26 Questions
What are the drawbacks of the traditional 'one variable at a time' strategy for optimizing cement properties?
The traditional strategy often induces trade-offs in properties.
What specific needs and preferences are not accounted for in the available C3S cement kits?
Patients’ specific needs and clinicians’ preferences regarding setting time, radiopacity, mechanical, and handling properties.
How do slight variations in powder components and liquid content affect the properties of C3S cements?
Slight variations affect the cement’s properties and bioactivity.
What is the main issue with the currently available C3S cement kits for precision endodontics?
They do not account for patients’ specific needs or clinicians’ preferences.
Why is it virtually impossible to optimize several cement properties simultaneously via the traditional strategy?
Inputs often induce trade-offs in properties.
What is the focus of the research mentioned in the text?
Designing C3S cements with on-demand properties for precision endodontics.
How does a higher water-to-powder ratio affect flowability and mechanical properties of the cement?
Increases flowability but decreases mechanical properties
What approach involves offering the cement in predosed capsules with a predetermined W/P?
Standardized method
How do minor variations in the water-to-powder ratio affect the cement's handling, flowability, mechanical strength, and setting time?
Change
What raw powder composition affects the initial mechanical strength and modulates environmental alkalinity of the cement?
Tricalcium silicate (C3S)
Which component changes the setting time, alkalinity, and compressive strength of the cement?
Hepta-aluminate (C12A7)
What controls and shortens the setting time of the cement?
Calcium sulfate (CaSO4) and lithium carbonate (Li2CO3)
Which component changes the cement's radiopacity?
Zirconium dioxide (ZrO2)
What method was used to simultaneously analyze the effect of multiple inputs on setting time, pH, flowability, diametral tensile strength, and radiopacity of the cements?
Taguchi’s methods and genetic algorithms (GAs)
What did the authors show regarding the cements designed with genetic algorithms?
The results matched the predictions
What did the authors demonstrate regarding the cements' effect on genetic expression and differentiation potential of dental pulp stem cells?
Increased the genetic expression of odonto/osteogenic genes, alkaline phosphatase activity, and mineralization potential
What are the drawbacks of the traditional strategy for optimizing cement properties?
The traditional 'one variable at a time' strategy induces trade-offs in properties.
How do slight variations in powder components and liquid content affect C3S cements?
Slight variations in powder components and liquid content affect the cement's properties and bioactivity.
What did the authors demonstrate regarding the effect of cements on genetic expression and differentiation potential of dental pulp stem cells?
The authors demonstrated the effect of cements on genetic expression and differentiation potential of dental pulp stem cells.
Why is it virtually impossible to optimize several cement properties simultaneously via the traditional strategy?
Inputs often induce trade-offs in properties, making it virtually impossible to optimize several cement properties simultaneously.
What method was used to simultaneously analyze the effect of multiple inputs on setting time, pH, flowability, diametral tensile strength, and radiopacity of the cements?
Genetic algorithms were used to simultaneously analyze the effect of multiple inputs on the properties of the cements.
What method was used to analyze the effect of multiple inputs on setting time, pH, flowability, diametral tensile strength, and radiopacity of the cements?
Taguchi’s methods and genetic algorithms (GAs)
Which component changes the cement's radiopacity?
Zirconium dioxide (ZrO2)
What did the authors demonstrate regarding the cements' effect on genetic expression and differentiation potential of dental pulp stem cells?
Increased genetic expression of odonto/osteogenic genes, alkaline phosphatase activity, and mineralization potential of dental pulp stem cells
What raw powder composition affects the initial mechanical strength and modulates environmental alkalinity of the cement?
Tricalcium silicate (Ca3O5Si or simply C3S)
What controls and shortens the setting time of the cement?
Calcium sulfate (CaSO4) and lithium carbonate (Li2CO3)
Explore the research article about designing Calcium Silicate Cements with on-demand properties for precision endodontics. Learn about the latest developments in biomaterials and bioengineering for dental applications.
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