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Cytokines and Interleukins in Immune Response

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Cytokines and Interleukins in Immune Response

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Questions and Answers

Which cells play a key role in establishing peripheral tolerance to a wide variety of self-antigens, allergens, tumor antigens, transplant antigens, and infectious agents?

T Regulatory Cells (correct)

Th1 cells

B cells

CD8+T cells

What is the major effect of IL-10?

Induces the production of MHC-II on B cells

Stimulates CD8+T cells

Enhances antigen presentation by macrophages and dendritic cells

Inhibits IFN-Y production via the suppression of IL-12 synthesis (correct)

Where are Tregs (T Regulatory Cells) selected?

Lymph nodes

Spleen

Bone marrow

Thymus (correct)

What does IL-10 inhibit?

Antigen presentation by macrophages and dendritic cells Signup and view all the answers

Which cells produce Interleukin-10 (IL-10)?

CD8+T cells Signup and view all the answers

Which cytokine production is suppressed by IL-10?

IFN-Y Signup and view all the answers

What is the role of T Regulatory Cells in transplanted tissue?

Suppress the immune response against the graft Signup and view all the answers

How does IFN-Y affect antigen presentation by antigen-presenting cells?

Stimulates antigen presentation by MHC I and MHC II molecules Signup and view all the answers

What is the role of IL-12 in relation to natural killer (NK) cells?

Increases the cytolytic ability of NK cells Signup and view all the answers

What is the impact of IL-2 secretion by Th1 cells on T-cell growth and differentiation?

Drives the growth and differentiation of T and B cells Signup and view all the answers

How do IL-2 and IFN-Y contribute to the development of Th1 cells?

Induce the development of Th1 cells Signup and view all the answers

What are the actions of Th1 cells in relation to macrophage activation and hypersensitivity?

Induces macrophage activation and delayed type hypersensitivity Signup and view all the answers

Which cells does IL-2 activate to proliferate and generate IgG1 and IgE producing cells?

Th2 cells Signup and view all the answers

What is the primary responsibility of Th2 cells in immunity?

Antibody-mediated immunity Signup and view all the answers

How does IL-4 influence the immune response in relation to Th2 cells?

Regulates Th2 immune activities and drives antibody responses Signup and view all the answers

What effect does IL-4 have on naïve T cells in terms of Th2 cell generation?

Turns on genes that generate Th2 cells and turns off genes that promote Th1 cells Signup and view all the answers

What immune responses are regulated by Th2 cells?

Regulates many aspects of the immune response Signup and view all the answers