DNA Mutations and Cancer: Small-Scale Mutations
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Questions and Answers

What is the primary consequence of a frameshift mutation?

  • The translation process accelerates
  • The gene sequence remains intact
  • The reading frame is shifted, leading to incorrect codon parsing (correct)
  • The protein becomes longer

How are insertions and deletions related to frameshift mutations?

  • Insertions and deletions are unrelated to frameshift mutations
  • Insertions never lead to frameshift mutations
  • Deletions only cause frameshift mutations
  • Both insertions and deletions can result in frameshift mutations (correct)

What analogy is used to describe a deletion mutation?

  • Erasing a letter in a word (correct)
  • Adding punctuation to a sentence
  • Removing a stop sign from a sentence
  • Adding a word to a sentence

How does a nonsense mutation impact the translation process?

<p>Leads to a premature stop in translation (D)</p> Signup and view all the answers

Which type of mutation can result in a nonfunctional protein?

<p>Frameshift mutations (B)</p> Signup and view all the answers

How do insertions differ from deletions in terms of impact on genetic message reading frame?

<p>Insertions always cause frameshift mutations, while deletions do not (C)</p> Signup and view all the answers

What is the consequence of a frameshift mutation occurring near the end of a gene?

<p>The resulting protein is likely to be nonfunctional. (A)</p> Signup and view all the answers

In sickle-cell disease, which specific type of mutation affects the hemoglobin protein?

<p>Point mutation (B)</p> Signup and view all the answers

How do insertions and deletions outside of coding regions impact gene function?

<p>These changes still significantly influence how genes function. (B)</p> Signup and view all the answers

What happens when a specific point mutation in DNA results in the substitution of an adenine base with thymine?

<p>Alteration of the amino acid sequence in a protein (B)</p> Signup and view all the answers

How do missense mutations differ from nonsense mutations?

<p>Missense mutations alter one amino acid in a protein. (D)</p> Signup and view all the answers

Which of the following best describes the consequences of extensive missense mutations?

<p>Amino acids are substituted in the protein. (B)</p> Signup and view all the answers

What type of mutation involves adding or removing nucleotide pairs, like editing a sentence by adding or deleting words?

<p>Insertions and Deletions (D)</p> Signup and view all the answers

Which type of small-scale mutation is described as changing a single nucleotide pair, similar to swapping a single letter in a word?

<p>Substitutions (B)</p> Signup and view all the answers

A substitution mutation that changes 3′@CCG@5′ to 3′@CCA@5′ results in what mRNA codon after the change?

<p>GGU (C)</p> Signup and view all the answers

Which type of mutation does not change the protein's appearance and can sometimes occur outside genes as well?

<p>Silent Mutations (C)</p> Signup and view all the answers

A missense mutation is characterized by what change in the protein?

<p>Replacement of one amino acid with another (C)</p> Signup and view all the answers

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