptomatic.
Urinary Tract Infections (UTIs) in Diabetes
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Women with diabetes are almost twice more likely to experience UTIs than those without.
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Essential to conduct urine culture to diagnose UTIs.
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Do not treat asymptomatic bacteriuria.
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Treatment decisions should be based on local trends of antibiotic resistance.
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Complications include: incontinence, chronic prostatitis, staghorn urinary calculi, and pyelonephritis.
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Patients with DM have a higher risk of progression to bilateral pyelonephritis which is often more severe.
Pneumonia in Diabetes
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Patients with DM have higher rates of hospitalization and mortality with pneumonia.
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The most common organisms affecting individuals with diabetes are Streptococcus species (community-acquired) and Gram-negative anaerobes (aspiration pneumonia).
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For community-acquired pneumonia, calculate CURB-65 to determine appropriate antibiotic treatment.
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For healthcare-acquired pneumonia, antibiotic decisions should be guided by local antibiotic resistance trends.
Pneumonia: Clinical Features and Complications
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Clinical features include a productive cough (mucopurulent sputum), shortness of breath, pleuritic chest pain, fatigue, malaise, and fever.
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Complications may include empyema, pericarditis, respiratory failure, diabetic ketoacidosis, and sepsis.
Tuberculosis in Diabetes
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Patients with poorer glycaemic control have a higher risk of contracting tuberculosis.
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Patients with DM are also at higher risk of treatment failure in tuberculosis.
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Isoniazid is best taken with pyridoxine.
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Rifampin may cause hyperglycemia and increase the clearance of diabetic medications.
COVID-19 in Diabetes
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Diabetes is correlated with an increased risk of COVID-19 morbidity and mortality.
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Poorly-controlled diabetes is significantly correlated with increased mortality in both type 1 and type 2 diabetics.
Skin and Soft Tissue Infections (SSTIs) in Diabetes
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The most common organisms causing SSTIs in diabetes are Staph aureus, S. pyogenes and other streptococcal species.
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Empiric treatment (flucloxacillin for superficial ulcers and Co-amoxiclav/piperacillin-tazobactam for deep ulcers for example) is commonly used with adjustments based on specific cultures and susceptibilities.
Fournier Gangrene
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Anaerobic and aerobic bacteria, such as Staph aureus, Pseudomonas, and Clostridium perfringens are the common causative organisms for Fournier Gangrene.
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Debridement and broad-spectrum antibiotics are essential for treatment.
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Clinical features include infection of soft tissue and fascia, pain, fever, diarrhoea, dizziness, swelling, and a purplish rash.
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Necrosis and edema are frequently noted in the condition.
Necrotizing Fasciitis
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Severe infection, limb loss is more common with this condition.
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Group A Strep (Streptococcus pyogenes), often with other contributing organisms is typically the causative factor.
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Treatment involves surgical debridement.
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Empiric therapy with broad-spectrum antibiotics, targeting, for instance, vancomycin alongside piperacillin-tazobactam and clindamycin, is often administered.
Hepatitis in Diabetes
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Hepatitis C outcomes in individuals with type 2 diabetes are worse than in those without, with higher instances of cirrhosis and antiviral treatment failure.
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Chronic Hepatitis C is found significantly more in those with Type 2 Diabetes (T2DM)
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Chronic Hepatitis C sufferers with T2DM are more likely to suffer from cirrhosis.
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Clinical features include abdominal pain, nausea and vomiting, weakness and fatigue, and dark urine.
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Complications of Hepatitis C in diabetics include cirrhosis, malignancy, and fulminant liver failure.
Emphysematous Cholecystitis
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Approximately 50% of those with emphysematous cholecystitis have diabetes.
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The most common causative organisms are Clostridium perfringens, Klebsiella, and E. coli.
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Treatment is typically cholecystectomy; however, antibiotics may be considered in mild cases.
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Clinical features include nonspecific symptoms, fever, abdominal pain, and nausea/vomiting.
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Complications can include acute kidney injury (AKI), septic shock, and rarely, pneumomediastinum.
Necrotizing Otitis Externa
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Necrotizing otitis externa is 90% correlated with diabetes.
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The frequently identified pathogenic organism is Pseudomonas aeruginosa.
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Treatment involves systemic antibiotics with antipseudomonal activity in conjunction with local canal care, including cleaning and debridement.
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Clinical features include constant severe localized ear pain (typically worse at night), a foul-smelling purulent otorrhoea, headaches, and invasion of surrounding structures like the facial nerve, leading potentially to complications such as skull base osteomyelitis, intracranial involvement (leading to confusion,meningitis, or thrombosis), and death.
Onychomycosis
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Individuals with diabetes are twice as likely to develop onychomycosis.
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Onychomycosis is fungal infection affecting the toenails or fingernails.
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Diagnosis is via fungal culture and microscopy.
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Treatment typically involves oral antifungal agents.
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Clinical features include discolouration, subungal hyperkeratosis, onycholysis, and nail plate destruction.
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Complications include functional impairment and chronic pain.
Mucormycosis
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Mucormycosis is strongly associated with diabetes, with between 17% and 88% of cases occurring in individuals with DM.
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This infection is caused by various species of mucormycetes.
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A tissue biopsy is necessary for diagnosis, and imaging can assist in assessing the infection's extent.
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Debulking of infected areas plus antifungal therapy is essential as a treatment strategy.
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Clinical presentation typically includes acute sinusitis/headache, respiratory issues, and skin lesions.
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Sinuses are commonly involved in primary infections, with the cerebrum/orbits also being frequently affected early.
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The respiratory tract is a common secondary infection site and is often indicated by fever and haemoptysis.
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Skin infections are typically indicated by single, ulcerative, necrotic lesions accompanied by pain and inflammation.
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Further issues including lower abdominal pain and haematemesis may also manifest depending on the region and extent of infection.
Fungal Genitourinary Infections
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Risk of fungal genitourinary infections is heightened by the use of SGLT2 inhibitors and increased glucose concentration in urine.
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Candida species are frequently seen as the causative organism in these infections.
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Early treatment with fluconazole is a common first-line approach for symptomatic treatment.
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Complications include recurrence and candidaemia, particularly in immunocompromised patients.
Laboratory Diagnosis of Infections in Diabetes
- Laboratory diagnosis should be detailed. Specific procedures should be conducted depending on the area of infection and the patient's history.
Foot Infections in Diabetes
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Important to send appropriately obtained specimens to the Microbiology lab. Ideally this occurs before antibiotic treatment.
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Cleanse and debride the infected area before collecting wound samples.
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Collecting a sample from the base of the ulcer is the preferred technique rather than a superficial swab.
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The specimen is usually placed in saline and sent promptly to the lab.
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Essential to provide a detailed history for the specimen which emphasizes the causative factor is a diabetic foot infection, as well as details surrounding a Gram stain, culture and susceptibility testing.
Investigating Diabetic Foot Infections
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Blood cultures and other relevant cultures (urine, tissue, or bone) should be conducted, as well as a MRSA screen
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History of residential care and recent hospitalisation are relevant factors that should raise caution and suspicion.
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In cases of suspected osteomyelitis, imaging like CXR and X-rays of affected areas, or in cases where osteomyelitis isn't evident, MRI is commonly used when required.
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Vascular assessment is important and should include ankle brachial index, Doppler waveform, or transcutaneous oxygen tension determination, where feasible. Toe pressures are also commonly considered.
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Results obtained from these procedures should be viewed against the broader clinical context.
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If needed probe to bone test can be useful in diagnosing suspected osteomyelitis.
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A swab from an ulcer commonly will grow something—not necessarily indicating it is infected but further testing and consideration of all clinical factors are required.
Revised Guidelines on Diabetic Foot Infections (DFI) 2012
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Clinical diagnosis of DFI should incorporate systemic signs.
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Assessment of affected limb for risk factors is crucial.
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Presence of two of three classic symptoms/signs (inflammation or purulence) in the affected wound is considered a key diagnostic criterion.
Antimicrobial Treatment
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Treatment for mild or moderate infections typically involves empiric therapy— such as flucloxacillin— tailored for the specific clinical setting.
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Severe infections, or those with known or suspected resistant organisms, frequently necessitate intravenous treatments—such as flucloxacillin—in combination with other therapies where necessary to prevent or treat complications. Further treatments may be initiated after culture (including tissue/bone) has been conducted.
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Deep foot ulcers require anaerobic coverage and may involve co-amoxiclav or piperacillin-tazobactam intravenous treatment, possibly supplemented with vancomycin in cases with suspected MRSA or Pseudomonas infection.
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Osteomyelitis cases require empirical treatment with co-amoxiclav or piperacillin-tazobactam.
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Duration of treatment should be at least 28 days, but may be extended depending on factors including clinical presentation, extent of tissue involvement, and adequacy of debridement and vascular supply.
Prevention of Infections in Diabetes
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Maintaining a healthy lifestyle through physical activity, smoking cessation, good hygiene practices, and a balanced diet rich in fruits, vegetables, and whole grains to maintain a healthy immune system.
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Foot care, including self-inspection, correct footwear usage, and podiatrist visits, are vital preventative measures.
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Medical management includes optimized glucose control, management of other comorbidities, and vaccinations.
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Vaccination against infectious diseases such as COVID-19, influenza, and S. pneumoniae is essential.
Classification of Cellulitis Severity
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Mild cellulitis is localized to the skin and subcutaneous tissue.
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Moderate cellulitis encompasses symptoms of erythema around the ulcer with greater extent and further diagnostic criteria.
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Severe cellulitis is characterized by local infection signs and two indicative systemic criteria that are often associated with SIRS.
Determining Infection Severity
- Assessment of infection severity should be based on careful evaluation of clinical indicators.
General Principles for Antimicrobials in Cellulitis/Osteomyelitis
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Treatment for mild to moderate cases of infections should use Gram-positive cocci agents only unless risk factors for Pseudomonas are noted.
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Severe infections require broad-spectrum empiric therapy, necessitating close monitoring of results and possible urgent surgical consultation if there are significant signs such as the presence of gas in deeper tissues, necrotizing fasciitis, or abscesses.
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Description
Test your knowledge on Necrotizing Otitis Externa and its association with diabetes mellitus. This quiz covers various aspects including common organisms, complications, clinical features, and treatment options related to the condition. Additionally, explore the prevalence and characteristics of diabetes in relation to infections.