(Exam 2) Effects of Chronic Alcohol Consumption on DNA Mutations
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Questions and Answers

What is the enzyme responsible for metabolizing alcohol in the body?

  • Acetaldehyde dehydrogenase
  • Alcohol oxidase
  • Aldehyde oxidase
  • Alcohol dehydrogenase (correct)
  • Which type of cancers are directly attributed to alcohol consumption?

  • Skin cancers
  • Oral cancers (correct)
  • Breast cancers
  • Brain cancers
  • In the classical model of cell division, how many daughter cells are produced?

  • Four daughter stem cells
  • One daughter stem cell and one lineage committed cell (correct)
  • Two daughter stem cells
  • Three lineage committed cells
  • What is the consequence of disruption in the granulocyte or monocyte lineage?

    <p>Acute Myeloid Leukemia (AML)</p> Signup and view all the answers

    Which specific chromosomal translocation is associated with Acute Promyelocytic Leukemia?

    <p>t(15;17)</p> Signup and view all the answers

    How does the PML-RAR fusion oncoprotein induce leukemia?

    <p>By blocking normal myeloid differentiation</p> Signup and view all the answers

    How do IDH mutations in cancers affect gene expression?

    <p>Cause DNA hypomethylation</p> Signup and view all the answers

    What is the mechanism by which 2-hydroxyglutarate (2-HG) promotes apoptosis?

    <p>Inhibits cytochrome c oxidase</p> Signup and view all the answers

    How does folate deficiency contribute to tumor development?

    <p>Promotes DNA hypomethylation</p> Signup and view all the answers

    What role does lactate play in promoting cancer aggressiveness?

    <p>Causes extracellular acidification</p> Signup and view all the answers

    How does 2-hydroxyglutarate (2-HG) affect collagen maturation?

    <p>Inhibits prolyl hydroxylases</p> Signup and view all the answers

    What is the impact of lactate production on the tumor microenvironment?

    <p>Causes extracellular acidification</p> Signup and view all the answers

    Which type of T cells recognize antigens presented by class I MHC molecules?

    <p>CD8+ T-cells</p> Signup and view all the answers

    Where are cytoplasmic proteins degraded into peptide fragments before they are presented by MHC class I molecules?

    <p>Rough endoplasmic reticulum (RER)</p> Signup and view all the answers

    Which immune cells mainly express MHC class II molecules for presenting antigens?

    <p>Dendritic cells</p> Signup and view all the answers

    What is the role of costimulatory signaling in T cell activation?

    <p>Provides a second signal for full T cell activation</p> Signup and view all the answers

    Which organelle is involved in forming antigen complexes in the presentation of extracellular antigens?

    <p>Lysosomes</p> Signup and view all the answers

    What happens to T cells if they recognize an antigen but do not receive co-stimulation?

    <p>They remain inactive (anergy)</p> Signup and view all the answers

    What is a characteristic of EMT?

    <p>Increased expression of specific proteases</p> Signup and view all the answers

    How do tumor cells mainly cause MMP production?

    <p>By inducing stromal cells to produce MMPs</p> Signup and view all the answers

    What do secreted MMPs primarily do within tissues?

    <p>Create spaces for carcinoma cells to advance</p> Signup and view all the answers

    What is the role of the CSF1/EGF paracrine loop in streaming migration during EMT?

    <p>Unidirectional migration along collagen fibers</p> Signup and view all the answers

    How do tumor cells and macrophages migrate during streaming migration?

    <p>Utilizing a CSF1/EGF paracrine loop</p> Signup and view all the answers

    What is the main purpose of immune checkpoint inhibitors in cancer therapy?

    <p>To activate immune responses against tumors</p> Signup and view all the answers

    Which type of therapy involves the adoptive transfer of naturally occurring T-cells found in a tumor?

    <p>Tumor infiltrating lymphocyte (TIL) therapy</p> Signup and view all the answers

    Which immunotherapy approach involves expanding TILs ex vivo before transferring them back to patients?

    <p>TIL therapy</p> Signup and view all the answers

    What is the function of anti-PD-1 agents like pembrolizumab and nivolumab in cancer treatment?

    <p>Activating immune responses against tumors</p> Signup and view all the answers

    Which molecule restrains tumor-infiltrating lymphocytes in the body?

    <p>PD-1</p> Signup and view all the answers

    Why is lymphodepletion treatment given to patients before transferring TILs back to them?

    <p>To enhance the anti-tumor activity of transferred TILs</p> Signup and view all the answers

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