COX Inhibitors and Their Effects

Play an AI-generated podcast conversation about this lesson

What is a potential consequence of long-term intake of large doses of aspirin?

Decreased synthesis of clotting factors in the liver (correct)
Increased platelet aggregation
Increased synthesis of clotting factors in the liver
Increased bleeding time to nearly twice the normal value

What is a common side effect of aspirin on the gastrointestinal tract?

Increased absorption of nutrients
Irritation of gastric mucosa causing epigastric distress (correct)
Increased gastric mucosal protection
Reduced risk of gastrointestinal bleeding

How does aspirin affect platelet aggregation?

Decreases platelet aggregation (correct)
Increases platelet aggregation
Reversibly inhibits platelet aggregation
Has no effect on platelet aggregation

What percentage of plasma proteins is ibuprofen bound to?

90-99% (D) Signup and view all the answers

What is the effect of aspirin on bleeding time?

Increases bleeding time to nearly twice the normal value (D) Signup and view all the answers

What is the active metabolite of aspirin responsible for most of its actions?

Salicylic acid (B) Signup and view all the answers

What is the rationale behind prophylactic vitamin K therapy in long-term aspirin intake?

To prevent bleeding complications (D) Signup and view all the answers

What is the mechanism of aspirin's anti-inflammatory action?

Inhibition of thromboxane A2 synthesis (B) Signup and view all the answers

Which of the following is a unique feature of nonselective COX inhibitors compared to selective COX-2 inhibitors?

Antiplatelet aggregatory effect (B) Signup and view all the answers

What is a common adverse effect of NSAIDs on the gastrointestinal system?

Gastric mucosal damage and bleeding (B) Signup and view all the answers

Which of the following is a potential consequence of NSAID use on the renal system?

Papillary necrosis (A) Signup and view all the answers

What is the mechanism of action of COX inhibitors in reducing pain and inflammation?

Inhibition of prostaglandin synthesis (A) Signup and view all the answers

Which of the following is a contraindication for NSAID use in pregnancy?

Risk of ductus arteriosus closure (B) Signup and view all the answers

What is the effect of NSAIDs on antihypertensive medications?

Decreased antihypertensive effect (B) Signup and view all the answers

Which of the following is a potential interaction between NSAIDs and diuretics?

Decreased diuretic effect (B) Signup and view all the answers

What is the effect of NSAIDs on the central nervous system?

Headache and mental confusion (B) Signup and view all the answers

Which of the following is an example of a preferential COX-2 inhibitor?

Nimesulide (A) Signup and view all the answers

What is the primary mechanism of analgesic action of NSAIDs?

Inhibition of prostaglandin synthesis (B) Signup and view all the answers

Which of the following NSAIDs has a poor anti-inflammatory action?

Paracetamol (B) Signup and view all the answers

What is the major advantage of COX-2 selective inhibitors over non-selective COX inhibitors?

Reduced risk of gastric mucosal damage (A) Signup and view all the answers

Which of the following is a potential renal toxicity associated with NSAID use?

All of the above (D) Signup and view all the answers

Which of the following is NOT a characteristic of opioid-like analgesics?

Inhibit prostaglandin synthesis (D) Signup and view all the answers

What is the primary mechanism of anti-inflammatory action of NSAIDs?

Inhibition of prostaglandin synthesis (C) Signup and view all the answers

Which of the following is an enzyme inhibited by NSAIDs?

Cyclooxygenase (A) Signup and view all the answers

What is the primary effect of COX-1 and COX-2 inhibitors on the metabolism of arachidonic acid?

Inhibition of cyclooxygenase (B) Signup and view all the answers

What is a beneficial action of prostaglandins in the context of pain management?

Prevention of nerve ending sensitization (C) Signup and view all the answers

What is the mechanism of anti-inflammatory action of COX inhibitors?

Inhibition of prostaglandin synthesis (B) Signup and view all the answers

What is a potential gastric toxicity associated with long-term use of COX inhibitors?

Gastric mucosal damage (C) Signup and view all the answers

What is a potential renal toxicity associated with long-term use of COX inhibitors?

Nephrotoxicity (C) Signup and view all the answers

What is the effect of leukotriene B4 on human neutrophils?

Enhancement of chemotactic responses (A) Signup and view all the answers

What is the role of prostacyclin in the context of platelet aggregation?

Inhibition of platelet aggregation (A) Signup and view all the answers

What is the effect of leukotriene C4 on the vasculature?

Vasoconstriction (D) Signup and view all the answers

What is the main factor limiting the absorption of aspirin in the stomach and small intestines?

Poor water solubility (C) Signup and view all the answers

What is the combined plasma half-life of aspirin and salicylic acid?

3-5 hours (C) Signup and view all the answers

What is a potential serious adverse effect of aspirin hypersensitivity?

Anaphylactoid reaction (B) Signup and view all the answers

What is the term for the syndrome caused by high doses of aspirin?

Salicylism (B) Signup and view all the answers

What is a potential long-term effect of high-dose aspirin therapy?

Insidious onset hepatic injury (C) Signup and view all the answers

What is a common adverse effect of aspirin in children?

Reye's syndrome (B) Signup and view all the answers

What is a symptom of salicylism?

Dizziness (D) Signup and view all the answers

What is a potential complication of acute salicylate poisoning?