Blistering Disorders
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Questions and Answers

Which condition is characterized by superficial blisters in the epidermis with a fragile roof that sloughs off easily?

  • Herpes simplex virus
  • Toxic epidermal necrolysis
  • Stevens-Johnson syndrome
  • Pemphigus vulgaris (correct)
  • What is a common distribution pattern for immunobullous diseases?

  • Involve sun-exposed skin
  • Localized to lips or dermatomes
  • Remain intact and are subepidermal
  • Widespread eruptions with mucous membrane involvement (correct)
  • What can result in the traumatic removal of blister roofs, potentially confusing the clinical picture?

  • Linear IgA
  • Epidermolysis bullosa
  • Porphyria cutanea tarda
  • Scratching (correct)
  • Which condition may precede bullous pemphigoid?

    <p>Eczema</p> Signup and view all the answers

    A tingling sensation may herald the onset of which condition?

    <p>Herpes simplex</p> Signup and view all the answers

    Which type of blisters usually have a stronger roof and remain intact?

    <p>Subepidermal blisters</p> Signup and view all the answers

    Which type of blisters have great structural integrity and can remain intact even when firmly compressed?

    <p>Sub-epidermal blisters</p> Signup and view all the answers

    In which type of blisters does Desmoglein 1 have higher concentration in the skin?

    <p>Sub-corneal blisters</p> Signup and view all the answers

    Which Desmoglein is more prominent in the lower epidermis of mucous membranes?

    <p>Desmoglein 3</p> Signup and view all the answers

    Which of the following is a possible trigger for the production of skin-damaging autoantibodies in some patients?

    <p>Viral infections</p> Signup and view all the answers

    What is the main cause of autoimmune blistering diseases according to the text?

    <p>Impaired adhesion of epidermal cells mediated by our immune system</p> Signup and view all the answers

    Which of the following drugs is mentioned in the text as a possible trigger for autoimmune disorders?

    <p>Rifampicin</p> Signup and view all the answers

    What is a common symptom of Pemphigoid Gestationis?

    <p>Painless papules and plaques</p> Signup and view all the answers

    In Pemphigoid Gestationis, where do the cutaneous lesions predominantly occur?

    <p>Around the periumbilical area</p> Signup and view all the answers

    What is a potential consequence of scalp involvement in Mucous Membrane Pemphigoid?

    <p>Scarring alopecia</p> Signup and view all the answers

    Why should caution be taken if mothers with Pemphigoid Gestationis are breastfeeding?

    <p>Due to high doses of systemic corticosteroids in treatment</p> Signup and view all the answers

    Which condition presents with more mucosal involvement and less skin involvement?

    <p>Cicatricial Pemphigoid</p> Signup and view all the answers

    What is a potential ocular complication of Mucous Membrane Pemphigoid?

    <p>Dry eyes</p> Signup and view all the answers

    What is the main cause of blister formation in autoimmune blistering conditions?

    <p>Edema between epidermal cells</p> Signup and view all the answers

    Which condition is characterized by deep, tense blisters with intact skin?

    <p>Pemphigoid</p> Signup and view all the answers

    In autoimmune blistering conditions, where does the loss of adhesion occur?

    <p>Within the epidermis</p> Signup and view all the answers

    Which type of blisters in pemphigus are characterized as fragile and flaccid?

    <p>Superficial blisters</p> Signup and view all the answers

    What is the characteristic appearance of epidermal cells in conditions leading to spongiosis and vesicle formation?

    <p>More intact blisters, less erosions</p> Signup and view all the answers

    In autoimmune blistering conditions, what leads to the formation of vesicles between epidermal cells?

    <p>Edema</p> Signup and view all the answers

    Which autoimmune blistering skin disease is associated with neurologic diseases such as cerebrovascular disease and Multiple Sclerosis?

    <p>Bullous Pemphigoid</p> Signup and view all the answers

    Which protein complex links the cytoskeleton of the basal keratinocyte to the dermis?

    <p>Hemidesmosome</p> Signup and view all the answers

    What is the most common autoimmune blistering skin disease?

    <p>Bullous Pemphigoid</p> Signup and view all the answers

    Which type of deposits are seen at the dermo-epidermal junction in diseases of hemidesmosomes?

    <p>IgG</p> Signup and view all the answers

    What is the potential trigger for Bullous Pemphigoid among the following?

    <p>Antibiotics</p> Signup and view all the answers

    'Tense blisters and erosions on a background of dermatitis or normal skin' typically describe the presentation of which condition?

    <p>Bullous Pemphigoid</p> Signup and view all the answers

    What is a potential consequence of scratching in autoimmune blistering conditions?

    <p>Traumatic removal of blister roofs</p> Signup and view all the answers

    Which of the following skin conditions is characterized by superficial blisters in the epidermis with a fragile roof that sloughs off easily?

    <p>Pemphigus</p> Signup and view all the answers

    Which type of deposits are seen at the dermo-epidermal junction in diseases affecting hemidesmosomes?

    <p>Subepidermal deposits</p> Signup and view all the answers

    What is a common distribution pattern for herpes infections on the body?

    <p>Localized to lips, genitals, or dermatomes</p> Signup and view all the answers

    In terms of durability, which condition presents with blisters that usually remain intact and have a stronger roof?

    <p>Bullous pemphigoid</p> Signup and view all the answers

    What symptom can be an indicator of eczema preceding the development of bullous pemphigoid?

    <p>Pruritic lesions</p> Signup and view all the answers

    Which type of blisters has a thicker roof and is more substantial, as described in the text?

    <p>Intra-epidermal blisters</p> Signup and view all the answers

    In autoimmune blistering diseases, what can be inherited according to the text?

    <p>Susceptibility to develop autoimmune disorders</p> Signup and view all the answers

    Which condition is characterized by impaired adhesion of epidermal cells to each other or to the epidermal basement membrane mediated by the immune system?

    <p>Autoimmune blistering diseases</p> Signup and view all the answers

    Which Desmoglein is more prevalent in the lower epidermis of mucous membranes?

    <p>Desmoglein 3</p> Signup and view all the answers

    What is a possible trigger for the production of skin-damaging autoantibodies in some patients according to the text?

    <p>Hormones</p> Signup and view all the answers

    Which type of blisters have very thin roofs with little structural integrity that easily collapse?

    <p>Sub-corneal blisters</p> Signup and view all the answers

    Which autoimmune blistering condition results from autoantibodies targeting desmoglein 1?

    <p>Pemphigus Vulgaris</p> Signup and view all the answers

    In which type of pemphigoid does subcorneal split lead to rapidly and easily rupturing bullae?

    <p>Localized/Cicatricial/Mucous membrane pemphigoid</p> Signup and view all the answers

    Which autoimmune blistering condition is associated with Neurologic diseases like cerebrovascular disease and Multiple Sclerosis?

    <p>Bullous Pemphigoid</p> Signup and view all the answers

    Which autoimmune blistering condition is characterized by deep, tense bullae with less erosions?

    <p>Para-neoplastic pemphigus</p> Signup and view all the answers

    Which protein complex is targeted by autoantibodies in Bullous Pemphigoid?

    <p>BP180</p> Signup and view all the answers

    Which type of blistering disease typically presents with more mucosal involvement and less skin involvement?

    <p>Pemphigoid Gestationis</p> Signup and view all the answers

    What is the main cause of blister formation in autoimmune blistering conditions according to the text?

    <p>Edema between epidermal cells</p> Signup and view all the answers

    In autoimmune blistering conditions, where does the loss of adhesion occur?

    <p>Within the epidermis or at the basement membrane</p> Signup and view all the answers

    What is a potential consequence of scalp involvement in Mucous Membrane Pemphigoid?

    <p>Increased risk of ocular complications</p> Signup and view all the answers

    Where do cutaneous lesions predominantly occur in Pemphigoid Gestationis?

    <p>Perioral area and trunk</p> Signup and view all the answers

    Which of the following drugs is mentioned in the text as a possible trigger for autoimmune disorders?

    <p>Immunosuppressants</p> Signup and view all the answers

    'Tense blisters and erosions on a background of dermatitis or normal skin' typically describe the presentation of which condition?

    <p>Dermatitis Herpetiformis</p> Signup and view all the answers

    Which autoimmune blistering disease is characterized by circulating IgG and basement membrane zone–bound IgG antibodies?

    <p>Bullous Pemphigoid</p> Signup and view all the answers

    Which protein complex is involved in linking the cytoskeleton of the basal keratinocyte to the dermis?

    <p>Hemidesmosome</p> Signup and view all the answers

    What is the potential trigger for Bullous Pemphigoid among the following?

    <p>UV radiation</p> Signup and view all the answers

    Which autoimmune blistering skin disease is associated with neurologic diseases like cerebrovascular disease?

    <p>Bullous Pemphigoid</p> Signup and view all the answers

    What type of blisters does Bullous Pemphigoid typically present with?

    <p>Tense blisters and erosions on a background of dermatitis or normal skin</p> Signup and view all the answers

    Where are linear deposits of IgG, C3, or IgA seen in autoimmune sub-epidermal blistering diseases?

    <p>At the dermo-epidermal junction</p> Signup and view all the answers

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