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Questions and Answers

What is the diameter of actin filaments?

  • 10-12 nm
  • 3-5 nm
  • 15-18 nm
  • 6-8 nm (correct)
  • Which protein is responsible for cross-linking actin filaments into parallel bundles?

  • Keratin
  • Myosin
  • Fimbrin (correct)
  • Tropomyosin
  • What is the main function of actin filaments in peripheral cell processes?

  • Provide structural support for the cytoplasm (correct)
  • Facilitate intracellular transport
  • Form microvilli and stereocilia
  • Initiate cell contraction
  • Which type of actin is polymerized to form actin filaments?

    <p>F-actin</p> Signup and view all the answers

    What is the role of actin filaments in conjunction with myosin?

    <p>Bring about cell contraction and associated motility</p> Signup and view all the answers

    Which protein is abundant in all cells, particularly muscle cells?

    <p>Actin</p> Signup and view all the answers

    Which form of cell death is characterised by the blebbing of the plasma membrane and the formation of apoptotic bodies?

    <p>Apoptosis</p> Signup and view all the answers

    Which form of cell death involves plasma membrane rupture, leakage of cytoplasmic contents, and cell vacuolisation, resembling apoptosis but inducing an inflammatory reaction similar to necrosis?

    <p>Pyroptosis</p> Signup and view all the answers

    Which form of cell death is important in embryologic development, homeostasis, and involution of organs or tissues deprived of hormonal stimulation or growth factors?

    <p>Apoptosis</p> Signup and view all the answers

    Which form of cell death is a regulated form of cell death directed by signaling pathways in response to certain types of injury?

    <p>Apoptosis</p> Signup and view all the answers

    Which form of cell death involves receptor-induced cell death that occurs as a defense mechanism against neurodegenerative processes and viral infections when the cell cannot enter apoptosis?

    <p>Necroptosis</p> Signup and view all the answers

    Which form of cell death involves dilation of the rough endoplasmic reticulum, disruption of lysosomes, and destruction of the plasma membrane with the release of cellular contents to the exterior?

    <p>Necrosis</p> Signup and view all the answers

    Which form of cell death is induced in cells of the innate immune system, such as monocytes, macrophages, and dendritic cells, in the presence of pathogen-associated molecular patterns (PAMPs) expressed on microbial pathogens or by cell-derived DAMPs?

    <p>Pyroptosis</p> Signup and view all the answers

    What is the structure of a centrosome?

    <p>Two centrioles connected by an interconnecting fiber surrounded by pericentriolar material</p> Signup and view all the answers

    What is the structure of cilia in animal cells?

    <p>Axoneme, basal plate, basal body, and striated rootlets</p> Signup and view all the answers

    What is the function of centrosomes during mitosis?

    <p>Act as microtubule-organizing centers and direct microtubule formation</p> Signup and view all the answers

    What is the structure of the axoneme in cilia?

    <p>Nine peripheral microtubule doublets and two single central microtubules with dynein arms and central pair sheath</p> Signup and view all the answers

    What is the basal body structurally similar to?

    <p>The centriole</p> Signup and view all the answers

    What is required for ciliary movement?

    <p>ATP, tubulin, dynein, and nexin, involving an effective stroke and a slow recovery stroke</p> Signup and view all the answers

    What is the function of actin filaments in cell division during mitosis?

    <p>Contributing to the contractile ring</p> Signup and view all the answers

    What is the composition of microtubules?

    <p>Elongated protein cylinders composed of tubulin dimers</p> Signup and view all the answers

    What is a characteristic of intermediate filaments?

    <p>Provide structural support for the cell and are least soluble components of the cytosol</p> Signup and view all the answers

    What is the role of microtubules in intracellular vesicular transport?

    <p>Contributing to the spatial organization of organelles and intracellular vesicular transport</p> Signup and view all the answers

    What is the structure of centrioles?

    <p>Occur in pairs, are made up of nine microtubule triplets, and originate from another centriole</p> Signup and view all the answers

    What is the function of actin filaments in cellular movement?

    <p>Mediating endo- and exocytosis processes and cellular movement</p> Signup and view all the answers

    Actin filaments are thicker, more rigid, and longer than microtubules.

    <p>False</p> Signup and view all the answers

    Actin filaments consist of two forms of actin: free G-actin and polymerised F-actin.

    <p>True</p> Signup and view all the answers

    The cytoskeleton of animal cells does not play a role in maintaining cellular morphology.

    <p>False</p> Signup and view all the answers

    The actin-bundling protein fimbrin is responsible for cross-linking actin filaments into parallel bundles, giving rise to microvilli and stereocilia.

    <p>True</p> Signup and view all the answers

    Actin filaments do not provide structural support for the cytoplasm.

    <p>False</p> Signup and view all the answers

    The cytoskeleton of animal cells does not contribute to intracellular transport of organelles and vesicles within the cytoplasm.

    <p>False</p> Signup and view all the answers

    Actin filaments contribute to the contractile ring during cell division in mitosis

    <p>True</p> Signup and view all the answers

    Intermediate filaments do not disassemble and reform, constituting permanent structural elements of the cell

    <p>False</p> Signup and view all the answers

    Thirteen protofilaments combine to form the wall of the microtubule

    <p>False</p> Signup and view all the answers

    Microtubules are impermanent and can be rapidly assembled and dismantled

    <p>False</p> Signup and view all the answers

    Centrioles occur in pairs, are made up of nine microtubule triplets, and originate from another centriole

    <p>True</p> Signup and view all the answers

    Actin, in combination with filamin and α-actinin, forms a flexible mesh in the cytoplasm

    <p>True</p> Signup and view all the answers

    Pyroptosis is generally a primary response to infectious organisms.

    <p>True</p> Signup and view all the answers

    Apoptosis involves dilation of the rough endoplasmic reticulum and disruption of lysosomes.

    <p>False</p> Signup and view all the answers

    Necrosis is a form of programmed cell death.

    <p>False</p> Signup and view all the answers

    Necroptosis is a receptor-induced cell death that occurs as a defense mechanism against neurodegenerative processes and viral infections when the cell cannot enter apoptosis.

    <p>True</p> Signup and view all the answers

    Apoptotic bodies contain nuclear fragments, organelles, and condensed cytosol enveloped by the plasma membrane.

    <p>True</p> Signup and view all the answers

    Necrosis characteristically involves the blebbing of the plasma membrane.

    <p>False</p> Signup and view all the answers

    Pyroptosis involves the release of cell contents into the extracellular cell matrix.

    <p>True</p> Signup and view all the answers

    Centrioles duplicate during the cell cycle, with the mother centriole duplicating faster and acquiring additional appendages, becoming a new mother centriole.

    <p>True</p> Signup and view all the answers

    The basal body is structurally similar to the centriole and supports cilia.

    <p>True</p> Signup and view all the answers

    Ciliary movement requires ATP, tubulin, dynein, and nexin, involving an effective stroke and a slow recovery stroke.

    <p>True</p> Signup and view all the answers

    Cell differentiation involves transformations enabling cells to carry out specific functions and occurs in interphase, with an antagonism between division and differentiation.

    <p>True</p> Signup and view all the answers

    Cell death can be reversible under certain circumstances.

    <p>False</p> Signup and view all the answers

    The axoneme of cilia is composed of nine peripheral microtubule doublets and two single central microtubules, with dynein arms and central pair sheath.

    <p>True</p> Signup and view all the answers

    Actin filaments (diameter 6–8 nm) are thinner, more flexible and shorter than ______

    <p>microtubules</p> Signup and view all the answers

    Actin filaments consist of two forms of actin: free G-actin (globular actin) and polymerised ______ (filamentous actin)

    <p>F-actin</p> Signup and view all the answers

    Actin filaments form a dense network that interconnects individual ______

    <p>organelles</p> Signup and view all the answers

    They act together with ______ (tropomyosin) filaments to bring about cell contraction and associated motility

    <p>myosin</p> Signup and view all the answers

    Cross-linking of actin filaments into parallel bundles by the actin-bundling protein ______ gives rise to the structural core of specialised cell surface projections known as microvilli and stereocilia

    <p>fimbrin</p> Signup and view all the answers

    Actin is an abundant protein in all cells, particularly ______ cells

    <p>muscle</p> Signup and view all the answers

    Centrosomes consist of two ______ (mother and daughter) connected by an interconnecting fiber, surrounded by pericentriolar material (PCM).

    <p>centrioles</p> Signup and view all the answers

    During the cell cycle, both centrioles duplicate, with the mother centriole duplicating faster and acquiring additional appendages, becoming a new mother ______.

    <p>centriole</p> Signup and view all the answers

    Cilia are motile projections in animal cells, consisting of the axoneme, basal plate, basal body, and ______ rootlets.

    <p>striated</p> Signup and view all the answers

    The axoneme is a structure with nine peripheral microtubule doublets and two single central microtubules, with dynein arms and central pair ______.

    <p>sheath</p> Signup and view all the answers

    Ciliary movement requires ATP, tubulin, dynein, and ______, involving an effective stroke and a slow recovery stroke.

    <p>nexin</p> Signup and view all the answers

    Cell differentiation involves transformations enabling cells to carry out specific functions and occurs in ______, with an antagonism between division and differentiation.

    <p>interphase</p> Signup and view all the answers

    Actin filaments provide structural support for the cell and are least soluble components of the cytosol

    <p>Intermediate filaments</p> Signup and view all the answers

    Microtubules are involved in chromosome attachment and movement during mitosis and meiosis

    <p>Centrioles</p> Signup and view all the answers

    Intermediate filaments provide structural support for the cell and are least soluble components of the cytosol

    <p>Actin filaments</p> Signup and view all the answers

    Centrioles occur in pairs, are made up of nine microtubule triplets, and originate from another centriole

    <p>Microtubules</p> Signup and view all the answers

    Thirteen protofilaments combine to form the wall of the microtubule

    <p>Microtubules</p> Signup and view all the answers

    Centrioles are involved in cell division and the formation of cilia and flagella

    <p>Microtubules</p> Signup and view all the answers

    Apoptosis is a form of programmed cell death that is important in embryologic development, homeostasis, and involution of organs or tissues deprived of hormonal stimulation or growth factors. It is also a regulated form of cell death that is directed by signaling pathways in response to certain types of injury. In apoptosis, nuclear chromatin is condensed and fragmented, but the nuclear envelope is maintained. The cytoplasmic volume decreases due to water loss and protein condensation, but most of the organoids remain intact. The second stage of the process is characterised by the blebbing of the plasma membrane, which eventually fragments and the appearance of so-called ______ bodies that contain nuclear fragments, organelles, and condensed cytosol enveloped by these membrane fragments. The plasma membrane that surrounds ______ bodies prevents the inflammation occurring with necrotic cell death but does express factors to attract phagocytes and stimulate heterophagy. Pyroptosis (Pro-inflammatory cell death) resembles apoptosis in that it is receptor-mediated, but the differences are that it involves plasma membrane rupture, leakage of cytoplasmic contents, cell vacuolisation and inflammatory reaction similar to necrosis. In fact, pyroptosis is generally a primary response to infectious organisms. Pyroptosis is induced in cells of the innate immune system, such as monocytes, marcrophages, and dendritic cells in the presence of pathogen-associated molecular patterns (PAMPs) expressed on microbial pathogens or by cell-derived DAMPs. Necroptosis (Pro-inflammatory Programmed Necrosis) is a receptor-induced cell death that occurs as a defence mechanism against neurodegenerative processes and viral infections when the cell cannot enter apoptosis. Thus, necroptosis is a cell defense pathway that is activated under conditions in which apoptosis is inhibited. The similarities of necroptosis with apoptosis are receptor-mediated and that it occurs in individual cells, but morphologically it is more similar to necrosis (cell swelling, cytoplasmic rupture, outgrowth of cytoplasmic contents, induces inflammatory reaction)

    <p>apoptotic</p> Signup and view all the answers

    Pyroptosis (Pro-inflammatory cell death) resembles apoptosis in that it is receptor-mediated, but the differences are that it involves plasma membrane rupture, leakage of cytoplasmic contents, cell vacuolisation and inflammatory reaction similar to necrosis. In fact, pyroptosis is generally a primary response to infectious organisms. Pyroptosis is induced in cells of the innate immune system, such as monocytes, marcrophages, and dendritic cells in the presence of pathogen-associated molecular patterns (PAMPs) expressed on microbial pathogens or by cell-derived DAMPs. Necroptosis (Pro-inflammatory Programmed Necrosis) is a receptor-induced cell death that occurs as a defence mechanism against neurodegenerative processes and viral infections when the cell cannot enter apoptosis. Thus, necroptosis is a cell defense pathway that is activated under conditions in which apoptosis is inhibited. The similarities of necroptosis with apoptosis are receptor-mediated and that it occurs in individual cells, but morphologically it is more similar to necrosis (cell swelling, cytoplasmic rupture, outgrowth of cytoplasmic contents, induces inflammatory reaction)

    <p>necroptotic</p> Signup and view all the answers

    Pyroptosis is induced in cells of the innate immune system, such as monocytes, marcrophages, and dendritic cells in the presence of pathogen-associated molecular patterns (PAMPs) expressed on microbial pathogens or by cell-derived DAMPs. Necroptosis (Pro-inflammatory Programmed Necrosis) is a ______ cell death that occurs as a defence mechanism against neurodegenerative processes and viral infections when the cell cannot enter apoptosis. Thus, necroptosis is a cell defense pathway that is activated under conditions in which apoptosis is inhibited. The similarities of necroptosis with apoptosis are receptor-mediated and that it occurs in individual cells, but morphologically it is more similar to necrosis (cell swelling, cytoplasmic rupture, outgrowth of cytoplasmic contents, induces inflammatory reaction)

    <p>receptor-induced</p> Signup and view all the answers

    Necroptosis (Pro-inflammatory Programmed Necrosis) is a receptor-induced cell death that occurs as a ______ mechanism against neurodegenerative processes and viral infections when the cell cannot enter apoptosis. Thus, necroptosis is a cell defense pathway that is activated under conditions in which apoptosis is inhibited. The similarities of necroptosis with apoptosis are receptor-mediated and that it occurs in individual cells, but morphologically it is more similar to necrosis (cell swelling, cytoplasmic rupture, outgrowth of cytoplasmic contents, induces inflammatory reaction)

    <p>defence</p> Signup and view all the answers

    Pyroptosis is induced in cells of the innate immune system, such as monocytes, marcrophages, and dendritic cells in the presence of pathogen-associated molecular patterns (PAMPs) expressed on microbial pathogens or by cell-derived DAMPs. Necroptosis (Pro-______ Programmed Necrosis) is a receptor-induced cell death that occurs as a defence mechanism against neurodegenerative processes and viral infections when the cell cannot enter apoptosis. Thus, necroptosis is a cell defense pathway that is activated under conditions in which apoptosis is inhibited. The similarities of necroptosis with apoptosis are receptor-mediated and that it occurs in individual cells, but morphologically it is more similar to necrosis (cell swelling, cytoplasmic rupture, outgrowth of cytoplasmic contents, induces ______ reaction)

    <p>inflammatory</p> Signup and view all the answers

    Necroptosis (Pro-inflammatory Programmed Necrosis) is a receptor-induced cell death that occurs as a defence mechanism against neurodegenerative processes and viral infections when the cell cannot enter apoptosis. Thus, necroptosis is a cell defense pathway that is activated under conditions in which apoptosis is inhibited. The similarities of necroptosis with apoptosis are receptor-mediated and that it occurs in individual cells, but morphologically it is more similar to necrosis (cell swelling, cytoplasmic rupture, outgrowth of cytoplasmic contents, induces inflammatory reaction)

    <p>inhibits</p> Signup and view all the answers

    Pyroptosis is induced in cells of the innate immune system, such as monocytes, marcrophages, and dendritic cells in the presence of pathogen-associated molecular patterns (PAMPs) expressed on microbial pathogens or by cell-derived DAMPs. Necroptosis (Pro-inflammatory Programmed Necrosis) is a receptor-induced cell death that occurs as a defence mechanism against neurodegenerative processes and viral infections when the cell cannot enter apoptosis. Thus, necroptosis is a cell defense ______ that is activated under conditions in which apoptosis is inhibited. The similarities of necroptosis with apoptosis are receptor-mediated and that it occurs in individual cells, but morphologically it is more similar to necrosis (cell swelling, cytoplasmic rupture, outgrowth of cytoplasmic contents, induces inflammatory reaction)

    <p>pathway</p> Signup and view all the answers

    What is the structure and function of actin filaments in the cytoskeleton?

    <p>Actin filaments contribute to the contractile ring during cell division in mitosis, mediate endo- and exocytosis processes, form a flexible mesh in the cytoplasm in combination with filamin and α-actinin, and contribute to cellular movement.</p> Signup and view all the answers

    What are the characteristics and functions of intermediate filaments?

    <p>Intermediate filaments provide structural support for the cell, are the least soluble components of the cytosol, and constitute permanent structural elements of the cell as they do not disassemble and reform.</p> Signup and view all the answers

    Describe the composition and roles of microtubules in the cell.

    <p>Microtubules are elongated protein cylinders composed of tubulin dimers, contribute to the spatial organization of organelles and intracellular vesicular transport, are involved in chromosome attachment and movement during mitosis and meiosis, and can be rapidly assembled and dismantled.</p> Signup and view all the answers

    What are the characteristics and functions of centrioles in the cell?

    <p>Centrioles occur in pairs, are made up of nine microtubule triplets, are involved in cell division, and play a role in the formation of cilia and flagella.</p> Signup and view all the answers

    Explain the structure of the microtubule and its wall formation.

    <p>Thirteen protofilaments combine to form the wall of the microtubule.</p> Signup and view all the answers

    What is the role of centrioles in the cell cycle and their origin?

    <p>Centrioles duplicate during the cell cycle, with the mother centriole duplicating faster and acquiring additional appendages, becoming a new mother centriole.</p> Signup and view all the answers

    Explain the functions of actin filaments or microfilaments in the cytoskeleton of animal cells.

    <p>Actin filaments extend into peripheral cell processes to provide structural support for the cytoplasm, act together with myosin filaments to bring about cell contraction and associated motility, and cross-link into parallel bundles to form specialized cell surface projections known as microvilli and stereocilia.</p> Signup and view all the answers

    What are the three components of the cytoskeleton in animal cells?

    <p>The three components of the cytoskeleton in animal cells are actin filaments (microfilaments), intermediate filaments, and microtubules.</p> Signup and view all the answers

    Describe the structure and composition of actin filaments in animal cells.

    <p>Actin filaments consist of two forms of actin: free G-actin (globular actin) and polymerised F-actin (filamentous actin), and they form a dense network that interconnects individual organelles.</p> Signup and view all the answers

    What is the diameter of actin filaments and how does it compare to microtubules?

    <p>The diameter of actin filaments is 6–8 nm, making them thinner, more flexible, and shorter than microtubules.</p> Signup and view all the answers

    Explain the role of actin filaments in cell contraction and associated motility.

    <p>Actin filaments act together with myosin filaments to bring about cell contraction and associated motility.</p> Signup and view all the answers

    What specialized cell surface projections are formed by the cross-linking of actin filaments, and how are they formed?

    <p>The cross-linking of actin filaments into parallel bundles by the actin-bundling protein fimbrin gives rise to the structural core of specialized cell surface projections known as microvilli and stereocilia.</p> Signup and view all the answers

    Explain the structure and function of centrosomes during the cell cycle.

    <p>Centrosomes consist of two centrioles (mother and daughter) connected by an interconnecting fiber, surrounded by pericentriolar material (PCM). During the cell cycle, both centrioles duplicate, with the mother centriole duplicating faster and acquiring additional appendages, becoming a new mother centriole. Centrosomes act as microtubule-organizing centers during mitosis and direct microtubule formation.</p> Signup and view all the answers

    Describe the components and functions of cilia in animal cells.

    <p>Cilia are motile projections in animal cells, consisting of the axoneme, basal plate, basal body, and striated rootlets. The axoneme is a structure with nine peripheral microtubule doublets and two single central microtubules, with dynein arms and central pair sheath. The basal plate marks the transition from the axoneme to the basal body, which is structurally similar to the centriole and supports cilia. Ciliary movement requires ATP, tubulin, dynein, and nexin, involving an effective stroke and a slow recovery stroke.</p> Signup and view all the answers

    What are the different types of cell death and their characteristics?

    <p>Cell death includes irreversible cessation of all vital cell manifestations, with different types such as necrosis, apoptosis, pyroptosis, and necroptosis. Necrosis refers to cell death due to irreversible cell injury, leading to oncosis and eventual rupture of cell membranes. Apoptosis is important in embryologic development, homeostasis, and involution of organs or tissues deprived of hormonal stimulation or growth factors. Pyroptosis and necroptosis are pro-inflammatory cell death processes induced in cells of the innate immune system, with distinct characteristics.</p> Signup and view all the answers

    Explain the process of cell differentiation and the antagonism between division and differentiation.

    <p>Cell differentiation involves transformations enabling cells to carry out specific functions and occurs in interphase, with an antagonism between division and differentiation. Cell classification based on differentiation degree includes stable, expanding, and labile cell populations.</p> Signup and view all the answers

    Discuss the structure and composition of actin filaments and their role in cellular processes.

    <p>Actin filaments consist of free G-actin (globular actin) and polymerized F-actin. They form a flexible mesh in the cytoplasm and provide structural support for the cytoplasm. Actin, in combination with filamin and α-actinin, forms a flexible mesh in the cytoplasm and is involved in cell contraction and associated motility.</p> Signup and view all the answers

    Explain the characteristics and functions of intermediate filaments in animal cells.

    <p>Intermediate filaments provide structural support for the cell and are the least soluble components of the cytosol. They do not disassemble and reform, constituting permanent structural elements of the cell.</p> Signup and view all the answers

    Explain the morphological characteristics of necrosis and compare them with those of apoptosis.

    <p>Necrosis is characterized by condensation and fragmentation of the chromatin, destruction of the nuclear envelope, dilation of the rough endoplasmic reticulum, disruption of lysosomes, formation of amorphous densities in mitochondria, and destruction of the plasma membrane. Apoptosis involves condensed and fragmented nuclear chromatin, maintained nuclear envelope, decreased cytoplasmic volume due to water loss and protein condensation, blebbing of the plasma membrane, and formation of apoptotic bodies containing nuclear fragments and organelles enveloped by membrane fragments.</p> Signup and view all the answers

    Describe the similarities and differences between pyroptosis and apoptosis.

    <p>Pyroptosis and apoptosis are both receptor-mediated forms of cell death. The differences lie in the morphological characteristics, where pyroptosis involves plasma membrane rupture, leakage of cytoplasmic contents, and cell vacuolization, resembling apoptosis but inducing an inflammatory reaction similar to necrosis.</p> Signup and view all the answers

    Discuss the role of necroptosis as a defense mechanism and its morphological similarities to necrosis and apoptosis.

    <p>Necroptosis is activated under conditions where apoptosis is inhibited, serving as a defense pathway against neurodegenerative processes and viral infections. Morphologically, necroptosis shares similarities with necrosis in terms of cell swelling, cytoplasmic rupture, and induction of an inflammatory reaction, while also involving receptor-mediated pathways like apoptosis.</p> Signup and view all the answers

    Explain the induction of pyroptosis and its significance in the innate immune system.

    <p>Pyroptosis is induced in cells of the innate immune system, such as monocytes, macrophages, and dendritic cells, in the presence of pathogen-associated molecular patterns (PAMPs) expressed on microbial pathogens or by cell-derived DAMPs. It serves as a primary response to infectious organisms.</p> Signup and view all the answers

    What are the characteristics of necroptosis and how does it differ from apoptosis?

    <p>Necroptosis is a receptor-induced cell death with morphological similarities to necrosis, including cell swelling, cytoplasmic rupture, and induction of an inflammatory reaction. It differs from apoptosis in its occurrence as a defense mechanism against neurodegenerative processes and viral infections when the cell cannot enter apoptosis.</p> Signup and view all the answers

    Compare and contrast the morphological features of necroptosis, apoptosis, and pyroptosis.

    <p>Necroptosis shares morphological similarities with necrosis, such as cell swelling, cytoplasmic rupture, and induction of an inflammatory reaction, while also involving receptor-mediated pathways like apoptosis. Pyroptosis involves plasma membrane rupture, leakage of cytoplasmic contents, and cell vacuolization, resembling apoptosis but inducing an inflammatory reaction similar to necrosis.</p> Signup and view all the answers

    Discuss the significance of apoptosis in embryologic development, homeostasis, and response to injury.

    <p>Apoptosis plays a crucial role in embryologic development, homeostasis, and response to certain types of injury by serving as a regulated form of cell death directed by signaling pathways. Its characteristics include condensed and fragmented nuclear chromatin, blebbing of the plasma membrane, and the formation of apoptotic bodies.</p> Signup and view all the answers

    Study Notes

    The Cytoskeleton: Actin Filaments, Intermediate Filaments, Microtubules, and Centrioles

    • Actin filaments contribute to the contractile ring during cell division in mitosis
    • Actin filaments mediate endo- and exocytosis processes and cellular movement
    • Actin, in combination with filamin and α-actinin, forms a flexible mesh in the cytoplasm
    • Intermediate filaments provide structural support for the cell and are least soluble components of the cytosol
    • Intermediate filaments do not disassemble and reform, constituting permanent structural elements of the cell
    • Microtubules are elongated protein cylinders composed of tubulin dimers
    • Thirteen protofilaments combine to form the wall of the microtubule
    • Microtubules are impermanent and can be rapidly assembled and dismantled
    • Microtubules contribute to the spatial organization of organelles and intracellular vesicular transport
    • Microtubules are involved in chromosome attachment and movement during mitosis and meiosis
    • Centrioles are involved in cell division and the formation of cilia and flagella
    • Centrioles occur in pairs, are made up of nine microtubule triplets, and originate from another centriole

    Centrioles and Cilia Structure and Functions

    • Centrosomes consist of two centrioles (mother and daughter) connected by an interconnecting fiber, surrounded by pericentriolar material (PCM).
    • During the cell cycle, both centrioles duplicate, with the mother centriole duplicating faster and acquiring additional appendages, becoming a new mother centriole.
    • Centrosomes act as microtubule-organizing centers during mitosis and direct microtubule formation.
    • Cilia are motile projections in animal cells, consisting of the axoneme, basal plate, basal body, and striated rootlets.
    • The axoneme is a structure with nine peripheral microtubule doublets and two single central microtubules, with dynein arms and central pair sheath.
    • The basal plate marks the transition from the axoneme to the basal body, which is structurally similar to the centriole and supports cilia.
    • Ciliary movement requires ATP, tubulin, dynein, and nexin, involving an effective stroke and a slow recovery stroke.
    • Cell differentiation involves transformations enabling cells to carry out specific functions and occurs in interphase, with an antagonism between division and differentiation.
    • Cell classification based on differentiation degree includes stable, expanding, and labile cell populations.
    • Cell death is the irreversible cessation of all vital cell manifestations, with different types such as necrosis, apoptosis, pyroptosis, and necroptosis.
    • The term necrosis refers to cell death due to irreversible cell injury, leading to oncosis and eventual rupture of cell membranes.
    • Detailed study of cell death types is part of the General Anatomical Pathology discipline.

    The Cytoskeleton: Actin Filaments, Intermediate Filaments, Microtubules, and Centrioles

    • Actin filaments contribute to the contractile ring during cell division in mitosis
    • Actin filaments mediate endo- and exocytosis processes and cellular movement
    • Actin, in combination with filamin and α-actinin, forms a flexible mesh in the cytoplasm
    • Intermediate filaments provide structural support for the cell and are least soluble components of the cytosol
    • Intermediate filaments do not disassemble and reform, constituting permanent structural elements of the cell
    • Microtubules are elongated protein cylinders composed of tubulin dimers
    • Thirteen protofilaments combine to form the wall of the microtubule
    • Microtubules are impermanent and can be rapidly assembled and dismantled
    • Microtubules contribute to the spatial organization of organelles and intracellular vesicular transport
    • Microtubules are involved in chromosome attachment and movement during mitosis and meiosis
    • Centrioles are involved in cell division and the formation of cilia and flagella
    • Centrioles occur in pairs, are made up of nine microtubule triplets, and originate from another centriole

    Centrioles and Cilia Structure and Functions

    • Centrosomes consist of two centrioles (mother and daughter) connected by an interconnecting fiber, surrounded by pericentriolar material (PCM).
    • During the cell cycle, both centrioles duplicate, with the mother centriole duplicating faster and acquiring additional appendages, becoming a new mother centriole.
    • Centrosomes act as microtubule-organizing centers during mitosis and direct microtubule formation.
    • Cilia are motile projections in animal cells, consisting of the axoneme, basal plate, basal body, and striated rootlets.
    • The axoneme is a structure with nine peripheral microtubule doublets and two single central microtubules, with dynein arms and central pair sheath.
    • The basal plate marks the transition from the axoneme to the basal body, which is structurally similar to the centriole and supports cilia.
    • Ciliary movement requires ATP, tubulin, dynein, and nexin, involving an effective stroke and a slow recovery stroke.
    • Cell differentiation involves transformations enabling cells to carry out specific functions and occurs in interphase, with an antagonism between division and differentiation.
    • Cell classification based on differentiation degree includes stable, expanding, and labile cell populations.
    • Cell death is the irreversible cessation of all vital cell manifestations, with different types such as necrosis, apoptosis, pyroptosis, and necroptosis.
    • The term necrosis refers to cell death due to irreversible cell injury, leading to oncosis and eventual rupture of cell membranes.
    • Detailed study of cell death types is part of the General Anatomical Pathology discipline.

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    Description

    Test your knowledge of the cytoskeleton with this quiz on actin filaments, intermediate filaments, microtubules, and centrioles. Explore their roles in cell division, structural support, cellular movement, and organelle organization.

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