CV Risk Assessment: Atherosclerosis Overview

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Questions and Answers

What is the primary method used in Canada to identify patients for primary prevention of cardiovascular disease?

  • Polygenic risk score
  • Reynold’s risk score
  • Lipoprotein(a) levels
  • Framingham risk score (correct)

Which factor is measured by C reactive protein (CRP) as mentioned in the text?

  • Inflammation (correct)
  • Socioeconomic status
  • Psychosocial stress
  • Sedentarism

For individuals with systemic inflammation but normal cholesterol, what type of therapy has shown benefits in reducing cardiovascular events?

  • Psychosocial therapy
  • Socioeconomic therapy
  • Statins (correct)
  • Lipoprotein(a) therapy

What is the recommended action for patients identified with a Framingham risk score above 20% in Canada?

<p>High-risk preventive measures (A)</p> Signup and view all the answers

How is socioeconomic status typically measured in the context of assessing cardiovascular risk?

<p>By education and occupation (D)</p> Signup and view all the answers

What is the typical clinical manifestation of atherosclerosis in the renal circulatory territory?

<p>Ischemic nephropathy (D)</p> Signup and view all the answers

What shift in risk factor patterns has led to 80% of deaths due to cardiovascular disease now being in low and middle-income countries?

<p>Rise in traditional risk factors prevalence (A)</p> Signup and view all the answers

According to the Interheart Study, how many risk factors explain 90% of the risk for a first myocardial infarction?

<p>9 (C)</p> Signup and view all the answers

What is the typical clinical manifestation of atherosclerosis in the cerebral circulatory territory?

<p>Transient ischemic attack (C)</p> Signup and view all the answers

What was a limitation of the Framingham Heart Study in identifying risk factors for atherosclerotic disease?

<p>Inclusion of only Caucasion participants (A)</p> Signup and view all the answers

What issue might lead to seeing this page while browsing a secure website?

<p>Mistakenly bookmarking the web login form instead of the desired website (B)</p> Signup and view all the answers

Why might this page be presented instead of the desired website?

<p>As a security measure (D)</p> Signup and view all the answers

What is a potential consequence of not addressing the issue that causes this page to appear?

<p>Errors on certain browsers (A)</p> Signup and view all the answers

What potential issue could arise if this page is ignored and not addressed?

<p>Both a and b (D)</p> Signup and view all the answers

Why might a user see this page while browsing a secure website?

<p>Both a and b (A)</p> Signup and view all the answers

What is a key reason for misinterpreting maternal signs and symptoms during pregnancy?

<p>Growing pregnancy mass effect (C)</p> Signup and view all the answers

Why is knowledge of normal physiology in pregnancy important according to the text?

<p>To identify abnormal signs and symptoms (C)</p> Signup and view all the answers

Which group of Indigenous peoples is acknowledged for the land where the gathering takes place?

<p>Musqueam, Squamish, and Tsleil-Waututh (B)</p> Signup and view all the answers

What is emphasized by the mention of Dr. Christopher Ng being the Co-lead of Week 61?

<p>The involvement in a specific educational period (C)</p> Signup and view all the answers

Why might maternal signs and symptoms be mistakenly treated as pathology?

<p>Misinterpretation due to a growing pregnancy mass effect (C)</p> Signup and view all the answers

What is one of the objectives mentioned pertaining to pregnancy physiology?

<p>Defining gestational hypertension (D)</p> Signup and view all the answers

How are physiologic changes unique to pregnancy addressed according to the text?

<p>Using a systems-based approach (B)</p> Signup and view all the answers

Which organ system experiences anatomic and functional changes during pregnancy according to the text?

<p>Endocrine system (A)</p> Signup and view all the answers

'Why should you care?' according to the text refers to which concept?

<p>'Identifying abnormal signs and symptoms' (D)</p> Signup and view all the answers

What role do chylomicrons play in liver metabolism?

<p>Transport cholesterol out of the liver (A)</p> Signup and view all the answers

How does the liver handle triglycerides in metabolism?

<p>Metabolizes them for energy production (B)</p> Signup and view all the answers

What is the primary function of very low density lipoproteins (VLDL) in the liver?

<p>Export cholesterol to tissues (D)</p> Signup and view all the answers

How is ammonia detoxified in the liver?

<p>Converted to urea in the mitochondria (B)</p> Signup and view all the answers

What is the consequence of impaired excretion of bilirubin from the liver?

<p>Elevated levels of bilirubin in the bloodstream (D)</p> Signup and view all the answers

Why is conjugation of bilirubin important for liver function?

<p>To make bilirubin water soluble for excretion (A)</p> Signup and view all the answers

Which lipoprotein is responsible for exporting triglycerides and cholesterol from the liver to tissues?

<p>VLDL (B)</p> Signup and view all the answers

Where does the oxidation of fatty acids primarily occur for energy production?

<p>Liver (B)</p> Signup and view all the answers

How do high density lipoproteins (HDL) contribute to liver metabolism?

<p>Transport cholesterol to the liver (B)</p> Signup and view all the answers

What is the main function of bile salts derived from cholesterol?

<p>Digestion (D)</p> Signup and view all the answers

What is the main function of bile produced by the liver?

<p>Aid in emulsification and absorption of fats (C)</p> Signup and view all the answers

What is the primary method of excretion for bilirubin once it has been processed in the liver?

<p>Feces (A)</p> Signup and view all the answers

Which lipoprotein carries dietary triglycerides to tissues after being generated in the intestine?

<p>Chylomicrons (C)</p> Signup and view all the answers

What is the primary role of the liver in metabolizing ammonia and bilirubin?

<p>Converting ammonia to urea for excretion (B)</p> Signup and view all the answers

How does the liver contribute to the breakdown of triglycerides during metabolic processes?

<p>Production of ketone bodies (B)</p> Signup and view all the answers

What is the function of bile in relation to lipid digestion and absorption?

<p>Emulsifying fats to aid in digestion (A)</p> Signup and view all the answers

In what scenario would lactic acidosis most likely occur due to liver dysfunction?

<p>Reduced gluconeogenesis capacity (A)</p> Signup and view all the answers

Which metabolic function does the liver NOT directly perform?

<p>Hemoglobin synthesis (D)</p> Signup and view all the answers

What is a significant consequence of the liver's inability to metabolize bilirubin effectively?

<p>Jaundice due to bilirubin accumulation (A)</p> Signup and view all the answers

Which molecule is NOT synthesized by the liver as part of its plasma protein production?

<p>Immunoglobulins (C)</p> Signup and view all the answers

How does the liver contribute to maintaining normal blood glucose concentrations when glucose levels are low?

<p>Converts glycogen back to glucose through glycogenolysis (B)</p> Signup and view all the answers

What is the main function of bile salts in the body?

<p>Solubilize excreted lipids in bile and dietary lipids in the small intestines (D)</p> Signup and view all the answers

How does the small intestine contribute to the reabsorption of bile salts?

<p>By reabsorbing bile salts in the terminal ileum (C)</p> Signup and view all the answers

What role do glucuronic acid residues play in the metabolism of bilirubin?

<p>Converting bilirubin into urobilinogens (A)</p> Signup and view all the answers

Which of the following is a major function of bile produced by the liver?

<p>Digestion of fats (B)</p> Signup and view all the answers

How does the liver eliminate metabolic waste?

<p>As feces and urine (D)</p> Signup and view all the answers

What is the significance of bile canaliculi in the metabolism process?

<p>They receive bile from hepatocytes for drainage (B)</p> Signup and view all the answers

How are bile salts recycled in the body for further use?

<p>By recycling them back to the liver from the small intestine (D)</p> Signup and view all the answers

In what form does bilirubin get eliminated from the body?

<p>Converted into urobilinogens and excreted as feces and urine (A)</p> Signup and view all the answers

Which enzyme is liver-specific and serves as a marker of hepatocellular injury?

<p>ALT (D)</p> Signup and view all the answers

Which enzyme is found in many tissues but is primarily located in the liver, biliary tree, and bone?

<p>ALP (D)</p> Signup and view all the answers

Which enzyme confirms that elevated ALP levels are from the liver or biliary tree, and not from other sources like bone?

<p>GGT (A)</p> Signup and view all the answers

Which markers are indicators of cholestasis, signifying damage to the biliary tree?

<p>GGT and ALP (A)</p> Signup and view all the answers

Which liver function marker measures the liver's ability to produce proteins?

<p>Albumin (D)</p> Signup and view all the answers

In which condition can portal hypertension cause splenomegaly leading to low platelet count (thrombocytopenia)?

<p>Portal hypertension (A)</p> Signup and view all the answers

Which hormone plays a role in regulating enzyme expression and activity in the liver?

<p>Insulin (A)</p> Signup and view all the answers

In systemic catabolic states, what do hepatocytes release into the systemic circulation?

<p>Glucose (B)</p> Signup and view all the answers

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