Creatine Kinase (CK) Function and Diagnostic Significance

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Questions and Answers

In which of the following tissues are CK levels the highest?

  • Skeletal muscle (correct)
  • Liver
  • Thyroid
  • Bladder

What is the main function of Creatine Kinase (CK)?

  • Assisting in ATP regeneration in muscle tissue (correct)
  • Aiding in digestion
  • Promoting bone growth
  • Regulating blood sugar levels

What is a diagnostic significance of elevated CK levels?

  • Anemia
  • High blood pressure
  • Muscular dystrophy (correct)
  • Respiratory infection

Which CK isoenzyme is a sensitive indicator of acute myocardial infarction (AMI)?

<p>CKMB (B)</p> Signup and view all the answers

What is the preferred marker for myocardial infarction?

<p>Troponin (D)</p> Signup and view all the answers

How is the measurement of CK isoenzymes typically carried out?

<p>Electrophoresis, ion-exchange chromatography, radioimmunoassay (RIA), and immunoinhibition methods (A)</p> Signup and view all the answers

Which method is 6 times faster for measuring Creatine Kinase (CK) levels?

<p>Oliver-Rosalki at pH 6.8 (B)</p> Signup and view all the answers

Which tissue has the smallest CK levels?

<p>Bladder (C)</p> Signup and view all the answers

What is the diagnostic significance of elevated CK BB levels?

<p>Tumor marker for prostatic carcinoma (D)</p> Signup and view all the answers

Which CK isoenzyme is a rare tumor marker due to its hindered passage across the blood-brain barrier?

<p>CKBB (A)</p> Signup and view all the answers

Which is the preferred marker for myocardial infarction?

<p>Troponin (C)</p> Signup and view all the answers

In which disorder are CK levels frequently elevated due to the high concentrations of CK in muscle tissue?

<p>Myocardial infarction (MI) (A)</p> Signup and view all the answers

Which method is NOT typically used for the measurement of CK isoenzymes?

<p>Polymerase chain reaction (PCR) (A)</p> Signup and view all the answers

Which tissue does NOT have high levels of CK?

<p>Pancreas (D)</p> Signup and view all the answers

What is the diagnostic significance of elevated CK BB levels?

<p>Tumor marker for prostatic carcinoma (B)</p> Signup and view all the answers

Which CK isoenzyme is associated with disorders of cardiac and skeletal muscle due to its high concentrations in muscle tissue?

<p>CKMM (C)</p> Signup and view all the answers

What is a sensitive indicator of acute myocardial infarction (AMI) and muscular dystrophy, specifically of Duchenne type?

<p>CKMM (A)</p> Signup and view all the answers

In which disorder are CK levels frequently elevated due to the high concentrations of CK in muscle tissue?

<p>All of the above (D)</p> Signup and view all the answers

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