40 Questions
What is a potential consequence of long-term intake of large doses of aspirin?
Decreased synthesis of clotting factors in the liver
What is a common side effect of aspirin on the gastrointestinal tract?
Irritation of gastric mucosa causing epigastric distress
How does aspirin affect platelet aggregation?
Decreases platelet aggregation
What percentage of plasma proteins is ibuprofen bound to?
90-99%
What is the effect of aspirin on bleeding time?
Increases bleeding time to nearly twice the normal value
What is the active metabolite of aspirin responsible for most of its actions?
Salicylic acid
What is the rationale behind prophylactic vitamin K therapy in long-term aspirin intake?
To prevent bleeding complications
What is the mechanism of aspirin's anti-inflammatory action?
Inhibition of thromboxane A2 synthesis
Which of the following is a unique feature of nonselective COX inhibitors compared to selective COX-2 inhibitors?
Antiplatelet aggregatory effect
What is a common adverse effect of NSAIDs on the gastrointestinal system?
Gastric mucosal damage and bleeding
Which of the following is a potential consequence of NSAID use on the renal system?
Papillary necrosis
What is the mechanism of action of COX inhibitors in reducing pain and inflammation?
Inhibition of prostaglandin synthesis
Which of the following is a contraindication for NSAID use in pregnancy?
Risk of ductus arteriosus closure
What is the effect of NSAIDs on antihypertensive medications?
Decreased antihypertensive effect
Which of the following is a potential interaction between NSAIDs and diuretics?
Decreased diuretic effect
What is the effect of NSAIDs on the central nervous system?
Headache and mental confusion
Which of the following is an example of a preferential COX-2 inhibitor?
Nimesulide
What is the primary mechanism of analgesic action of NSAIDs?
Inhibition of prostaglandin synthesis
Which of the following NSAIDs has a poor anti-inflammatory action?
Paracetamol
What is the major advantage of COX-2 selective inhibitors over non-selective COX inhibitors?
Reduced risk of gastric mucosal damage
Which of the following is a potential renal toxicity associated with NSAID use?
All of the above
Which of the following is NOT a characteristic of opioid-like analgesics?
Inhibit prostaglandin synthesis
What is the primary mechanism of anti-inflammatory action of NSAIDs?
Inhibition of prostaglandin synthesis
Which of the following is an enzyme inhibited by NSAIDs?
Cyclooxygenase
What is the primary effect of COX-1 and COX-2 inhibitors on the metabolism of arachidonic acid?
Inhibition of cyclooxygenase
What is a beneficial action of prostaglandins in the context of pain management?
Prevention of nerve ending sensitization
What is the mechanism of anti-inflammatory action of COX inhibitors?
Inhibition of prostaglandin synthesis
What is a potential gastric toxicity associated with long-term use of COX inhibitors?
Gastric mucosal damage
What is a potential renal toxicity associated with long-term use of COX inhibitors?
Nephrotoxicity
What is the effect of leukotriene B4 on human neutrophils?
Enhancement of chemotactic responses
What is the role of prostacyclin in the context of platelet aggregation?
Inhibition of platelet aggregation
What is the effect of leukotriene C4 on the vasculature?
Vasoconstriction
What is the main factor limiting the absorption of aspirin in the stomach and small intestines?
Poor water solubility
What is the combined plasma half-life of aspirin and salicylic acid?
3-5 hours
What is a potential serious adverse effect of aspirin hypersensitivity?
Anaphylactoid reaction
What is the term for the syndrome caused by high doses of aspirin?
Salicylism
What is a potential long-term effect of high-dose aspirin therapy?
Insidious onset hepatic injury
What is a common adverse effect of aspirin in children?
Reye's syndrome
What is a symptom of salicylism?
Dizziness
What is a potential complication of acute salicylate poisoning?
All of the above
This quiz covers the effects of nonselective COX inhibitors and selective COX-2 inhibitors on various physiological processes, including pain, fever, inflammation, and platelet function.
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