60 Questions
Which condition is characterized by superficial blisters in the epidermis with a fragile roof that sloughs off easily?
Pemphigus vulgaris
What is a common distribution pattern for immunobullous diseases?
Widespread eruptions with mucous membrane involvement
What can result in the traumatic removal of blister roofs, potentially confusing the clinical picture?
Scratching
Which condition may precede bullous pemphigoid?
Eczema
A tingling sensation may herald the onset of which condition?
Herpes simplex
Which type of blisters usually have a stronger roof and remain intact?
Subepidermal blisters
Which type of blisters have great structural integrity and can remain intact even when firmly compressed?
Sub-epidermal blisters
In which type of blisters does Desmoglein 1 have higher concentration in the skin?
Sub-corneal blisters
Which Desmoglein is more prominent in the lower epidermis of mucous membranes?
Desmoglein 3
Which of the following is a possible trigger for the production of skin-damaging autoantibodies in some patients?
Viral infections
What is the main cause of autoimmune blistering diseases according to the text?
Impaired adhesion of epidermal cells mediated by our immune system
Which of the following drugs is mentioned in the text as a possible trigger for autoimmune disorders?
Rifampicin
What is a common symptom of Pemphigoid Gestationis?
Painless papules and plaques
In Pemphigoid Gestationis, where do the cutaneous lesions predominantly occur?
Around the periumbilical area
What is a potential consequence of scalp involvement in Mucous Membrane Pemphigoid?
Scarring alopecia
Why should caution be taken if mothers with Pemphigoid Gestationis are breastfeeding?
Due to high doses of systemic corticosteroids in treatment
Which condition presents with more mucosal involvement and less skin involvement?
Cicatricial Pemphigoid
What is a potential ocular complication of Mucous Membrane Pemphigoid?
Dry eyes
What is the main cause of blister formation in autoimmune blistering conditions?
Edema between epidermal cells
Which condition is characterized by deep, tense blisters with intact skin?
Pemphigoid
In autoimmune blistering conditions, where does the loss of adhesion occur?
Within the epidermis
Which type of blisters in pemphigus are characterized as fragile and flaccid?
Superficial blisters
What is the characteristic appearance of epidermal cells in conditions leading to spongiosis and vesicle formation?
More intact blisters, less erosions
In autoimmune blistering conditions, what leads to the formation of vesicles between epidermal cells?
Edema
Which autoimmune blistering skin disease is associated with neurologic diseases such as cerebrovascular disease and Multiple Sclerosis?
Bullous Pemphigoid
Which protein complex links the cytoskeleton of the basal keratinocyte to the dermis?
Hemidesmosome
What is the most common autoimmune blistering skin disease?
Bullous Pemphigoid
Which type of deposits are seen at the dermo-epidermal junction in diseases of hemidesmosomes?
IgG
What is the potential trigger for Bullous Pemphigoid among the following?
Antibiotics
'Tense blisters and erosions on a background of dermatitis or normal skin' typically describe the presentation of which condition?
Bullous Pemphigoid
What is a potential consequence of scratching in autoimmune blistering conditions?
Traumatic removal of blister roofs
Which of the following skin conditions is characterized by superficial blisters in the epidermis with a fragile roof that sloughs off easily?
Pemphigus
Which type of deposits are seen at the dermo-epidermal junction in diseases affecting hemidesmosomes?
Subepidermal deposits
What is a common distribution pattern for herpes infections on the body?
Localized to lips, genitals, or dermatomes
In terms of durability, which condition presents with blisters that usually remain intact and have a stronger roof?
Bullous pemphigoid
What symptom can be an indicator of eczema preceding the development of bullous pemphigoid?
Pruritic lesions
Which type of blisters has a thicker roof and is more substantial, as described in the text?
Intra-epidermal blisters
In autoimmune blistering diseases, what can be inherited according to the text?
Susceptibility to develop autoimmune disorders
Which condition is characterized by impaired adhesion of epidermal cells to each other or to the epidermal basement membrane mediated by the immune system?
Autoimmune blistering diseases
Which Desmoglein is more prevalent in the lower epidermis of mucous membranes?
Desmoglein 3
What is a possible trigger for the production of skin-damaging autoantibodies in some patients according to the text?
Hormones
Which type of blisters have very thin roofs with little structural integrity that easily collapse?
Sub-corneal blisters
Which autoimmune blistering condition results from autoantibodies targeting desmoglein 1?
Pemphigus Vulgaris
In which type of pemphigoid does subcorneal split lead to rapidly and easily rupturing bullae?
Localized/Cicatricial/Mucous membrane pemphigoid
Which autoimmune blistering condition is associated with Neurologic diseases like cerebrovascular disease and Multiple Sclerosis?
Bullous Pemphigoid
Which autoimmune blistering condition is characterized by deep, tense bullae with less erosions?
Para-neoplastic pemphigus
Which protein complex is targeted by autoantibodies in Bullous Pemphigoid?
BP180
Which type of blistering disease typically presents with more mucosal involvement and less skin involvement?
Pemphigoid Gestationis
What is the main cause of blister formation in autoimmune blistering conditions according to the text?
Edema between epidermal cells
In autoimmune blistering conditions, where does the loss of adhesion occur?
Within the epidermis or at the basement membrane
What is a potential consequence of scalp involvement in Mucous Membrane Pemphigoid?
Increased risk of ocular complications
Where do cutaneous lesions predominantly occur in Pemphigoid Gestationis?
Perioral area and trunk
Which of the following drugs is mentioned in the text as a possible trigger for autoimmune disorders?
Immunosuppressants
'Tense blisters and erosions on a background of dermatitis or normal skin' typically describe the presentation of which condition?
Dermatitis Herpetiformis
Which autoimmune blistering disease is characterized by circulating IgG and basement membrane zone–bound IgG antibodies?
Bullous Pemphigoid
Which protein complex is involved in linking the cytoskeleton of the basal keratinocyte to the dermis?
Hemidesmosome
What is the potential trigger for Bullous Pemphigoid among the following?
UV radiation
Which autoimmune blistering skin disease is associated with neurologic diseases like cerebrovascular disease?
Bullous Pemphigoid
What type of blisters does Bullous Pemphigoid typically present with?
Tense blisters and erosions on a background of dermatitis or normal skin
Where are linear deposits of IgG, C3, or IgA seen in autoimmune sub-epidermal blistering diseases?
At the dermo-epidermal junction
Test your knowledge by matching the given dermatological symptoms with their corresponding causes and conditions such as chicken pox, hand foot mouth disease, herpes simplex, herpes zoster, DH, pompholyx eczema, bullous pemphigoid, and more. Identify the correct relationships to assess your understanding of dermatological conditions.
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