Podcast
Questions and Answers
What is the primary function of tumour suppressor genes?
What is the primary function of tumour suppressor genes?
- To inhibit tumour formation by regulating cell growth (correct)
- To stimulate angiogenesis
- To induce apoptosis in healthy cells
- To promote cell growth and division
What is the name of the gene that has been referred to as the 'guardian of the genome'?
What is the name of the gene that has been referred to as the 'guardian of the genome'?
- FAS
- p53 (correct)
- pRb
- RB
What is the term for the process by which cells that have acquired oncogenic mutations are removed?
What is the term for the process by which cells that have acquired oncogenic mutations are removed?
- Meiosis
- Angiogenesis
- Mitosis
- Apoptosis (correct)
What is the name of the receptor that transmits death signals in response to apoptosis?
What is the name of the receptor that transmits death signals in response to apoptosis?
What is the term for the limited number of divisions a cell can undergo before reaching senescence?
What is the term for the limited number of divisions a cell can undergo before reaching senescence?
What is the purpose of angiogenesis in tumour development?
What is the purpose of angiogenesis in tumour development?
What is the term for the process by which cells become immortal due to the overexpression of telomerase?
What is the term for the process by which cells become immortal due to the overexpression of telomerase?
What is the term for the loss of a functional copy of a tumour suppressor gene, leading to the expression of a tumour-causing gene?
What is the term for the loss of a functional copy of a tumour suppressor gene, leading to the expression of a tumour-causing gene?
What is the term for genes that contribute to cancer in a gain-of-function manner and are dominant?
What is the term for genes that contribute to cancer in a gain-of-function manner and are dominant?
What is the name of the protein that monitors DNA damage and induces apoptosis in response to DNA damage?
What is the name of the protein that monitors DNA damage and induces apoptosis in response to DNA damage?
Which factor contributes to one in three people developing cancer?
Which factor contributes to one in three people developing cancer?
What is a common reason for developing breast cancer in individuals between the ages of 36 and 45?
What is a common reason for developing breast cancer in individuals between the ages of 36 and 45?
Which genetic mutations are associated with predisposition to cancer?
Which genetic mutations are associated with predisposition to cancer?
What is a common cancer associated with the Human papillomavirus (HPV)?
What is a common cancer associated with the Human papillomavirus (HPV)?
Which characteristic is outlined as a hallmark of cancer in the text?
Which characteristic is outlined as a hallmark of cancer in the text?
What is recommended for individuals with BRCA mutations to minimize the risk of breast cancer?
What is recommended for individuals with BRCA mutations to minimize the risk of breast cancer?
Which agent is associated with causing stomach cancer?
Which agent is associated with causing stomach cancer?
What does the concept 'self-sufficiency in growth signals' refer to?
What does the concept 'self-sufficiency in growth signals' refer to?
Which condition is a potential consequence of sustained angiogenesis in cancer?
Which condition is a potential consequence of sustained angiogenesis in cancer?
What is the primary function of inherited cancer genes like Rb and p53?
What is the primary function of inherited cancer genes like Rb and p53?
What is the role of SHH as a morphogen?
What is the role of SHH as a morphogen?
What is the consequence of the inhibition of the SHH pathway by Cyclopanine?
What is the consequence of the inhibition of the SHH pathway by Cyclopanine?
Which gene is involved in cell adhesion?
Which gene is involved in cell adhesion?
What is the function of Smoothened in the Shh pathway?
What is the function of Smoothened in the Shh pathway?
What is the result of a GOF mutation in the SHH pathway?
What is the result of a GOF mutation in the SHH pathway?
How does VEGf affect angiogenesis?
How does VEGf affect angiogenesis?
Which protein binds directly to SMO, inhibiting the SHH pathway?
Which protein binds directly to SMO, inhibiting the SHH pathway?
What is the main function of Gli transcription factors in the Shh pathway?
What is the main function of Gli transcription factors in the Shh pathway?
In the context of medulloblastoma, why do commissural neurons turn towards SHH gradients?
In the context of medulloblastoma, why do commissural neurons turn towards SHH gradients?
Which condition is a result of a mutation in the SHH pathway leading to no pathway activity at all?
Which condition is a result of a mutation in the SHH pathway leading to no pathway activity at all?
