Development and Cancer: Causes and Genes
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Questions and Answers

What is the primary function of tumour suppressor genes?

  • To inhibit tumour formation by regulating cell growth (correct)
  • To stimulate angiogenesis
  • To induce apoptosis in healthy cells
  • To promote cell growth and division
  • What is the name of the gene that has been referred to as the 'guardian of the genome'?

  • FAS
  • p53 (correct)
  • pRb
  • RB
  • What is the term for the process by which cells that have acquired oncogenic mutations are removed?

  • Meiosis
  • Angiogenesis
  • Mitosis
  • Apoptosis (correct)
  • What is the name of the receptor that transmits death signals in response to apoptosis?

    <p>FAS receptor</p> Signup and view all the answers

    What is the term for the limited number of divisions a cell can undergo before reaching senescence?

    <p>Hayflick limit</p> Signup and view all the answers

    What is the purpose of angiogenesis in tumour development?

    <p>To bring blood flow and nutrients to tumours</p> Signup and view all the answers

    What is the term for the process by which cells become immortal due to the overexpression of telomerase?

    <p>Immortalization</p> Signup and view all the answers

    What is the term for the loss of a functional copy of a tumour suppressor gene, leading to the expression of a tumour-causing gene?

    <p>Loss of heterozygosity</p> Signup and view all the answers

    What is the term for genes that contribute to cancer in a gain-of-function manner and are dominant?

    <p>Oncogenes</p> Signup and view all the answers

    What is the name of the protein that monitors DNA damage and induces apoptosis in response to DNA damage?

    <p>p53</p> Signup and view all the answers

    Which factor contributes to one in three people developing cancer?

    <p>Inherited germ line mutations</p> Signup and view all the answers

    What is a common reason for developing breast cancer in individuals between the ages of 36 and 45?

    <p>Mutation in BRCA1 gene</p> Signup and view all the answers

    Which genetic mutations are associated with predisposition to cancer?

    <p>BRCA1, BRCA2, CDKN2A</p> Signup and view all the answers

    What is a common cancer associated with the Human papillomavirus (HPV)?

    <p>Cervical cancer</p> Signup and view all the answers

    Which characteristic is outlined as a hallmark of cancer in the text?

    <p>Insensitivity to growth-inhibitory signals</p> Signup and view all the answers

    What is recommended for individuals with BRCA mutations to minimize the risk of breast cancer?

    <p>Genetic counseling</p> Signup and view all the answers

    Which agent is associated with causing stomach cancer?

    <p>H.pylori bacteria</p> Signup and view all the answers

    What does the concept 'self-sufficiency in growth signals' refer to?

    <p>Cancer cells needing external growth signals</p> Signup and view all the answers

    Which condition is a potential consequence of sustained angiogenesis in cancer?

    <p>Tumor growth and metastasis</p> Signup and view all the answers

    What is the primary function of inherited cancer genes like Rb and p53?

    <p>Control cell growth and division</p> Signup and view all the answers

    What is the role of SHH as a morphogen?

    <p>Induces neural cell fate in the spinal cord</p> Signup and view all the answers

    What is the consequence of the inhibition of the SHH pathway by Cyclopanine?

    <p>Impaired pathway activation due to SMO binding</p> Signup and view all the answers

    Which gene is involved in cell adhesion?

    <p>Rac1</p> Signup and view all the answers

    What is the function of Smoothened in the Shh pathway?

    <p>Activates the pathway by binding to SHH ligand</p> Signup and view all the answers

    What is the result of a GOF mutation in the SHH pathway?

    <p>Increased cancer risk</p> Signup and view all the answers

    How does VEGf affect angiogenesis?

    <p>Promotes angiogenesis</p> Signup and view all the answers

    Which protein binds directly to SMO, inhibiting the SHH pathway?

    <p>Cyclopanine</p> Signup and view all the answers

    What is the main function of Gli transcription factors in the Shh pathway?

    <p>Leading to gene expression</p> Signup and view all the answers

    In the context of medulloblastoma, why do commissural neurons turn towards SHH gradients?

    <p>In response to SHH ligand concentrations</p> Signup and view all the answers

    Which condition is a result of a mutation in the SHH pathway leading to no pathway activity at all?

    <p>Holoprosencephaly</p> Signup and view all the answers

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