Atherosclerosis

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Which step of the chronic inflammatory response involves the migration of lymphocytes into the intima?

Step Five

What is the consequence of atherosclerosis that occurs when the lipid core of a plaque is exposed?

Plaque rupture

What is the macroscopic appearance of a fatty streak?

Small yellow flat spots

What is the microscopic appearance of a stable plaque?

<p>Thickened fibrous caps with minimal lipid core</p> Signup and view all the answers

What is the consequence of plaque rupture in atherosclerosis?

<p>Formation of a blood clot</p> Signup and view all the answers

What is the consequence of an increase in lipid accumulation in atherosclerosis?

<p>Luminal narrowing</p> Signup and view all the answers

What is the consequence of luminal narrowing in atherosclerosis?

<p>Decrease in blood supply</p> Signup and view all the answers

What is the consequence of plaque rupture in atherosclerosis?

<p>Formation of a blood clot</p> Signup and view all the answers

What is the consequence of luminal obstruction in atherosclerosis?

<p>Infarction</p> Signup and view all the answers

What is the consequence of a blood clot formation in atherosclerosis?

<p>Luminal obstruction</p> Signup and view all the answers

Which of the following is the correct sequence of events in the development of atherosclerosis?

<p>Endothelial damage, monocyte migration, foam cell formation, fatty streak formation</p> Signup and view all the answers

What is the main cause of endothelial damage in atherosclerosis?

<p>LDL</p> Signup and view all the answers

What happens to monocytes in the development of atherosclerosis?

<p>They migrate through the endothelium</p> Signup and view all the answers

What are foam cells in the context of atherosclerosis?

<p>Macrophages or smooth muscle cells that engulf lipids</p> Signup and view all the answers

What is the earliest lesion of the atheroma called?

<p>Fatty streak</p> Signup and view all the answers

What is the main role of smooth muscle cells in the development of atherosclerosis?

<p>To provide structural support in the tunica media</p> Signup and view all the answers

What initiates the chronic inflammatory response in atherosclerosis?

<p>Endothelial damage</p> Signup and view all the answers

What causes the endothelium to become leaky in atherosclerosis?

<p>LDL oxidation</p> Signup and view all the answers

What is the role of monocytes in the development of atherosclerosis?

<p>To migrate through the endothelium</p> Signup and view all the answers

What is the main factor that attracts monocytes in the development of atherosclerosis?

<p>Inflammatory response</p> Signup and view all the answers

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