Podcast
Questions and Answers
Which of the following lipoglycopeptides has the highest volume of distribution?
Which of the following lipoglycopeptides has the highest volume of distribution?
Which of the following is NOT a Gram-negative anaerobic activity of linezolid?
Which of the following is NOT a Gram-negative anaerobic activity of linezolid?
Which of the following is NOT a potential adverse drug reaction (ADR) of daptomycin?
Which of the following is NOT a potential adverse drug reaction (ADR) of daptomycin?
Which of the following organisms is linezolid NOT active against?
Which of the following organisms is linezolid NOT active against?
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Which drug has a higher bioavailability, Linezolid or Clindamycin?
Which drug has a higher bioavailability, Linezolid or Clindamycin?
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Which drug is primarily metabolized by the liver, Linezolid or Clindamycin?
Which drug is primarily metabolized by the liver, Linezolid or Clindamycin?
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Which drug has a longer half-life, Linezolid or Clindamycin?
Which drug has a longer half-life, Linezolid or Clindamycin?
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Which drug has activity against Toxoplasma gondii and is used in combination with pyrimethamine to treat toxoplasmosis?
Which drug has activity against Toxoplasma gondii and is used in combination with pyrimethamine to treat toxoplasmosis?
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Which type of bacteria is Lefamulin NOT active against?
Which type of bacteria is Lefamulin NOT active against?
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Which type of bacteria does Lefamulin have good activity against?
Which type of bacteria does Lefamulin have good activity against?
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Which drug is contraindicated with Lefamulin due to increased concentrations?
Which drug is contraindicated with Lefamulin due to increased concentrations?
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Which adverse effect is NOT associated with Lefamulin?
Which adverse effect is NOT associated with Lefamulin?
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Which type of immunity is characterized by physical barriers, phagocytes, and strategically pre-deployed proteins?
Which type of immunity is characterized by physical barriers, phagocytes, and strategically pre-deployed proteins?
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Which type of immunity evolves and adapts against invading pathogens and is divided into humoral and cellular responses?
Which type of immunity evolves and adapts against invading pathogens and is divided into humoral and cellular responses?
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Which type of immunity is characterized by soluble factors such as lysozymes, complement, C-reactive protein, and interferons?
Which type of immunity is characterized by soluble factors such as lysozymes, complement, C-reactive protein, and interferons?
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Which type of immunity is primarily responsible for forming barriers against an outside environment, such as the skin and lining of the respiratory, gastrointestinal, and genitourinary tracts?
Which type of immunity is primarily responsible for forming barriers against an outside environment, such as the skin and lining of the respiratory, gastrointestinal, and genitourinary tracts?
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Which one of the following is true about Neutrophils?
Which one of the following is true about Neutrophils?
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What is the main role of Vancomycin in the treatment of Gram-positive infections?
What is the main role of Vancomycin in the treatment of Gram-positive infections?
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What is the recommended dosing target for Vancomycin?
What is the recommended dosing target for Vancomycin?
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What is the most common side effect of Vancomycin?
What is the most common side effect of Vancomycin?
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Study Notes
Lipoglycopeptides
- Daptomycin has the highest volume of distribution amongst lipoglycopeptides.
Linezolid
- Gram-negative anaerobic activity is not associated with Linezolid
- Linezolid is not active against vancomycin-resistant Enterococci (VRE).
Daptomycin
- Hepatic dysfunction is not a potential adverse drug reaction (ADR) of daptomycin.
Linezolid vs Clindamycin
- Clindamycin has a higher bioavailability than Linezolid.
- Linezolid is primarily metabolized by the liver.
- Linezolid has a longer half-life than Clindamycin.
### Toxoplasmosis
- Sulfadiazine has activity against Toxoplasma gondii and is used in combination with pyrimethamine to treat toxoplasmosis.
Lefamulin
- Lefamulin is not active against Gram-negative bacteria.
- It has good activity against community-acquired pneumonia (CAP).
- Macrolide antibiotics are contraindicated with Lefamulin due to increased concentrations.
- Hyperglycemia is not an associated adverse effect of Lefamulin.
### Immunity
- Innate immunity is characterized by physical barriers, phagocytes, and strategically pre-deployed proteins.
- Adaptive immunity evolves and adapts against invading pathogens and is divided into humoral and cellular responses.
- Humoral immunity is characterized by soluble factors such as lysozymes, complement, C-reactive protein, and interferons.
- Innate immunity is primarily responsible for forming barriers against an outside environment, such as the skin and lining of the respiratory, gastrointestinal, and genitourinary tracts.
Neutrophils
- Neutrophils are the most abundant type of white blood cell (WBC) and are critical for the innate immune response.
Vancomycin
- Vancomycin is primarily used to treat severe infections caused by Gram-positive bacteria that are resistant to other antibiotics.
- The target trough concentration for Vancomycin is typically 15-20 mg/L.
- Red man syndrome is the most common side effect of Vancomycin.
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Description
Test your knowledge on the mechanism of action and activity of Daptomycin, a lipopeptide antibiotic. Learn about its effectiveness against Gram positive bacteria, including Vancomycin resistant Enterococci (VRE), Methicillin-resistant Staphylococcus aureus (MRSA), and Methicillin-sensitive Staphylococcus aureus (MSSA).
