Blistering Disorders

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Which condition is characterized by superficial blisters in the epidermis with a fragile roof that sloughs off easily?

Herpes simplex virus

Toxic epidermal necrolysis

Stevens-Johnson syndrome

Pemphigus vulgaris (correct)

What is a common distribution pattern for immunobullous diseases?

Involve sun-exposed skin

Localized to lips or dermatomes

Remain intact and are subepidermal

Widespread eruptions with mucous membrane involvement (correct)

What can result in the traumatic removal of blister roofs, potentially confusing the clinical picture?

Linear IgA

Epidermolysis bullosa

Porphyria cutanea tarda

Scratching (correct)

Which condition may precede bullous pemphigoid?

Eczema Signup and view all the answers

A tingling sensation may herald the onset of which condition?

Herpes simplex Signup and view all the answers

Which type of blisters usually have a stronger roof and remain intact?

Subepidermal blisters Signup and view all the answers

Which type of blisters have great structural integrity and can remain intact even when firmly compressed?

Sub-epidermal blisters Signup and view all the answers

In which type of blisters does Desmoglein 1 have higher concentration in the skin?

Sub-corneal blisters Signup and view all the answers

Which Desmoglein is more prominent in the lower epidermis of mucous membranes?

Desmoglein 3 Signup and view all the answers

Which of the following is a possible trigger for the production of skin-damaging autoantibodies in some patients?

Viral infections Signup and view all the answers

What is the main cause of autoimmune blistering diseases according to the text?

Impaired adhesion of epidermal cells mediated by our immune system Signup and view all the answers

Which of the following drugs is mentioned in the text as a possible trigger for autoimmune disorders?

Rifampicin Signup and view all the answers

What is a common symptom of Pemphigoid Gestationis?

Painless papules and plaques Signup and view all the answers

In Pemphigoid Gestationis, where do the cutaneous lesions predominantly occur?

Around the periumbilical area Signup and view all the answers

What is a potential consequence of scalp involvement in Mucous Membrane Pemphigoid?

Scarring alopecia Signup and view all the answers

Why should caution be taken if mothers with Pemphigoid Gestationis are breastfeeding?

Due to high doses of systemic corticosteroids in treatment Signup and view all the answers

Which condition presents with more mucosal involvement and less skin involvement?

Cicatricial Pemphigoid Signup and view all the answers

What is a potential ocular complication of Mucous Membrane Pemphigoid?

Dry eyes Signup and view all the answers

What is the main cause of blister formation in autoimmune blistering conditions?

Edema between epidermal cells Signup and view all the answers

Which condition is characterized by deep, tense blisters with intact skin?

Pemphigoid Signup and view all the answers

In autoimmune blistering conditions, where does the loss of adhesion occur?

Within the epidermis Signup and view all the answers

Which type of blisters in pemphigus are characterized as fragile and flaccid?

Superficial blisters Signup and view all the answers

What is the characteristic appearance of epidermal cells in conditions leading to spongiosis and vesicle formation?

More intact blisters, less erosions Signup and view all the answers

In autoimmune blistering conditions, what leads to the formation of vesicles between epidermal cells?

Edema Signup and view all the answers

Which autoimmune blistering skin disease is associated with neurologic diseases such as cerebrovascular disease and Multiple Sclerosis?

Bullous Pemphigoid Signup and view all the answers

Which protein complex links the cytoskeleton of the basal keratinocyte to the dermis?

Hemidesmosome Signup and view all the answers

What is the most common autoimmune blistering skin disease?

Bullous Pemphigoid Signup and view all the answers

Which type of deposits are seen at the dermo-epidermal junction in diseases of hemidesmosomes?

IgG Signup and view all the answers

What is the potential trigger for Bullous Pemphigoid among the following?

Antibiotics Signup and view all the answers

'Tense blisters and erosions on a background of dermatitis or normal skin' typically describe the presentation of which condition?

Bullous Pemphigoid Signup and view all the answers

What is a potential consequence of scratching in autoimmune blistering conditions?

Traumatic removal of blister roofs Signup and view all the answers

Which of the following skin conditions is characterized by superficial blisters in the epidermis with a fragile roof that sloughs off easily?

Pemphigus Signup and view all the answers

Which type of deposits are seen at the dermo-epidermal junction in diseases affecting hemidesmosomes?

Subepidermal deposits Signup and view all the answers

What is a common distribution pattern for herpes infections on the body?

Localized to lips, genitals, or dermatomes Signup and view all the answers

In terms of durability, which condition presents with blisters that usually remain intact and have a stronger roof?

Bullous pemphigoid Signup and view all the answers

What symptom can be an indicator of eczema preceding the development of bullous pemphigoid?

Pruritic lesions Signup and view all the answers

Which type of blisters has a thicker roof and is more substantial, as described in the text?

Intra-epidermal blisters Signup and view all the answers

In autoimmune blistering diseases, what can be inherited according to the text?

Susceptibility to develop autoimmune disorders Signup and view all the answers

Which condition is characterized by impaired adhesion of epidermal cells to each other or to the epidermal basement membrane mediated by the immune system?

Autoimmune blistering diseases Signup and view all the answers

Which Desmoglein is more prevalent in the lower epidermis of mucous membranes?

Desmoglein 3 Signup and view all the answers

What is a possible trigger for the production of skin-damaging autoantibodies in some patients according to the text?

Hormones Signup and view all the answers

Which type of blisters have very thin roofs with little structural integrity that easily collapse?

Sub-corneal blisters Signup and view all the answers

Which autoimmune blistering condition results from autoantibodies targeting desmoglein 1?

Pemphigus Vulgaris Signup and view all the answers

In which type of pemphigoid does subcorneal split lead to rapidly and easily rupturing bullae?

Localized/Cicatricial/Mucous membrane pemphigoid Signup and view all the answers

Which autoimmune blistering condition is associated with Neurologic diseases like cerebrovascular disease and Multiple Sclerosis?

Bullous Pemphigoid Signup and view all the answers

Which autoimmune blistering condition is characterized by deep, tense bullae with less erosions?

Para-neoplastic pemphigus Signup and view all the answers

Which protein complex is targeted by autoantibodies in Bullous Pemphigoid?

BP180 Signup and view all the answers

Which type of blistering disease typically presents with more mucosal involvement and less skin involvement?

Pemphigoid Gestationis Signup and view all the answers

What is the main cause of blister formation in autoimmune blistering conditions according to the text?

Edema between epidermal cells Signup and view all the answers

In autoimmune blistering conditions, where does the loss of adhesion occur?

Within the epidermis or at the basement membrane Signup and view all the answers

What is a potential consequence of scalp involvement in Mucous Membrane Pemphigoid?

Increased risk of ocular complications Signup and view all the answers

Where do cutaneous lesions predominantly occur in Pemphigoid Gestationis?

Perioral area and trunk Signup and view all the answers

Which of the following drugs is mentioned in the text as a possible trigger for autoimmune disorders?

Immunosuppressants Signup and view all the answers

'Tense blisters and erosions on a background of dermatitis or normal skin' typically describe the presentation of which condition?

Dermatitis Herpetiformis Signup and view all the answers

Which autoimmune blistering disease is characterized by circulating IgG and basement membrane zone–bound IgG antibodies?

Bullous Pemphigoid Signup and view all the answers

Which protein complex is involved in linking the cytoskeleton of the basal keratinocyte to the dermis?

Hemidesmosome Signup and view all the answers

What is the potential trigger for Bullous Pemphigoid among the following?

UV radiation Signup and view all the answers

Which autoimmune blistering skin disease is associated with neurologic diseases like cerebrovascular disease?

Bullous Pemphigoid Signup and view all the answers

What type of blisters does Bullous Pemphigoid typically present with?

Tense blisters and erosions on a background of dermatitis or normal skin Signup and view all the answers

Where are linear deposits of IgG, C3, or IgA seen in autoimmune sub-epidermal blistering diseases?

At the dermo-epidermal junction Signup and view all the answers

Blistering Disorders

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Questions and Answers

Which condition is characterized by superficial blisters in the epidermis with a fragile roof that sloughs off easily?

What is a common distribution pattern for immunobullous diseases?

What can result in the traumatic removal of blister roofs, potentially confusing the clinical picture?

Which condition may precede bullous pemphigoid?

A tingling sensation may herald the onset of which condition?

Which type of blisters usually have a stronger roof and remain intact?

Which type of blisters have great structural integrity and can remain intact even when firmly compressed?

In which type of blisters does Desmoglein 1 have higher concentration in the skin?

Which Desmoglein is more prominent in the lower epidermis of mucous membranes?

Which of the following is a possible trigger for the production of skin-damaging autoantibodies in some patients?

What is the main cause of autoimmune blistering diseases according to the text?

Which of the following drugs is mentioned in the text as a possible trigger for autoimmune disorders?

What is a common symptom of Pemphigoid Gestationis?

In Pemphigoid Gestationis, where do the cutaneous lesions predominantly occur?

What is a potential consequence of scalp involvement in Mucous Membrane Pemphigoid?

Why should caution be taken if mothers with Pemphigoid Gestationis are breastfeeding?

Which condition presents with more mucosal involvement and less skin involvement?

What is a potential ocular complication of Mucous Membrane Pemphigoid?

What is the main cause of blister formation in autoimmune blistering conditions?

Which condition is characterized by deep, tense blisters with intact skin?

In autoimmune blistering conditions, where does the loss of adhesion occur?

Which type of blisters in pemphigus are characterized as fragile and flaccid?

What is the characteristic appearance of epidermal cells in conditions leading to spongiosis and vesicle formation?

In autoimmune blistering conditions, what leads to the formation of vesicles between epidermal cells?

Which autoimmune blistering skin disease is associated with neurologic diseases such as cerebrovascular disease and Multiple Sclerosis?

Which protein complex links the cytoskeleton of the basal keratinocyte to the dermis?

What is the most common autoimmune blistering skin disease?

Which type of deposits are seen at the dermo-epidermal junction in diseases of hemidesmosomes?

What is the potential trigger for Bullous Pemphigoid among the following?

'Tense blisters and erosions on a background of dermatitis or normal skin' typically describe the presentation of which condition?

What is a potential consequence of scratching in autoimmune blistering conditions?

Which of the following skin conditions is characterized by superficial blisters in the epidermis with a fragile roof that sloughs off easily?

Which type of deposits are seen at the dermo-epidermal junction in diseases affecting hemidesmosomes?

What is a common distribution pattern for herpes infections on the body?

In terms of durability, which condition presents with blisters that usually remain intact and have a stronger roof?

What symptom can be an indicator of eczema preceding the development of bullous pemphigoid?

Which type of blisters has a thicker roof and is more substantial, as described in the text?

In autoimmune blistering diseases, what can be inherited according to the text?

Which condition is characterized by impaired adhesion of epidermal cells to each other or to the epidermal basement membrane mediated by the immune system?

Which Desmoglein is more prevalent in the lower epidermis of mucous membranes?

What is a possible trigger for the production of skin-damaging autoantibodies in some patients according to the text?

Which type of blisters have very thin roofs with little structural integrity that easily collapse?

Which autoimmune blistering condition results from autoantibodies targeting desmoglein 1?

In which type of pemphigoid does subcorneal split lead to rapidly and easily rupturing bullae?

Which autoimmune blistering condition is associated with Neurologic diseases like cerebrovascular disease and Multiple Sclerosis?

Which autoimmune blistering condition is characterized by deep, tense bullae with less erosions?

Which protein complex is targeted by autoantibodies in Bullous Pemphigoid?

Which type of blistering disease typically presents with more mucosal involvement and less skin involvement?

What is the main cause of blister formation in autoimmune blistering conditions according to the text?

In autoimmune blistering conditions, where does the loss of adhesion occur?

What is a potential consequence of scalp involvement in Mucous Membrane Pemphigoid?

Where do cutaneous lesions predominantly occur in Pemphigoid Gestationis?

Which of the following drugs is mentioned in the text as a possible trigger for autoimmune disorders?

'Tense blisters and erosions on a background of dermatitis or normal skin' typically describe the presentation of which condition?

Which autoimmune blistering disease is characterized by circulating IgG and basement membrane zone–bound IgG antibodies?

Which protein complex is involved in linking the cytoskeleton of the basal keratinocyte to the dermis?

What is the potential trigger for Bullous Pemphigoid among the following?

Which autoimmune blistering skin disease is associated with neurologic diseases like cerebrovascular disease?

What type of blisters does Bullous Pemphigoid typically present with?

Where are linear deposits of IgG, C3, or IgA seen in autoimmune sub-epidermal blistering diseases?

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