Podcast
Questions and Answers
What is the main biological function of DNA topoisomerases?
What is the main biological function of DNA topoisomerases?
- Enhance DNA supercoiling
- Synthesize new DNA strands
- Repair damaged DNA strands
- Cleave both strands of double-stranded DNA simultaneously (correct)
In the context of cancer drug development, what role do topoisomerases play?
In the context of cancer drug development, what role do topoisomerases play?
- They induce apoptosis in cancer cells
- They repair damaged DNA in cancer cells
- They are targets for anticancer drug development (correct)
- They prevent cancer cell growth
How do Teniposide and etoposide relate to the mayapple plant?
How do Teniposide and etoposide relate to the mayapple plant?
- They are used as fertilizers for the mayapple plant
- They are toxins found in the mayapple plant
- They are developed from the main constituent of the mayapple plant (correct)
- They inhibit growth of the mayapple plant
What is the initial segment that Topoisomerase II binds before cleaving both DNA strands?
What is the initial segment that Topoisomerase II binds before cleaving both DNA strands?
What happens after the ATP binds to the two N-terminal domains of Topoisomerase II?
What happens after the ATP binds to the two N-terminal domains of Topoisomerase II?
How does Topoisomerase II reset after hydrolysis of ATP?
How does Topoisomerase II reset after hydrolysis of ATP?
What is the major mechanism of antineoplastic action of podophylotoxins?
What is the major mechanism of antineoplastic action of podophylotoxins?
Which isoform of topoisomerase II has two DNA independent binding sites?
Which isoform of topoisomerase II has two DNA independent binding sites?
What is the main difference between etoposide and teniposide?
What is the main difference between etoposide and teniposide?
What is the purpose of solubility enhancers in IV formulations of topoisomerase II inhibitors?
What is the purpose of solubility enhancers in IV formulations of topoisomerase II inhibitors?
When do topoisomerase II inhibitors have the most devastating effect on cells?
When do topoisomerase II inhibitors have the most devastating effect on cells?
What is the role of podophylotoxins in interacting with Topo IIα?
What is the role of podophylotoxins in interacting with Topo IIα?
