Blistering Disorders
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Questions and Answers

Which condition is characterized by superficial blisters in the epidermis with a fragile roof that sloughs off easily?

  • Herpes simplex virus
  • Toxic epidermal necrolysis
  • Stevens-Johnson syndrome
  • Pemphigus vulgaris (correct)

What is a common distribution pattern for immunobullous diseases?

  • Involve sun-exposed skin
  • Localized to lips or dermatomes
  • Remain intact and are subepidermal
  • Widespread eruptions with mucous membrane involvement (correct)

What can result in the traumatic removal of blister roofs, potentially confusing the clinical picture?

  • Linear IgA
  • Epidermolysis bullosa
  • Porphyria cutanea tarda
  • Scratching (correct)

Which condition may precede bullous pemphigoid?

<p>Eczema (A)</p> Signup and view all the answers

A tingling sensation may herald the onset of which condition?

<p>Herpes simplex (D)</p> Signup and view all the answers

Which type of blisters usually have a stronger roof and remain intact?

<p>Subepidermal blisters (A)</p> Signup and view all the answers

Which type of blisters have great structural integrity and can remain intact even when firmly compressed?

<p>Sub-epidermal blisters (B)</p> Signup and view all the answers

In which type of blisters does Desmoglein 1 have higher concentration in the skin?

<p>Sub-corneal blisters (D)</p> Signup and view all the answers

Which Desmoglein is more prominent in the lower epidermis of mucous membranes?

<p>Desmoglein 3 (B)</p> Signup and view all the answers

Which of the following is a possible trigger for the production of skin-damaging autoantibodies in some patients?

<p>Viral infections (B)</p> Signup and view all the answers

What is the main cause of autoimmune blistering diseases according to the text?

<p>Impaired adhesion of epidermal cells mediated by our immune system (B)</p> Signup and view all the answers

Which of the following drugs is mentioned in the text as a possible trigger for autoimmune disorders?

<p>Rifampicin (D)</p> Signup and view all the answers

What is a common symptom of Pemphigoid Gestationis?

<p>Painless papules and plaques (A)</p> Signup and view all the answers

In Pemphigoid Gestationis, where do the cutaneous lesions predominantly occur?

<p>Around the periumbilical area (B)</p> Signup and view all the answers

What is a potential consequence of scalp involvement in Mucous Membrane Pemphigoid?

<p>Scarring alopecia (C)</p> Signup and view all the answers

Why should caution be taken if mothers with Pemphigoid Gestationis are breastfeeding?

<p>Due to high doses of systemic corticosteroids in treatment (C)</p> Signup and view all the answers

Which condition presents with more mucosal involvement and less skin involvement?

<p>Cicatricial Pemphigoid (B)</p> Signup and view all the answers

What is a potential ocular complication of Mucous Membrane Pemphigoid?

<p>Dry eyes (D)</p> Signup and view all the answers

What is the main cause of blister formation in autoimmune blistering conditions?

<p>Edema between epidermal cells (C)</p> Signup and view all the answers

Which condition is characterized by deep, tense blisters with intact skin?

<p>Pemphigoid (C)</p> Signup and view all the answers

In autoimmune blistering conditions, where does the loss of adhesion occur?

<p>Within the epidermis (D)</p> Signup and view all the answers

Which type of blisters in pemphigus are characterized as fragile and flaccid?

<p>Superficial blisters (C)</p> Signup and view all the answers

What is the characteristic appearance of epidermal cells in conditions leading to spongiosis and vesicle formation?

<p>More intact blisters, less erosions (C)</p> Signup and view all the answers

In autoimmune blistering conditions, what leads to the formation of vesicles between epidermal cells?

<p>Edema (C)</p> Signup and view all the answers

Which autoimmune blistering skin disease is associated with neurologic diseases such as cerebrovascular disease and Multiple Sclerosis?

<p>Bullous Pemphigoid (A)</p> Signup and view all the answers

Which protein complex links the cytoskeleton of the basal keratinocyte to the dermis?

<p>Hemidesmosome (C)</p> Signup and view all the answers

What is the most common autoimmune blistering skin disease?

<p>Bullous Pemphigoid (A)</p> Signup and view all the answers

Which type of deposits are seen at the dermo-epidermal junction in diseases of hemidesmosomes?

<p>IgG (D)</p> Signup and view all the answers

What is the potential trigger for Bullous Pemphigoid among the following?

<p>Antibiotics (D)</p> Signup and view all the answers

'Tense blisters and erosions on a background of dermatitis or normal skin' typically describe the presentation of which condition?

<p>Bullous Pemphigoid (A)</p> Signup and view all the answers

What is a potential consequence of scratching in autoimmune blistering conditions?

<p>Traumatic removal of blister roofs (D)</p> Signup and view all the answers

Which of the following skin conditions is characterized by superficial blisters in the epidermis with a fragile roof that sloughs off easily?

<p>Pemphigus (A)</p> Signup and view all the answers

Which type of deposits are seen at the dermo-epidermal junction in diseases affecting hemidesmosomes?

<p>Subepidermal deposits (B)</p> Signup and view all the answers

What is a common distribution pattern for herpes infections on the body?

<p>Localized to lips, genitals, or dermatomes (A)</p> Signup and view all the answers

In terms of durability, which condition presents with blisters that usually remain intact and have a stronger roof?

<p>Bullous pemphigoid (B)</p> Signup and view all the answers

What symptom can be an indicator of eczema preceding the development of bullous pemphigoid?

<p>Pruritic lesions (D)</p> Signup and view all the answers

Which type of blisters has a thicker roof and is more substantial, as described in the text?

<p>Intra-epidermal blisters (C)</p> Signup and view all the answers

In autoimmune blistering diseases, what can be inherited according to the text?

<p>Susceptibility to develop autoimmune disorders (C)</p> Signup and view all the answers

Which condition is characterized by impaired adhesion of epidermal cells to each other or to the epidermal basement membrane mediated by the immune system?

<p>Autoimmune blistering diseases (B)</p> Signup and view all the answers

Which Desmoglein is more prevalent in the lower epidermis of mucous membranes?

<p>Desmoglein 3 (B)</p> Signup and view all the answers

What is a possible trigger for the production of skin-damaging autoantibodies in some patients according to the text?

<p>Hormones (C)</p> Signup and view all the answers

Which type of blisters have very thin roofs with little structural integrity that easily collapse?

<p>Sub-corneal blisters (B)</p> Signup and view all the answers

Which autoimmune blistering condition results from autoantibodies targeting desmoglein 1?

<p>Pemphigus Vulgaris (A)</p> Signup and view all the answers

In which type of pemphigoid does subcorneal split lead to rapidly and easily rupturing bullae?

<p>Localized/Cicatricial/Mucous membrane pemphigoid (B)</p> Signup and view all the answers

Which autoimmune blistering condition is associated with Neurologic diseases like cerebrovascular disease and Multiple Sclerosis?

<p>Bullous Pemphigoid (D)</p> Signup and view all the answers

Which autoimmune blistering condition is characterized by deep, tense bullae with less erosions?

<p>Para-neoplastic pemphigus (A)</p> Signup and view all the answers

Which protein complex is targeted by autoantibodies in Bullous Pemphigoid?

<p>BP180 (A)</p> Signup and view all the answers

Which type of blistering disease typically presents with more mucosal involvement and less skin involvement?

<p>Pemphigoid Gestationis (B)</p> Signup and view all the answers

What is the main cause of blister formation in autoimmune blistering conditions according to the text?

<p>Edema between epidermal cells (B)</p> Signup and view all the answers

In autoimmune blistering conditions, where does the loss of adhesion occur?

<p>Within the epidermis or at the basement membrane (A)</p> Signup and view all the answers

What is a potential consequence of scalp involvement in Mucous Membrane Pemphigoid?

<p>Increased risk of ocular complications (B)</p> Signup and view all the answers

Where do cutaneous lesions predominantly occur in Pemphigoid Gestationis?

<p>Perioral area and trunk (B)</p> Signup and view all the answers

Which of the following drugs is mentioned in the text as a possible trigger for autoimmune disorders?

<p>Immunosuppressants (A)</p> Signup and view all the answers

'Tense blisters and erosions on a background of dermatitis or normal skin' typically describe the presentation of which condition?

<p>Dermatitis Herpetiformis (C)</p> Signup and view all the answers

Which autoimmune blistering disease is characterized by circulating IgG and basement membrane zone–bound IgG antibodies?

<p>Bullous Pemphigoid (B)</p> Signup and view all the answers

Which protein complex is involved in linking the cytoskeleton of the basal keratinocyte to the dermis?

<p>Hemidesmosome (A)</p> Signup and view all the answers

What is the potential trigger for Bullous Pemphigoid among the following?

<p>UV radiation (C)</p> Signup and view all the answers

Which autoimmune blistering skin disease is associated with neurologic diseases like cerebrovascular disease?

<p>Bullous Pemphigoid (A)</p> Signup and view all the answers

What type of blisters does Bullous Pemphigoid typically present with?

<p>Tense blisters and erosions on a background of dermatitis or normal skin (D)</p> Signup and view all the answers

Where are linear deposits of IgG, C3, or IgA seen in autoimmune sub-epidermal blistering diseases?

<p>At the dermo-epidermal junction (A)</p> Signup and view all the answers

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