Podcast
Questions and Answers
What is the enzyme responsible for metabolizing alcohol in the body?
What is the enzyme responsible for metabolizing alcohol in the body?
- Acetaldehyde dehydrogenase
- Alcohol oxidase
- Aldehyde oxidase
- Alcohol dehydrogenase (correct)
Which type of cancers are directly attributed to alcohol consumption?
Which type of cancers are directly attributed to alcohol consumption?
- Skin cancers
- Oral cancers (correct)
- Breast cancers
- Brain cancers
In the classical model of cell division, how many daughter cells are produced?
In the classical model of cell division, how many daughter cells are produced?
- Four daughter stem cells
- One daughter stem cell and one lineage committed cell (correct)
- Two daughter stem cells
- Three lineage committed cells
What is the consequence of disruption in the granulocyte or monocyte lineage?
What is the consequence of disruption in the granulocyte or monocyte lineage?
Which specific chromosomal translocation is associated with Acute Promyelocytic Leukemia?
Which specific chromosomal translocation is associated with Acute Promyelocytic Leukemia?
How does the PML-RAR fusion oncoprotein induce leukemia?
How does the PML-RAR fusion oncoprotein induce leukemia?
How do IDH mutations in cancers affect gene expression?
How do IDH mutations in cancers affect gene expression?
What is the mechanism by which 2-hydroxyglutarate (2-HG) promotes apoptosis?
What is the mechanism by which 2-hydroxyglutarate (2-HG) promotes apoptosis?
How does folate deficiency contribute to tumor development?
How does folate deficiency contribute to tumor development?
What role does lactate play in promoting cancer aggressiveness?
What role does lactate play in promoting cancer aggressiveness?
How does 2-hydroxyglutarate (2-HG) affect collagen maturation?
How does 2-hydroxyglutarate (2-HG) affect collagen maturation?
What is the impact of lactate production on the tumor microenvironment?
What is the impact of lactate production on the tumor microenvironment?
Which type of T cells recognize antigens presented by class I MHC molecules?
Which type of T cells recognize antigens presented by class I MHC molecules?
Where are cytoplasmic proteins degraded into peptide fragments before they are presented by MHC class I molecules?
Where are cytoplasmic proteins degraded into peptide fragments before they are presented by MHC class I molecules?
Which immune cells mainly express MHC class II molecules for presenting antigens?
Which immune cells mainly express MHC class II molecules for presenting antigens?
What is the role of costimulatory signaling in T cell activation?
What is the role of costimulatory signaling in T cell activation?
Which organelle is involved in forming antigen complexes in the presentation of extracellular antigens?
Which organelle is involved in forming antigen complexes in the presentation of extracellular antigens?
What happens to T cells if they recognize an antigen but do not receive co-stimulation?
What happens to T cells if they recognize an antigen but do not receive co-stimulation?
What is a characteristic of EMT?
What is a characteristic of EMT?
How do tumor cells mainly cause MMP production?
How do tumor cells mainly cause MMP production?
What do secreted MMPs primarily do within tissues?
What do secreted MMPs primarily do within tissues?
What is the role of the CSF1/EGF paracrine loop in streaming migration during EMT?
What is the role of the CSF1/EGF paracrine loop in streaming migration during EMT?
How do tumor cells and macrophages migrate during streaming migration?
How do tumor cells and macrophages migrate during streaming migration?
What is the main purpose of immune checkpoint inhibitors in cancer therapy?
What is the main purpose of immune checkpoint inhibitors in cancer therapy?
Which type of therapy involves the adoptive transfer of naturally occurring T-cells found in a tumor?
Which type of therapy involves the adoptive transfer of naturally occurring T-cells found in a tumor?
Which immunotherapy approach involves expanding TILs ex vivo before transferring them back to patients?
Which immunotherapy approach involves expanding TILs ex vivo before transferring them back to patients?
What is the function of anti-PD-1 agents like pembrolizumab and nivolumab in cancer treatment?
What is the function of anti-PD-1 agents like pembrolizumab and nivolumab in cancer treatment?
Which molecule restrains tumor-infiltrating lymphocytes in the body?
Which molecule restrains tumor-infiltrating lymphocytes in the body?
Why is lymphodepletion treatment given to patients before transferring TILs back to them?
Why is lymphodepletion treatment given to patients before transferring TILs back to them?
