COX Inhibitors and Their Effects
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Questions and Answers

What is a potential consequence of long-term intake of large doses of aspirin?

  • Decreased synthesis of clotting factors in the liver (correct)
  • Increased platelet aggregation
  • Increased synthesis of clotting factors in the liver
  • Increased bleeding time to nearly twice the normal value

    • What is a common side effect of aspirin on the gastrointestinal tract?

  • Increased absorption of nutrients
  • Irritation of gastric mucosa causing epigastric distress (correct)
  • Increased gastric mucosal protection
  • Reduced risk of gastrointestinal bleeding

    • How does aspirin affect platelet aggregation?

  • Decreases platelet aggregation (correct)
  • Increases platelet aggregation
  • Reversibly inhibits platelet aggregation
  • Has no effect on platelet aggregation

    • What percentage of plasma proteins is ibuprofen bound to?

    <p>90-99%</p> Signup and view all the answers

    What is the effect of aspirin on bleeding time?

    <p>Increases bleeding time to nearly twice the normal value</p> Signup and view all the answers

    What is the active metabolite of aspirin responsible for most of its actions?

    <p>Salicylic acid</p> Signup and view all the answers

    What is the rationale behind prophylactic vitamin K therapy in long-term aspirin intake?

    <p>To prevent bleeding complications</p> Signup and view all the answers

    What is the mechanism of aspirin's anti-inflammatory action?

    <p>Inhibition of thromboxane A2 synthesis</p> Signup and view all the answers

    Which of the following is a unique feature of nonselective COX inhibitors compared to selective COX-2 inhibitors?

    <p>Antiplatelet aggregatory effect</p> Signup and view all the answers

    What is a common adverse effect of NSAIDs on the gastrointestinal system?

    <p>Gastric mucosal damage and bleeding</p> Signup and view all the answers

    Which of the following is a potential consequence of NSAID use on the renal system?

    <p>Papillary necrosis</p> Signup and view all the answers

    What is the mechanism of action of COX inhibitors in reducing pain and inflammation?

    <p>Inhibition of prostaglandin synthesis</p> Signup and view all the answers

    Which of the following is a contraindication for NSAID use in pregnancy?

    <p>Risk of ductus arteriosus closure</p> Signup and view all the answers

    What is the effect of NSAIDs on antihypertensive medications?

    <p>Decreased antihypertensive effect</p> Signup and view all the answers

    Which of the following is a potential interaction between NSAIDs and diuretics?

    <p>Decreased diuretic effect</p> Signup and view all the answers

    What is the effect of NSAIDs on the central nervous system?

    <p>Headache and mental confusion</p> Signup and view all the answers

    Which of the following is an example of a preferential COX-2 inhibitor?

    <p>Nimesulide</p> Signup and view all the answers

    What is the primary mechanism of analgesic action of NSAIDs?

    <p>Inhibition of prostaglandin synthesis</p> Signup and view all the answers

    Which of the following NSAIDs has a poor anti-inflammatory action?

    <p>Paracetamol</p> Signup and view all the answers

    What is the major advantage of COX-2 selective inhibitors over non-selective COX inhibitors?

    <p>Reduced risk of gastric mucosal damage</p> Signup and view all the answers

    Which of the following is a potential renal toxicity associated with NSAID use?

    <p>All of the above</p> Signup and view all the answers

    Which of the following is NOT a characteristic of opioid-like analgesics?

    <p>Inhibit prostaglandin synthesis</p> Signup and view all the answers

    What is the primary mechanism of anti-inflammatory action of NSAIDs?

    <p>Inhibition of prostaglandin synthesis</p> Signup and view all the answers

    Which of the following is an enzyme inhibited by NSAIDs?

    <p>Cyclooxygenase</p> Signup and view all the answers

    What is the primary effect of COX-1 and COX-2 inhibitors on the metabolism of arachidonic acid?

    <p>Inhibition of cyclooxygenase</p> Signup and view all the answers

    What is a beneficial action of prostaglandins in the context of pain management?

    <p>Prevention of nerve ending sensitization</p> Signup and view all the answers

    What is the mechanism of anti-inflammatory action of COX inhibitors?

    <p>Inhibition of prostaglandin synthesis</p> Signup and view all the answers

    What is a potential gastric toxicity associated with long-term use of COX inhibitors?

    <p>Gastric mucosal damage</p> Signup and view all the answers

    What is a potential renal toxicity associated with long-term use of COX inhibitors?

    <p>Nephrotoxicity</p> Signup and view all the answers

    What is the effect of leukotriene B4 on human neutrophils?

    <p>Enhancement of chemotactic responses</p> Signup and view all the answers

    What is the role of prostacyclin in the context of platelet aggregation?

    <p>Inhibition of platelet aggregation</p> Signup and view all the answers

    What is the effect of leukotriene C4 on the vasculature?

    <p>Vasoconstriction</p> Signup and view all the answers

    What is the main factor limiting the absorption of aspirin in the stomach and small intestines?

    <p>Poor water solubility</p> Signup and view all the answers

    What is the combined plasma half-life of aspirin and salicylic acid?

    <p>3-5 hours</p> Signup and view all the answers

    What is a potential serious adverse effect of aspirin hypersensitivity?

    <p>Anaphylactoid reaction</p> Signup and view all the answers

    What is the term for the syndrome caused by high doses of aspirin?

    <p>Salicylism</p> Signup and view all the answers

    What is a potential long-term effect of high-dose aspirin therapy?

    <p>Insidious onset hepatic injury</p> Signup and view all the answers

    What is a common adverse effect of aspirin in children?

    <p>Reye's syndrome</p> Signup and view all the answers

    What is a symptom of salicylism?

    <p>Dizziness</p> Signup and view all the answers

    What is a potential complication of acute salicylate poisoning?

    <p>All of the above</p> Signup and view all the answers

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