17 Questions
Which cells play a key role in establishing peripheral tolerance to a wide variety of self-antigens, allergens, tumor antigens, transplant antigens, and infectious agents?
T Regulatory Cells
What is the major effect of IL-10?
Inhibits IFN-Y production via the suppression of IL-12 synthesis
Where are Tregs (T Regulatory Cells) selected?
Thymus
What does IL-10 inhibit?
Antigen presentation by macrophages and dendritic cells
Which cells produce Interleukin-10 (IL-10)?
CD8+T cells
Which cytokine production is suppressed by IL-10?
IFN-Y
What is the role of T Regulatory Cells in transplanted tissue?
Suppress the immune response against the graft
How does IFN-Y affect antigen presentation by antigen-presenting cells?
Stimulates antigen presentation by MHC I and MHC II molecules
What is the role of IL-12 in relation to natural killer (NK) cells?
Increases the cytolytic ability of NK cells
What is the impact of IL-2 secretion by Th1 cells on T-cell growth and differentiation?
Drives the growth and differentiation of T and B cells
How do IL-2 and IFN-Y contribute to the development of Th1 cells?
Induce the development of Th1 cells
What are the actions of Th1 cells in relation to macrophage activation and hypersensitivity?
Induces macrophage activation and delayed type hypersensitivity
Which cells does IL-2 activate to proliferate and generate IgG1 and IgE producing cells?
Th2 cells
What is the primary responsibility of Th2 cells in immunity?
Antibody-mediated immunity
How does IL-4 influence the immune response in relation to Th2 cells?
Regulates Th2 immune activities and drives antibody responses
What effect does IL-4 have on naïve T cells in terms of Th2 cell generation?
Turns on genes that generate Th2 cells and turns off genes that promote Th1 cells
What immune responses are regulated by Th2 cells?
Regulates many aspects of the immune response
Learn about the role of cytokines in immune activation and how they regulate leukocyte activity to eliminate infections, as well as the functions of interleukins. Explore how these signaling proteins interact in the immune system.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
